CFH and ADM

Number of citations of the paper that reports this interaction (PMID 11116141)
37

Data Source:
HPRD (in vitro)

		CFH	ADM
Gene Name		complement factor H	adrenomedullin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding	Receptor Binding Hormone Activity Protein Binding Adrenomedullin Receptor Binding
	Biological Process	Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Innate Immune Response	Vasculogenesis Response To Hypoxia Neural Tube Closure Regulation Of The Force Of Heart Contraction G-protein Coupled Receptor Internalization CAMP Biosynthetic Process Progesterone Biosynthetic Process Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Heart Development Female Pregnancy Aging Blood Circulation Androgen Metabolic Process Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Cold Response To Wounding Positive Regulation Of Heart Rate CAMP-mediated Signaling Positive Regulation Of CAMP Biosynthetic Process Organ Regeneration Neuron Projection Regeneration Receptor Internalization Response To Lipopolysaccharide Response To Insulin Odontogenesis Of Dentin-containing Tooth Response To Starvation Positive Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Hormone Secretion Developmental Growth Response To Glucocorticoid Branching Involved In Labyrinthine Layer Morphogenesis Spongiotrophoblast Layer Development Vascular Smooth Muscle Cell Development Positive Regulation Of Vasculogenesis
Pathways		Regulation of Complement cascade Complement cascade Innate Immune System	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23577725 23455636 23536807 20861866 21665990 15761122) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (GA) ( 22705344) Circulating myeloperoxidase levels (serum) ( 23620142) Complement C3 and C4 levels ( 23028341) Meningococcal disease ( 20694013) Nephropathy ( 21399633)	Blood pressure ( 21909110) Circulating vasoactive peptide levels ( 23381795) Diastolic blood pressure ( 21909115) HDL cholesterol ( 20686565) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		16 interactors: ADM C3 CFHR1 CFI CRP DMP1 EP300 GRB2 ITGAM PTX3 SELL SMAD3 THBS1 VDR YTHDC1 ZBTB16	4 interactors: CALCRL CFH EDN1 MME
Entrez ID		3075	133
HPRD ID		00601	00061
Ensembl ID		ENSG00000000971
Uniprot IDs		F8WDX4 P08603	P35318
PDB IDs		1FHC 1HAQ 1HCC 1HFH 1HFI 1KOV 2BZM 2G7I 2IC4 2JGW 2JGX 2KMS 2QFG 2QFH 2RLP 2RLQ 2UWN 2V8E 2W80 2W81 2WII 2XQW 3GAU 3GAV 3GAW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4B2R 4B2S 4J38	2FLY 2L7S
Enriched GO Terms of Interacting Partners?		Immune System Process Immune Response Regulation Of Immune System Process Tissue Development Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Wounding Positive Regulation Of Reactive Oxygen Species Metabolic Process Defense Response Positive Regulation Of Cellular Metabolic Process Response To Hypoxia Response To Stress Wound Healing Complement Activation Positive Regulation Of Immune Response Endocytosis Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Cell Adhesion Organ Development Protein Activation Cascade Inflammatory Response Response To External Stimulus System Development Innate Immune Response Positive Regulation Of Metabolic Process Humoral Immune Response Response To Organic Cyclic Compound Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Cytokine Production Opsonization Phagocytosis Regulation Of Body Fluid Levels Organ Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cell Adhesion Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Development Epithelium Development Response To Abiotic Stimulus Negative Regulation Of Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Morphogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Cytokine Production Complement Activation, Classical Pathway	Positive Regulation Of Smooth Muscle Cell Proliferation Sensory Perception Of Pain Regulation Of CAMP Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure Regulation Of CAMP Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Phospholipase D-activating G-protein Coupled Receptor Signaling Pathway Cellular Response To Sucrose Stimulus Protein Kinase C Deactivation Regulation Of Muscle Contraction Cellular Response To Mineralocorticoid Stimulus Response To Salt Rhythmic Excitation Regulation Of Blood Pressure Cellular Response To UV-A Nitric Oxide Transport Response To Prostaglandin F Positive Regulation Of Chemokine-mediated Signaling Pathway Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Vein Smooth Muscle Contraction Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Regulation Of Hormone Levels Regulation Of Systemic Arterial Blood Pressure By Endothelin Epithelial Fluid Transport Creatinine Metabolic Process Regulation Of Inflammatory Response Positive Regulation Of Sarcomere Organization Rhythmic Synaptic Transmission Response To UV-A Blood Circulation Response To Ozone Negative Regulation Of Smooth Muscle Cell Apoptotic Process Aging Angiogenesis Cellular Response To UV-B Artery Smooth Muscle Contraction Response To Muscle Stretch Tonic Smooth Muscle Contraction Maternal Process Involved In Parturition Positive Regulation Of Receptor Biosynthetic Process Positive Regulation Of Odontogenesis Angiotensin Maturation Cellular Response To Organic Substance Blood Vessel Morphogenesis Regulation Of Angiotensin Metabolic Process Complement Activation, Alternative Pathway Positive Regulation Of Renal Sodium Excretion Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Positive Regulation Of Prostaglandin Secretion
Tagcloud ?		bands blue carcinoscorpius concerted converted crab crabs denaturation detoxification dosage fatalities fluorescent haemolymph horseshoe intracardially ld50 neutralization neutralizing page proteinaceous reacted rotundicauda sds spot tetrodotoxin tlc ttx wts yellow	7mg adriamycin cap cddp clinic cpm cr cyclophosphamide d1 d10 divided home hrs infusion nausea nephrotoxicities ns outpatient ovarian pr remarkably saline schedule schedules side sqm suitable twenty vomiting
Tagcloud (Difference) ?		bands blue carcinoscorpius concerted converted crab crabs denaturation detoxification dosage fatalities fluorescent haemolymph horseshoe intracardially ld50 neutralization neutralizing page proteinaceous reacted rotundicauda sds spot tetrodotoxin tlc ttx wts yellow	7mg adriamycin cap cddp clinic cpm cr cyclophosphamide d1 d10 divided home hrs infusion nausea nephrotoxicities ns outpatient ovarian pr remarkably saline schedule schedules side sqm suitable twenty vomiting
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