HTR2C and MPDZ

Number of citations of the paper that reports this interaction (PMID 11150294)
30

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		HTR2C	MPDZ
Gene Name		5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	multiple PDZ domain protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Tight Junction Postsynaptic Density Apical Plasma Membrane Apicolateral Plasma Membrane Dendrite Cytoplasmic Vesicle Schmidt-Lanterman Incisure Postsynaptic Membrane
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity Serotonin Receptor Activity Drug Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding	Protein Binding Protein C-terminus Binding
	Biological Process	Behavioral Fear Response CGMP Biosynthetic Process Cellular Calcium Ion Homeostasis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Neurological System Process Regulation Of Appetite Response To Drug Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade	Cell Adhesion Viral Process Myelination
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors
Drugs		Tramadol Ziprasidone Methysergide Cabergoline Ropinirole Olanzapine Clozapine Mirtazapine Loxapine Pramipexole Promazine Cyproheptadine Fenfluramine Lisuride Trazodone Apomorphine Risperidone Propiomazine Minaprine Tegaserod Doxepin Nefazodone Pergolide Dexfenfluramine Bromocriptine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine 3,4-Methylenedioxymethamphetamine Lorcaserin Sertindole Mianserin Asenapine Agomelatine
Diseases
GWAS			Corneal structure ( 23291589)
Protein-Protein Interactions		8 interactors: APBA1 ARRB2 CALM1 DLG4 GNAQ LIN7C MPDZ SNTA1	13 interactors: ABCA1 CAMK2A CLDN1 CLDN5 CSPG4 DRD3 F11R HTR2C KIT PLEKHA1 PLEKHA2 RNF5 SYNGAP1
Entrez ID		3358	8777
HPRD ID		02429	09155
Ensembl ID		ENSG00000147246	ENSG00000107186
Uniprot IDs		K9J958 P28335	F5H1U9 O75970
PDB IDs			2FCF 2FNE 2IWN 2IWO 2IWP 2IWQ 2O2T 2OPG 2QG1
Enriched GO Terms of Interacting Partners?		Maintenance Of Apical/basal Cell Polarity Maintenance Of Cell Polarity Secretion By Cell Nervous System Development Behavior Platelet Activation Regulation Of Ion Transport Secretion Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Receptor Internalization Locomotory Behavior Regulation Of Membrane Potential Negative Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Negative Regulation Of Protein Metabolic Process Activation Of Phospholipase C Activity Cell-cell Signaling Exocytosis Positive Regulation Of Phospholipase C Activity Developmental Process Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Phospholipase Activity Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Phospholipase Activity Regulation Of Striated Muscle Contraction Action Potential Positive Regulation Of Lipase Activity Positive Regulation Of Calcium Ion Transport Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Synaptic Transmission System Development Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Body Fluid Levels Synaptic Transmission Vesicle-mediated Transport Wound Healing Establishment Of Protein Localization Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Activation Regulation Of Muscle Contraction Multicellular Organismal Development Response To Wounding Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity	Regulation Of Intracellular Signal Transduction Regulation Of Neuronal Synaptic Plasticity Regulation Of Signaling Visual Learning Visual Behavior Associative Learning Regulation Of Synaptic Transmission Regulation Of Signal Transduction Learning Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Response To Radiation Single-organism Behavior Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Membrane Permeability Response To Abiotic Stimulus Negative Regulation Of Protein Kinase B Signaling Behavior Regulation Of MAPK Cascade Cellular Response To Stimulus Signal Transduction Learning Or Memory Cognition Negative Regulation Of Cell Differentiation Regulation Of Lipid Metabolic Process Homeostatic Process Rhythmic Process Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Mast Cell Proliferation Signaling Response To Light Stimulus Cell Communication Membrane Organization Chemical Homeostasis Positive Regulation Of Metabolic Process Cellular Localization Response To Stress Regulation Of Cell Differentiation Regulation Of CAMP Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Sodium:proton Antiporter Activity Regulation Of Corticotropin-releasing Hormone Secretion Gastric Emptying Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway
Tagcloud ?		accessible becoming bioinformatics c10orf26 cacna1c circuitry csmd1 ephrin erbb4 freely gabra1 grin2a grm5 gsk3b guidance ingenuity ipa nrg2 ns polygenic schizophrenia searches silence szgr targetscan tcf4 thousands top znf804a	a4 ace2 affective affectivity bonferroni combine converting correction endoperoxide exceeded gated nociceptive nonspecific oppera orofacial phenotypes prostaglandin ptgs1 rs10809907 rs1514280 rs3842803 rs466448 rs6432860 scn1a summation temporomandibular thresholds tmd
Tagcloud (Difference) ?		accessible becoming bioinformatics c10orf26 cacna1c circuitry csmd1 ephrin erbb4 freely gabra1 grin2a grm5 gsk3b guidance ingenuity ipa nrg2 ns polygenic schizophrenia searches silence szgr targetscan tcf4 thousands top znf804a	a4 ace2 affective affectivity bonferroni combine converting correction endoperoxide exceeded gated nociceptive nonspecific oppera orofacial phenotypes prostaglandin ptgs1 rs10809907 rs1514280 rs3842803 rs466448 rs6432860 scn1a summation temporomandibular thresholds tmd
Tagcloud (Intersection) ?