APBA1 and KIF17

Number of citations of the paper that reports this interaction (PMID 12514209)
42

Data Source:
HPRD (in vivo)

		APBA1	KIF17
Gene Name		amyloid beta (A4) precursor protein-binding, family A, member 1	kinesin family member 17
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Golgi Apparatus Plasma Membrane Synaptic Vesicle Protein Complex Perinuclear Region Of Cytoplasm	Cytosol Kinesin Complex Microtubule Axoneme Intraciliary Transport Particle B Photoreceptor Connecting Cilium Ciliary Basal Body Primary Cilium Periciliary Membrane Compartment
	Molecular Function	Beta-amyloid Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding PDZ Domain Binding Protein Complex Binding	ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity
	Biological Process	In Utero Embryonic Development Protein Complex Assembly Intracellular Protein Transport Cell Adhesion Synaptic Transmission Nervous System Development Locomotory Behavior Axon Cargo Transport Regulation Of Gene Expression Glutamate Secretion Gamma-aminobutyric Acid Secretion Multicellular Organism Growth	Organelle Organization Microtubule-based Movement Metabolic Process Protein Transport Vesicle-mediated Transport Neurogenesis Cell Projection Organization Protein Complex Localization
Pathways			Organelle biogenesis and maintenance Assembly of the primary cilium Intraflagellar transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: APP CACNA1B CASK CCS CNTNAP3 CNTNAP4 HTR2C KCNJ12 KIF17 LIN7B NOTCH1 NRXN1 PSEN1 STX1A STXBP1	7 interactors: APBA1 C16orf70 FHL5 GFI1B MAP3K10 MAP3K11 XPO1
Entrez ID		320	57576
HPRD ID		03879	10388
Ensembl ID		ENSG00000107282	ENSG00000117245
Uniprot IDs		Q02410	Q9P2E2
PDB IDs		1AQC 1U37 1U38 1U39 1U3B 1X11 1X45 1Y7N
Enriched GO Terms of Interacting Partners?		Secretion Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Secretion By Cell Neurotransmitter Transport Cell-cell Signaling Synaptic Transmission Establishment Of Localization In Cell Transport Cellular Localization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Synaptic Transmission Exocytosis Cell Adhesion Ion Transport Regulation Of Grooming Behavior Metal Ion Transport Vesicle Localization Regulation Of Peptide Hormone Secretion Regulation Of Synaptic Vesicle Priming Establishment Of Protein Localization Dicarboxylic Acid Transport Regulation Of Hormone Secretion Regulation Of Membrane Potential Behavior Regulation Of Secretion Synaptic Vesicle Transport Cation Transport Regulation Of Receptor Activity Membrane Depolarization Notch Receptor Processing Extracellular Matrix Organization Extracellular Structure Organization Protein Localization Notch Signaling Pathway Glutamate Secretion Organelle Localization Regulation Of Ion Transmembrane Transport Regulation Of Exocytosis Amino Acid Transport Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Single-organism Behavior Vesicle-mediated Transport Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Behavior Calcium Ion Import Regulation Of Synaptic Vesicle Exocytosis Regulation Of Signaling	Activation Of JNKK Activity Activation Of JUN Kinase Activity Activation Of MAPKK Activity Positive Regulation Of JUN Kinase Activity Regulation Of JUN Kinase Activity JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Activation Of MAPK Activity Regulation Of JNK Cascade Ribosomal Small Subunit Export From Nucleus Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Metabolic Process Gamma-aminobutyric Acid Secretion Regulation Of Metabolic Process Protein Autophosphorylation Positive Regulation Of MAP Kinase Activity MAPK Cascade Negative Regulation Of Transcription, DNA-templated Ribosomal Large Subunit Export From Nucleus Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Activation Of Protein Kinase Activity Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Regulation Of MAP Kinase Activity Ribosomal Subunit Export From Nucleus Gamma-aminobutyric Acid Transport Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Regulation Of Histone H3-K4 Methylation Positive Regulation Of Kinase Activity Glutamate Secretion Regulation Of Protein Export From Nucleus Intracellular Transport Of Virus Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transferase Activity Protein Export From Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Regulation Of MAPK Cascade Regulation Of Centrosome Duplication Positive Regulation Of Cell Death
Tagcloud ?		abpa1 cask compromised consisting cortical distinctly dysregulated glutamate hypofunction involve kif17 layer mediating microtubule mlin7 mlin7a mlin7c neurotransmission nmda nr2a nr2b overlapped pathophysiology postmortem prominent schizophrenia separate trafficking transcripts	calmodulin camk cargo compartments complexity confinement conversely dendrites dendritic distances dramatically exits kinesin locally mobile nascent processed regimes restricts scales secretory segments spatial spatially tight trafficking transported tuned zones
Tagcloud (Difference) ?		abpa1 cask compromised consisting cortical distinctly dysregulated glutamate hypofunction involve layer mediating microtubule mlin7 mlin7a mlin7c neurotransmission nmda nr2a nr2b overlapped pathophysiology postmortem prominent schizophrenia separate transcripts	calmodulin camk cargo compartments complexity confinement conversely dendrites dendritic distances dramatically exits kinesin locally mobile nascent processed regimes restricts scales secretory segments spatial spatially tight transported tuned zones
Tagcloud (Intersection) ?		kif17 trafficking