ADM and MME

Number of citations of the paper that reports this interaction (PMID 8687431)
2

Data Source:
HPRD (in vitro)

		ADM	MME
Gene Name		adrenomedullin	membrane metallo-endopeptidase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Integral Component Of Membrane Axon Dendrite Neuron Projection Terminus Synapse Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Hormone Activity Protein Binding Adrenomedullin Receptor Binding	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Exopeptidase Activity Zinc Ion Binding Peptide Binding
	Biological Process	Vasculogenesis Response To Hypoxia Neural Tube Closure Regulation Of The Force Of Heart Contraction G-protein Coupled Receptor Internalization CAMP Biosynthetic Process Progesterone Biosynthetic Process Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Heart Development Female Pregnancy Aging Blood Circulation Androgen Metabolic Process Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Cold Response To Wounding Positive Regulation Of Heart Rate CAMP-mediated Signaling Positive Regulation Of CAMP Biosynthetic Process Organ Regeneration Neuron Projection Regeneration Receptor Internalization Response To Lipopolysaccharide Response To Insulin Odontogenesis Of Dentin-containing Tooth Response To Starvation Positive Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Hormone Secretion Developmental Growth Response To Glucocorticoid Branching Involved In Labyrinthine Layer Morphogenesis Spongiotrophoblast Layer Development Vascular Smooth Muscle Cell Development Positive Regulation Of Vasculogenesis	Kidney Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Sensory Perception Of Pain Cellular Protein Metabolic Process Creatinine Metabolic Process Beta-amyloid Metabolic Process Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins
Drugs			Candoxatril N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1\'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan
Diseases
GWAS		Blood pressure ( 21909110) Circulating vasoactive peptide levels ( 23381795) Diastolic blood pressure ( 21909115) HDL cholesterol ( 20686565) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		4 interactors: CALCRL CFH EDN1 MME	16 interactors: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 SHC1 VIP
Entrez ID		133	4311
HPRD ID		00061	00392
Ensembl ID			ENSG00000196549
Uniprot IDs		P35318	P08473
PDB IDs		2FLY 2L7S	1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Smooth Muscle Cell Proliferation Sensory Perception Of Pain Regulation Of CAMP Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure Regulation Of CAMP Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Phospholipase D-activating G-protein Coupled Receptor Signaling Pathway Cellular Response To Sucrose Stimulus Protein Kinase C Deactivation Regulation Of Muscle Contraction Cellular Response To Mineralocorticoid Stimulus Response To Salt Rhythmic Excitation Regulation Of Blood Pressure Cellular Response To UV-A Nitric Oxide Transport Response To Prostaglandin F Positive Regulation Of Chemokine-mediated Signaling Pathway Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Vein Smooth Muscle Contraction Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Regulation Of Hormone Levels Regulation Of Systemic Arterial Blood Pressure By Endothelin Epithelial Fluid Transport Creatinine Metabolic Process Regulation Of Inflammatory Response Positive Regulation Of Sarcomere Organization Rhythmic Synaptic Transmission Response To UV-A Blood Circulation Response To Ozone Negative Regulation Of Smooth Muscle Cell Apoptotic Process Aging Angiogenesis Cellular Response To UV-B Artery Smooth Muscle Contraction Response To Muscle Stretch Tonic Smooth Muscle Contraction Maternal Process Involved In Parturition Positive Regulation Of Receptor Biosynthetic Process Positive Regulation Of Odontogenesis Angiotensin Maturation Cellular Response To Organic Substance Blood Vessel Morphogenesis Regulation Of Angiotensin Metabolic Process Complement Activation, Alternative Pathway Positive Regulation Of Renal Sodium Excretion Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Positive Regulation Of Prostaglandin Secretion	Positive Regulation Of Vasodilation Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Vasodilation Signaling Cell Communication Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Response To Stimulus Response To Hormone Positive Regulation Of Heart Contraction Cell Activation Positive Regulation Of Metabolic Process Regulation Of CAMP Metabolic Process Response To Peptide Hormone Artery Smooth Muscle Contraction Response To Peptide Regulation Of Kinase Activity Tonic Smooth Muscle Contraction Positive Regulation Of Protein Metabolic Process Response To Insulin Cellular Chemical Homeostasis Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Second-messenger-mediated Signaling Blood Circulation Response To External Stimulus Intracellular Signal Transduction Response To Stimulus Cellular Response To Hormone Stimulus Response To Organic Substance Regulation Of Vasoconstriction Positive Regulation Of Cellular Metabolic Process Vascular Smooth Muscle Contraction Histamine Secretion Negative Regulation Of Cell Proliferation Regulation Of Signal Transduction Cellular Homeostasis Regulation Of Heart Rate Cellular Metal Ion Homeostasis Response To Abiotic Stimulus Phosphate-containing Compound Metabolic Process Histamine Transport Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Multicellular Organismal Development
Tagcloud ?		7mg adriamycin cap cddp clinic cpm cr cyclophosphamide d1 d10 divided home hrs infusion nausea nephrotoxicities ns outpatient ovarian pr remarkably saline schedule schedules side sqm suitable twenty vomiting	adh alb albinism arbitrarily assortment backcrossing constitution duplicate electrophoretically fumarate glo glucosephosphate glyoxalase gpd homeologous hydratase intersubspecies isocitrate malic mannosephosphate midh mpi numbered phosphorylase provisionally sme sorbitol sord ssod
Tagcloud (Difference) ?		7mg adriamycin cap cddp clinic cpm cr cyclophosphamide d1 d10 divided home hrs infusion nausea nephrotoxicities ns outpatient ovarian pr remarkably saline schedule schedules side sqm suitable twenty vomiting	adh alb albinism arbitrarily assortment backcrossing constitution duplicate electrophoretically fumarate glo glucosephosphate glyoxalase gpd homeologous hydratase intersubspecies isocitrate malic mannosephosphate midh mpi numbered phosphorylase provisionally sme sorbitol sord ssod
Tagcloud (Intersection) ?