APBA1 and CCS

Number of citations of the paper that reports this interaction (PMID 11115513)
7

Data Source:
HPRD (in vitro, in vivo)

		APBA1	CCS
Gene Name		amyloid beta (A4) precursor protein-binding, family A, member 1	copper chaperone for superoxide dismutase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Golgi Apparatus Plasma Membrane Synaptic Vesicle Protein Complex Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	Beta-amyloid Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding PDZ Domain Binding Protein Complex Binding	Superoxide Dismutase Activity Copper Ion Transmembrane Transporter Activity Copper Ion Binding Protein Binding Zinc Ion Binding Protein Disulfide Oxidoreductase Activity
	Biological Process	In Utero Embryonic Development Protein Complex Assembly Intracellular Protein Transport Cell Adhesion Synaptic Transmission Nervous System Development Locomotory Behavior Axon Cargo Transport Regulation Of Gene Expression Glutamate Secretion Gamma-aminobutyric Acid Secretion Multicellular Organism Growth	Response To Reactive Oxygen Species Superoxide Metabolic Process Intracellular Copper Ion Transport Removal Of Superoxide Radicals Copper Ion Transmembrane Transport Positive Regulation Of Oxidoreductase Activity Oxidation-reduction Process
Pathways			Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		15 interactors: APP CACNA1B CASK CCS CNTNAP3 CNTNAP4 HTR2C KCNJ12 KIF17 LIN7B NOTCH1 NRXN1 PSEN1 STX1A STXBP1	3 interactors: APBA1 SOD1 YWHAG
Entrez ID		320	9973
HPRD ID		03879	04841
Ensembl ID		ENSG00000107282	ENSG00000173992
Uniprot IDs		Q02410	O14618
PDB IDs		1AQC 1U37 1U38 1U39 1U3B 1X11 1X45 1Y7N	1DO5 2CRL 2RSQ
Enriched GO Terms of Interacting Partners?		Secretion Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Secretion By Cell Neurotransmitter Transport Cell-cell Signaling Synaptic Transmission Establishment Of Localization In Cell Transport Cellular Localization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Synaptic Transmission Exocytosis Cell Adhesion Ion Transport Regulation Of Grooming Behavior Metal Ion Transport Vesicle Localization Regulation Of Peptide Hormone Secretion Regulation Of Synaptic Vesicle Priming Establishment Of Protein Localization Dicarboxylic Acid Transport Regulation Of Hormone Secretion Regulation Of Membrane Potential Behavior Regulation Of Secretion Synaptic Vesicle Transport Cation Transport Regulation Of Receptor Activity Membrane Depolarization Notch Receptor Processing Extracellular Matrix Organization Extracellular Structure Organization Protein Localization Notch Signaling Pathway Glutamate Secretion Organelle Localization Regulation Of Ion Transmembrane Transport Regulation Of Exocytosis Amino Acid Transport Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Single-organism Behavior Vesicle-mediated Transport Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Behavior Calcium Ion Import Regulation Of Synaptic Vesicle Exocytosis Regulation Of Signaling	Axon Cargo Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Response To Antipsychotic Drug Positive Regulation Of Apoptotic Signaling Pathway Intracellular Transport Locomotory Behavior Negative Regulation Of Cholesterol Biosynthetic Process Gamma-aminobutyric Acid Secretion Response To Carbon Monoxide Microtubule-based Movement Establishment Of Localization In Cell Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Response To Potassium Ion Positive Regulation Of Oxidative Stress-induced Cell Death Nervous System Development Cellular Localization Positive Regulation Of Superoxide Anion Generation Cellular Response To ATP Relaxation Of Vascular Smooth Muscle Auditory Receptor Cell Stereocilium Organization Response To Potassium Ion Gamma-aminobutyric Acid Transport Cellular Response To Organonitrogen Compound Hydrogen Peroxide Biosynthetic Process Relaxation Of Smooth Muscle Retrograde Axon Cargo Transport Secretion By Cell Auditory Receptor Cell Morphogenesis Regulation Of Superoxide Anion Generation Neurofilament Cytoskeleton Organization Positive Regulation Of Apoptotic Process Negative Regulation Of Smooth Muscle Contraction Behavior Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Secretion Superoxide Anion Generation Auditory Receptor Cell Development Cellular Response To Cadmium Ion Inner Ear Receptor Stereocilium Organization Removal Of Superoxide Radicals Regulation Of Cholesterol Biosynthetic Process Cellular Response To Superoxide Negative Regulation Of Muscle Contraction Relaxation Of Muscle Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Protein Kinase Activity Response To Copper Ion Negative Regulation Of Steroid Biosynthetic Process
Tagcloud ?		abpa1 cask compromised consisting cortical distinctly dysregulated glutamate hypofunction involve kif17 layer mediating microtubule mlin7 mlin7a mlin7c neurotransmission nmda nr2a nr2b overlapped pathophysiology postmortem prominent schizophrenia separate trafficking transcripts	angina angiographic atherosclerosis braunwald clauss consecutively coronary correlate count degree fibrinogen hundred hyperfibrinogenemia irregularities leucocyte leucocytosis luminal offer pectoris rest sclerosis sixteen stenosis subgroup tendency thrombogenesis unstable vd vessel
Tagcloud (Difference) ?		abpa1 cask compromised consisting cortical distinctly dysregulated glutamate hypofunction involve kif17 layer mediating microtubule mlin7 mlin7a mlin7c neurotransmission nmda nr2a nr2b overlapped pathophysiology postmortem prominent schizophrenia separate trafficking transcripts	angina angiographic atherosclerosis braunwald clauss consecutively coronary correlate count degree fibrinogen hundred hyperfibrinogenemia irregularities leucocyte leucocytosis luminal offer pectoris rest sclerosis sixteen stenosis subgroup tendency thrombogenesis unstable vd vessel
Tagcloud (Intersection) ?