HTR2C and DLG4

Number of citations of the paper that reports this interaction (PMID 12006486)
23

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		HTR2C	DLG4
Gene Name		5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	discs, large homolog 4 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Endoplasmic Reticulum Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Cell Junction Endocytic Vesicle Membrane Cortical Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Dendrite Cytoplasm Dendritic Spine Juxtaparanode Region Of Axon Cerebellar Mossy Fiber Neuron Projection Terminus Neuron Spine Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity Serotonin Receptor Activity Drug Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Protein Phosphatase Binding PDZ Domain Binding Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding P2Y1 Nucleotide Receptor Binding Protein Complex Binding Acetylcholine Receptor Binding Ionotropic Glutamate Receptor Binding Scaffold Protein Binding
	Biological Process	Behavioral Fear Response CGMP Biosynthetic Process Cellular Calcium Ion Homeostasis Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Neurological System Process Regulation Of Appetite Response To Drug Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade	Negative Regulation Of Receptor Internalization Protein Complex Assembly Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Nervous System Development Axon Guidance Learning Synaptic Vesicle Maturation Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Establishment Of Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance Dendritic Spine Morphogenesis Vocalization Behavior Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Receptor Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Grooming Behavior
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Serotonin receptors	Axon guidance L1CAM interactions Activation of Kainate Receptors upon glutamate binding CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII NrCAM interactions Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Activation of Ca-permeable Kainate Receptor Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		Tramadol Ziprasidone Methysergide Cabergoline Ropinirole Olanzapine Clozapine Mirtazapine Loxapine Pramipexole Promazine Cyproheptadine Fenfluramine Lisuride Trazodone Apomorphine Risperidone Propiomazine Minaprine Tegaserod Doxepin Nefazodone Pergolide Dexfenfluramine Bromocriptine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine 3,4-Methylenedioxymethamphetamine Lorcaserin Sertindole Mianserin Asenapine Agomelatine
Diseases
GWAS			Liver enzyme levels (alkaline phosphatase) ( 22001757)
Protein-Protein Interactions		8 interactors: APBA1 ARRB2 CALM1 DLG4 GNAQ LIN7C MPDZ SNTA1	104 interactors: ACTN2 ADRB1 AKAP5 ARHGAP32 ASIC3 ATP2B2 ATP2B4 BAI1 BEGAIN CACNG2 CASK CD46 CIT CNKSR2 CRIPT DLG2 DLG3 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DYNLL1 EFNB2 ERBB2 ERBB2IP ERBB4 EXOC4 FYN FZD1 FZD2 FZD4 FZD7 GDA GLS2 GNG13 GRASP GRIK1 GRIK2 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GUCY1A2 HGS HTR2A HTR2C HTT IL13RA1 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCND2 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF13B KIF1B LIN7A LIN7B LPHN1 LRFN1 LRP1 LRP2 LRP8 LRRC1 LYN MAP1A MAP3K10 MAPK12 MDM2 NCKIPSD NDOR1 NLGN1 NLGN2 NLGN3 NLGN4X NOS1 PCDH10 PRKCA PTK2B PTPRG SCN5A SEMA4B SEMA4C SEMA4F SEMA4G SHANK1 SHANK2 SIPA1L1 SPRR2A SRC SYNGAP1 TANC1 WNT3A YES1 ZDHHC17
Entrez ID		3358	1742
HPRD ID		02429	04199
Ensembl ID		ENSG00000147246	ENSG00000132535
Uniprot IDs		K9J958 P28335	B7Z647 B9EGL1 P78352
PDB IDs			1KEF 3I4W 3K82 3ZRT
Enriched GO Terms of Interacting Partners?		Maintenance Of Apical/basal Cell Polarity Maintenance Of Cell Polarity Secretion By Cell Nervous System Development Behavior Platelet Activation Regulation Of Ion Transport Secretion Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Receptor Internalization Locomotory Behavior Regulation Of Membrane Potential Negative Regulation Of Cellular Protein Metabolic Process Anatomical Structure Development Negative Regulation Of Protein Metabolic Process Activation Of Phospholipase C Activity Cell-cell Signaling Exocytosis Positive Regulation Of Phospholipase C Activity Developmental Process Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Phospholipase Activity Regulation Of Ion Transmembrane Transport Blood Coagulation Hemostasis Regulation Of Vasoconstriction By Circulating Norepinephrine Regulation Of Phospholipase Activity Regulation Of Striated Muscle Contraction Action Potential Positive Regulation Of Lipase Activity Positive Regulation Of Calcium Ion Transport Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Synaptic Transmission System Development Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway By Arrestin Regulation Of Body Fluid Levels Synaptic Transmission Vesicle-mediated Transport Wound Healing Establishment Of Protein Localization Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Activation Regulation Of Muscle Contraction Multicellular Organismal Development Response To Wounding Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity	Cell-cell Signaling Synaptic Transmission Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Ion Transmembrane Transport Membrane Depolarization Nervous System Development Regulation Of Postsynaptic Membrane Potential Regulation Of Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Neurological System Process Neuron-neuron Synaptic Transmission Glutamate Receptor Signaling Pathway Signal Transduction Metal Ion Transport Synaptic Transmission, Glutamatergic Neurogenesis Response To Stimulus Ion Transport Generation Of Neurons Cellular Response To Stimulus Transport System Development Cation Transport Cell Surface Receptor Signaling Pathway Single-organism Behavior Sensory Perception Of Pain Behavior Neuron Differentiation Regulation Of Signal Transduction Response To Abiotic Stimulus Ion Transmembrane Transport Regulation Of Cellular Localization Anatomical Structure Development Regulation Of Cellular Process Membrane Hyperpolarization Cell Differentiation Cation Transmembrane Transport Multicellular Organismal Development Developmental Process Regulation Of Phosphorus Metabolic Process Learning Response To External Stimulus Cellular Process Neuron Development Positive Regulation Of Signal Transduction
Tagcloud ?		accessible becoming bioinformatics c10orf26 cacna1c circuitry csmd1 ephrin erbb4 freely gabra1 grin2a grm5 gsk3b guidance ingenuity ipa nrg2 ns polygenic schizophrenia searches silence szgr targetscan tcf4 thousands top znf804a	6g1 alleviated amyloid ca1 counteract densities distant fibrillar immunohistochemically immunotherapy oligomer oligomeric oligomers plaque plaques presynapses psd95 quantified reservoirs sequestering suffices synapse synapses synapsin synaptotoxic tg2576 unchanged unspecific vicinity
Tagcloud (Difference) ?		accessible becoming bioinformatics c10orf26 cacna1c circuitry csmd1 ephrin erbb4 freely gabra1 grin2a grm5 gsk3b guidance ingenuity ipa nrg2 ns polygenic schizophrenia searches silence szgr targetscan tcf4 thousands top znf804a	6g1 alleviated amyloid ca1 counteract densities distant fibrillar immunohistochemically immunotherapy oligomer oligomeric oligomers plaque plaques presynapses psd95 quantified reservoirs sequestering suffices synapse synapses synapsin synaptotoxic tg2576 unchanged unspecific vicinity
Tagcloud (Intersection) ?