VKORC1 and MT1X

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		VKORC1	MT1X
Gene Name		vitamin K epoxide reductase complex, subunit 1	metallothionein 1X
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleus Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding	Zinc Ion Binding Metal Ion Binding
	Biological Process	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development	Cellular Zinc Ion Homeostasis Nitric Oxide Mediated Signal Transduction Response To Metal Ion Detoxification Of Copper Ion Cellular Response To Erythropoietin Negative Regulation Of Growth Cellular Response To Cadmium Ion Cellular Response To Zinc Ion
Pathways		Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Warfarin maintenance dose ( 18535201 20833655 19300499)	Gambling ( 22780124)
Protein-Protein Interactions		80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB	4 interactors: POT1 TERF1 TERF2IP VKORC1
Entrez ID		79001	4501
HPRD ID		10540	01130
Ensembl ID		ENSG00000167397	ENSG00000187193
Uniprot IDs		Q9BQB6	P80297
PDB IDs
Enriched GO Terms of Interacting Partners?		Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport	Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of Chromosome Organization Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Negative Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Chromosome Organization Negative Regulation Of DNA Biosynthetic Process DNA Replication Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Recombination At Telomere Regulation Of DNA Replication Regulation Of Organelle Organization Chromosome Organization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication DNA Metabolic Process Telomeric Loop Formation Telomere Formation Via Telomerase Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Homeostatic Process Protection From Non-homologous End Joining At Telomere Positive Regulation Of Helicase Activity Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Transferase Activity Positive Regulation Of Telomerase Activity Vitamin K Metabolic Process Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Organelle Organization Positive Regulation Of Telomere Maintenance Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Polymerization Regulation Of Double-strand Break Repair Via Homologous Recombination Peptidyl-glutamic Acid Carboxylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Recombination Regulation Of Double-strand Break Repair
Tagcloud ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	annotation cbs degs description devastating diffuse downloaded etiology foundation fpr1 gse idiopathic iips il1r2 interstitial kinds mgam parenchymal played pneumonias ppi profiling s100a12 screened sdr16c5 serpina3 slco4a1 subtypes underscores
Tagcloud (Difference) ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	annotation cbs degs description devastating diffuse downloaded etiology foundation fpr1 gse idiopathic iips il1r2 interstitial kinds mgam parenchymal played pneumonias ppi profiling s100a12 screened sdr16c5 serpina3 slco4a1 subtypes underscores
Tagcloud (Intersection) ?