ADM and CALCRL

Number of citations of the paper that reports this interaction (PMID 9620797)
228

Data Source:
HPRD (in vitro, in vivo)

		ADM	CALCRL
Gene Name		adrenomedullin	calcitonin receptor-like
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Lysosome Endosome Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Receptor Binding Hormone Activity Protein Binding Adrenomedullin Receptor Binding	Adrenomedullin Receptor Activity Calcitonin Gene-related Peptide Receptor Activity G-protein Coupled Receptor Activity Calcitonin Receptor Activity Protein Binding Protein Transporter Activity
	Biological Process	Vasculogenesis Response To Hypoxia Neural Tube Closure Regulation Of The Force Of Heart Contraction G-protein Coupled Receptor Internalization CAMP Biosynthetic Process Progesterone Biosynthetic Process Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Heart Development Female Pregnancy Aging Blood Circulation Androgen Metabolic Process Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Cold Response To Wounding Positive Regulation Of Heart Rate CAMP-mediated Signaling Positive Regulation Of CAMP Biosynthetic Process Organ Regeneration Neuron Projection Regeneration Receptor Internalization Response To Lipopolysaccharide Response To Insulin Odontogenesis Of Dentin-containing Tooth Response To Starvation Positive Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Hormone Secretion Developmental Growth Response To Glucocorticoid Branching Involved In Labyrinthine Layer Morphogenesis Spongiotrophoblast Layer Development Vascular Smooth Muscle Cell Development Positive Regulation Of Vasculogenesis	Angiogenesis CAMP Biosynthetic Process Calcium Ion Transport Regulation Of Muscle Contraction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Heart Development Protein Transport Positive Regulation Of CAMP Biosynthetic Process Receptor Internalization Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Cellular Response To Sucrose Stimulus
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Blood pressure ( 21909110) Circulating vasoactive peptide levels ( 23381795) Diastolic blood pressure ( 21909115) HDL cholesterol ( 20686565) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		4 interactors: CALCRL CFH EDN1 MME	6 interactors: ADM CALCA CRCP RAMP1 RAMP2 RAMP3
Entrez ID		133	10203
HPRD ID		00061	11809
Ensembl ID			ENSG00000064989
Uniprot IDs		P35318	Q16602
PDB IDs		2FLY 2L7S	3AQF 3N7P 3N7R 3N7S
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Smooth Muscle Cell Proliferation Sensory Perception Of Pain Regulation Of CAMP Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure Regulation Of CAMP Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Phospholipase D-activating G-protein Coupled Receptor Signaling Pathway Cellular Response To Sucrose Stimulus Protein Kinase C Deactivation Regulation Of Muscle Contraction Cellular Response To Mineralocorticoid Stimulus Response To Salt Rhythmic Excitation Regulation Of Blood Pressure Cellular Response To UV-A Nitric Oxide Transport Response To Prostaglandin F Positive Regulation Of Chemokine-mediated Signaling Pathway Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Vein Smooth Muscle Contraction Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Regulation Of Hormone Levels Regulation Of Systemic Arterial Blood Pressure By Endothelin Epithelial Fluid Transport Creatinine Metabolic Process Regulation Of Inflammatory Response Positive Regulation Of Sarcomere Organization Rhythmic Synaptic Transmission Response To UV-A Blood Circulation Response To Ozone Negative Regulation Of Smooth Muscle Cell Apoptotic Process Aging Angiogenesis Cellular Response To UV-B Artery Smooth Muscle Contraction Response To Muscle Stretch Tonic Smooth Muscle Contraction Maternal Process Involved In Parturition Positive Regulation Of Receptor Biosynthetic Process Positive Regulation Of Odontogenesis Angiotensin Maturation Cellular Response To Organic Substance Blood Vessel Morphogenesis Regulation Of Angiotensin Metabolic Process Complement Activation, Alternative Pathway Positive Regulation Of Renal Sodium Excretion Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Positive Regulation Of Prostaglandin Secretion	Receptor Internalization Receptor Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Receptor-mediated Endocytosis Regulation Of CAMP Metabolic Process Endocytosis Vascular Smooth Muscle Cell Development G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Vasculogenesis Negative Regulation Of Vascular Permeability G-protein Coupled Receptor Internalization Vasculature Development Regulation Of Vasculogenesis Vesicle-mediated Transport Protein Localization To Plasma Membrane Vascular Smooth Muscle Cell Differentiation Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway CAMP Biosynthetic Process Plasma Membrane Organization Female Pregnancy Regulation Of Vascular Permeability Positive Regulation Of Vasodilation Cardiovascular System Development CAMP Metabolic Process Blood Circulation Calcium Ion Transport Cyclic Purine Nucleotide Metabolic Process Regulation Of Vasodilation Protein Localization To Membrane Cyclic Nucleotide Biosynthetic Process Smooth Muscle Cell Differentiation Positive Regulation Of Cellular Metabolic Process Blood Vessel Morphogenesis Endomembrane System Organization Regulation Of Signal Transduction Signal Transduction Regulation Of Heart Rate Cyclic Nucleotide Metabolic Process Response To Steroid Hormone Signaling Blood Vessel Development Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Cell Communication Cell Surface Receptor Signaling Pathway Neuropeptide Signaling Pathway
Tagcloud ?		7mg adriamycin cap cddp clinic cpm cr cyclophosphamide d1 d10 divided home hrs infusion nausea nephrotoxicities ns outpatient ovarian pr remarkably saline schedule schedules side sqm suitable twenty vomiting
Tagcloud (Difference) ?		7mg adriamycin cap cddp clinic cpm cr cyclophosphamide d1 d10 divided home hrs infusion nausea nephrotoxicities ns outpatient ovarian pr remarkably saline schedule schedules side sqm suitable twenty vomiting
Tagcloud (Intersection) ?