APBA1 and CASK

Number of citations of the paper that reports this interaction (PMID 9753324)
92

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)
HPRD (in vivo, in vitro)

		APBA1	CASK
Gene Name		amyloid beta (A4) precursor protein-binding, family A, member 1	calcium/calmodulin-dependent serine protein kinase (MAGUK family)
Image
Gene Ontology Annotations	Cellular Component	Nucleus Golgi Apparatus Plasma Membrane Synaptic Vesicle Protein Complex Perinuclear Region Of Cytoplasm	Basement Membrane Nuclear Lamina Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Actin Cytoskeleton Basolateral Plasma Membrane Nuclear Matrix Presynaptic Membrane Ciliary Membrane
	Molecular Function	Beta-amyloid Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding PDZ Domain Binding Protein Complex Binding	Guanylate Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Neurexin Family Protein Binding
	Biological Process	In Utero Embryonic Development Protein Complex Assembly Intracellular Protein Transport Cell Adhesion Synaptic Transmission Nervous System Development Locomotory Behavior Axon Cargo Transport Regulation Of Gene Expression Glutamate Secretion Gamma-aminobutyric Acid Secretion Multicellular Organism Growth	Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Cell Adhesion Negative Regulation Of Keratinocyte Proliferation Extracellular Matrix Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleotide Phosphorylation Negative Regulation Of Wound Healing Calcium Ion Import Positive Regulation Of Calcium Ion Import Negative Regulation Of Cellular Response To Growth Factor Stimulus
Pathways			Syndecan interactions Nephrin interactions Non-integrin membrane-ECM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: APP CACNA1B CASK CCS CNTNAP3 CNTNAP4 HTR2C KCNJ12 KIF17 LIN7B NOTCH1 NRXN1 PSEN1 STX1A STXBP1	60 interactors: APBA1 ATP2B4 BNIP3L C16orf70 CADM1 CASKIN1 CDK9 CNTNAP2 CNTNAP4 DFNB31 DLG1 DLG4 DUSP3 ELL2 EPB41 EPS8 ERBB2IP F11R FCHSD2 GCNT3 GLS2 GRIK2 GRIN2A HGS ID1 IL15RA IL18 KCNA4 KCNJ12 KCNJ2 KCNJ4 LIN7A LIN7B MARS MLLT6 NPHS1 NRXN1 NRXN2 NRXN3 P2RX7 PARK2 PCBP2 PCM1 PLK2 PRKD2 PTGS2 RAB3A RPH3A SDC1 SDC2 SDC3 SDC4 SH2D4A SMEK1 SRPK2 TANC1 TBR1 TRIM22 TSPYL2 WNT7B
Entrez ID		320	8573
HPRD ID		03879	02164
Ensembl ID		ENSG00000107282	ENSG00000147044
Uniprot IDs		Q02410	O14936
PDB IDs		1AQC 1U37 1U38 1U39 1U3B 1X11 1X45 1Y7N	1KGD 1KWA 1ZL8 3C0G 3C0H 3C0I 3MFR 3MFS 3MFT 3MFU 3TAC
Enriched GO Terms of Interacting Partners?		Secretion Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Secretion By Cell Neurotransmitter Transport Cell-cell Signaling Synaptic Transmission Establishment Of Localization In Cell Transport Cellular Localization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Synaptic Transmission Exocytosis Cell Adhesion Ion Transport Regulation Of Grooming Behavior Metal Ion Transport Vesicle Localization Regulation Of Peptide Hormone Secretion Regulation Of Synaptic Vesicle Priming Establishment Of Protein Localization Dicarboxylic Acid Transport Regulation Of Hormone Secretion Regulation Of Membrane Potential Behavior Regulation Of Secretion Synaptic Vesicle Transport Cation Transport Regulation Of Receptor Activity Membrane Depolarization Notch Receptor Processing Extracellular Matrix Organization Extracellular Structure Organization Protein Localization Notch Signaling Pathway Glutamate Secretion Organelle Localization Regulation Of Ion Transmembrane Transport Regulation Of Exocytosis Amino Acid Transport Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Single-organism Behavior Vesicle-mediated Transport Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Behavior Calcium Ion Import Regulation Of Synaptic Vesicle Exocytosis Regulation Of Signaling	Synaptic Transmission Signaling Cell Communication Cell-cell Signaling Regulation Of Neurotransmitter Levels Learning Vocalization Behavior Neurotransmitter Secretion Neurotransmitter Transport Single-organism Behavior Learning Or Memory Behavior Cognition Establishment Or Maintenance Of Apical/basal Cell Polarity Cellular Protein Localization Cellular Localization Response To External Stimulus Anatomical Structure Development Social Behavior Cellular Component Assembly Regulation Of Synaptic Transmission System Development Regulation Of Cellular Component Organization Response To Stimulus Synapse Organization Regulation Of Grooming Behavior Regulation Of Organelle Organization Protein Localization To Membrane Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Response To Abiotic Stimulus Multicellular Organismal Development Regulation Of Ion Transport Protein Localization Secretion By Cell Membrane Depolarization Developmental Process Anatomical Structure Morphogenesis Neurological System Process Maintenance Of Apical/basal Cell Polarity Cell Adhesion Membrane Organization Receptor Localization To Synapse Regulation Of Cellular Localization Synapse Assembly Regulation Of Signaling Positive Regulation Of Transport Angiogenesis Regulation Of Intracellular Signal Transduction Secretion Positive Regulation Of Exosomal Secretion
Tagcloud ?		abpa1 cask compromised consisting cortical distinctly dysregulated glutamate hypofunction involve kif17 layer mediating microtubule mlin7 mlin7a mlin7c neurotransmission nmda nr2a nr2b overlapped pathophysiology postmortem prominent schizophrenia separate trafficking transcripts	channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gk gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo
Tagcloud (Difference) ?		abpa1 compromised consisting cortical distinctly dysregulated glutamate hypofunction involve kif17 layer mediating microtubule mlin7 mlin7a mlin7c neurotransmission nmda nr2a nr2b overlapped pathophysiology postmortem prominent schizophrenia separate trafficking transcripts	channels clustering coclusters coimmunoprecipitates colocalizes constituent cooh enzymatic fact gk gkap guanylate heterologous homology isolation junction lin maguk nh2 obscure organization pdz postsynaptic psd sap90 sh3 synaptic termed zo
Tagcloud (Intersection) ?		cask