APBA1 and HTR2C

Number of citations of the paper that reports this interaction (PMID 12006486)
23

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		APBA1	HTR2C
Gene Name		amyloid beta (A4) precursor protein-binding, family A, member 1	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Golgi Apparatus Plasma Membrane Synaptic Vesicle Protein Complex Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Beta-amyloid Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding PDZ Domain Binding Protein Complex Binding	Gq/11-coupled Serotonin Receptor Activity Serotonin Receptor Activity Drug Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
	Biological Process	In Utero Embryonic Development Protein Complex Assembly Intracellular Protein Transport Cell Adhesion Synaptic Transmission Nervous System Development Locomotory Behavior Axon Cargo Transport Regulation Of Gene Expression Glutamate Secretion Gamma-aminobutyric Acid Secretion Multicellular Organism Growth	Behavioral Fear Response CGMP Biosynthetic Process Cellular Calcium Ion Homeostasis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Neurological System Process Regulation Of Appetite Response To Drug Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs			Tramadol Ziprasidone Methysergide Cabergoline Ropinirole Olanzapine Clozapine Mirtazapine Loxapine Pramipexole Promazine Cyproheptadine Fenfluramine Lisuride Trazodone Apomorphine Risperidone Propiomazine Minaprine Tegaserod Doxepin Nefazodone Pergolide Dexfenfluramine Bromocriptine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine 3,4-Methylenedioxymethamphetamine Lorcaserin Sertindole Mianserin Asenapine Agomelatine
Diseases
GWAS
Protein-Protein Interactions		15 interactors: APP CACNA1B CASK CCS CNTNAP3 CNTNAP4 HTR2C KCNJ12 KIF17 LIN7B NOTCH1 NRXN1 PSEN1 STX1A STXBP1	8 interactors: APBA1 ARRB2 CALM1 DLG4 GNAQ LIN7C MPDZ SNTA1
Entrez ID		320	3358
HPRD ID		03879	02429
Ensembl ID		ENSG00000107282	ENSG00000147246
Uniprot IDs		Q02410	K9J958 P28335
PDB IDs		1AQC 1U37 1U38 1U39 1U3B 1X11 1X45 1Y7N
Enriched GO Terms of Interacting Partners?		Secretion Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Secretion By Cell Neurotransmitter Transport Cell-cell Signaling Synaptic Transmission Establishment Of Localization In Cell Transport Cellular Localization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Synaptic Transmission Exocytosis Cell Adhesion Ion Transport Regulation Of Grooming Behavior Metal Ion Transport Vesicle Localization Regulation Of Peptide Hormone Secretion Regulation Of Synaptic Vesicle Priming Establishment Of Protein Localization Dicarboxylic Acid Transport Regulation Of Hormone Secretion Regulation Of Membrane Potential Behavior Regulation Of Secretion Synaptic Vesicle Transport Cation Transport Regulation Of Receptor Activity Membrane Depolarization Notch Receptor Processing Extracellular Matrix Organization Extracellular Structure Organization Protein Localization Notch Signaling Pathway Glutamate Secretion Organelle Localization Regulation Of Ion Transmembrane Transport Regulation Of Exocytosis Amino Acid Transport Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Single-organism Behavior Vesicle-mediated Transport Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Behavior Calcium Ion Import Regulation Of Synaptic Vesicle Exocytosis Regulation Of Signaling	Maintenance Of Apical/basal Cell Polarity Maintenance Of Cell Polarity Secretion By Cell Nervous System Development Behavior Platelet Activation Regulation Of Ion Transport Secretion Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Receptor Internalization Locomotory Behavior Regulation Of Membrane Potential Negative Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Negative Regulation Of Protein Metabolic Process Activation Of Phospholipase C Activity Cell-cell Signaling Exocytosis Positive Regulation Of Phospholipase C Activity Developmental Process Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Phospholipase Activity Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Phospholipase Activity Regulation Of Striated Muscle Contraction Action Potential Positive Regulation Of Lipase Activity Positive Regulation Of Calcium Ion Transport Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Synaptic Transmission System Development Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Body Fluid Levels Synaptic Transmission Vesicle-mediated Transport Wound Healing Establishment Of Protein Localization Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Activation Regulation Of Muscle Contraction Multicellular Organismal Development Response To Wounding Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Tagcloud ?		abpa1 cask compromised consisting cortical distinctly dysregulated glutamate hypofunction involve kif17 layer mediating microtubule mlin7 mlin7a mlin7c neurotransmission nmda nr2a nr2b overlapped pathophysiology postmortem prominent schizophrenia separate trafficking transcripts	accessible becoming bioinformatics c10orf26 cacna1c circuitry csmd1 ephrin erbb4 freely gabra1 grin2a grm5 gsk3b guidance ingenuity ipa nrg2 ns polygenic schizophrenia searches silence szgr targetscan tcf4 thousands top znf804a
Tagcloud (Difference) ?		abpa1 cask compromised consisting cortical distinctly dysregulated glutamate hypofunction involve kif17 layer mediating microtubule mlin7 mlin7a mlin7c neurotransmission nmda nr2a nr2b overlapped pathophysiology postmortem prominent separate trafficking transcripts	accessible becoming bioinformatics c10orf26 cacna1c circuitry csmd1 ephrin erbb4 freely gabra1 grin2a grm5 gsk3b guidance ingenuity ipa nrg2 ns polygenic searches silence szgr targetscan tcf4 thousands top znf804a
Tagcloud (Intersection) ?		schizophrenia