CFH and PTX3

Number of citations of the paper that reports this interaction (PMID 19050261)
16

Data Source:
HPRD (in vitro)

		CFH	PTX3
Gene Name		complement factor H	pentraxin 3, long
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding	Complement Component C1q Binding (1->3)-beta-D-glucan Binding Virion Binding
	Biological Process	Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Innate Immune Response	Response To Yeast Inflammatory Response Opsonization Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Phagocytosis Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process
Pathways		Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23577725 23455636 23536807 20861866 21665990 15761122) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (GA) ( 22705344) Circulating myeloperoxidase levels (serum) ( 23620142) Complement C3 and C4 levels ( 23028341) Meningococcal disease ( 20694013) Nephropathy ( 21399633)
Protein-Protein Interactions		16 interactors: ADM C3 CFHR1 CFI CRP DMP1 EP300 GRB2 ITGAM PTX3 SELL SMAD3 THBS1 VDR YTHDC1 ZBTB16	5 interactors: C1QA C1QB C1QC CFH FGF2
Entrez ID		3075	5806
HPRD ID		00601	03928
Ensembl ID		ENSG00000000971	ENSG00000163661
Uniprot IDs		F8WDX4 P08603	P26022
PDB IDs		1FHC 1HAQ 1HCC 1HFH 1HFI 1KOV 2BZM 2G7I 2IC4 2JGW 2JGX 2KMS 2QFG 2QFH 2RLP 2RLQ 2UWN 2V8E 2W80 2W81 2WII 2XQW 3GAU 3GAV 3GAW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4B2R 4B2S 4J38
Enriched GO Terms of Interacting Partners?		Immune System Process Immune Response Regulation Of Immune System Process Tissue Development Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Wounding Positive Regulation Of Reactive Oxygen Species Metabolic Process Defense Response Positive Regulation Of Cellular Metabolic Process Response To Hypoxia Response To Stress Wound Healing Complement Activation Positive Regulation Of Immune Response Endocytosis Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Cell Adhesion Organ Development Protein Activation Cascade Inflammatory Response Response To External Stimulus System Development Innate Immune Response Positive Regulation Of Metabolic Process Humoral Immune Response Response To Organic Cyclic Compound Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Cytokine Production Opsonization Phagocytosis Regulation Of Body Fluid Levels Organ Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cell Adhesion Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Development Epithelium Development Response To Abiotic Stimulus Negative Regulation Of Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Morphogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Cytokine Production Complement Activation, Classical Pathway	Complement Activation Protein Activation Cascade Humoral Immune Response Innate Immune Response Regulation Of Immune Response Immune Response Regulation Of Immune System Process Defense Response Complement Activation, Classical Pathway Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Immune Response Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Immune System Process Positive Regulation Of Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Leukocyte Mediated Immunity Adaptive Immune Response Response To Stress Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Cell Fate Specification Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Chondroblast Differentiation Inositol Phosphate Biosynthetic Process Regulation Of Satellite Cell Proliferation Negative Regulation Of Granulocyte Differentiation Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Macrophage Differentiation Complement Activation, Alternative Pathway Negative Regulation Of Fibroblast Migration Hyaluronan Catabolic Process Positive Regulation Of Cell Fate Commitment Regulation Of Sprouting Angiogenesis Regulation Of Cell Fate Specification Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Cell Migration Involved In Sprouting Angiogenesis Response To Stimulus Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Chemotaxis Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Fibroblast Migration Blood Vessel Endothelial Cell Migration Regulation Of Complement Activation Regulation Of Cell Fate Commitment Negative Regulation Of Endothelial Cell Migration Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Heart Growth
Tagcloud ?		bands blue carcinoscorpius concerted converted crab crabs denaturation detoxification dosage fatalities fluorescent haemolymph horseshoe intracardially ld50 neutralization neutralizing page proteinaceous reacted rotundicauda sds spot tetrodotoxin tlc ttx wts yellow	0288mg 072pg 161mg 161pg 1beta accumulating beta1 contributes crp daily diverse divided ds enrolled epilepsy frequent generalized hs inflammatory intermittent intractable motor organs pathomechanism pathophysiology pentraxin presenting seizures treat
Tagcloud (Difference) ?		bands blue carcinoscorpius concerted converted crab crabs denaturation detoxification dosage fatalities fluorescent haemolymph horseshoe intracardially ld50 neutralization neutralizing page proteinaceous reacted rotundicauda sds spot tetrodotoxin tlc ttx wts yellow	0288mg 072pg 161mg 161pg 1beta accumulating beta1 contributes crp daily diverse divided ds enrolled epilepsy frequent generalized hs inflammatory intermittent intractable motor organs pathomechanism pathophysiology pentraxin presenting seizures treat
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