CFH and CFI

Number of citations of the paper that reports this interaction (PMID 1401896)
29

Data Source:
HPRD (in vitro)

		CFH	CFI
Gene Name		complement factor H	complement factor I
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome Blood Microparticle	Extracellular Region Extracellular Space Nucleus Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding	Serine-type Endopeptidase Activity Scavenger Receptor Activity Metal Ion Binding
	Biological Process	Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Innate Immune Response	Proteolysis Receptor-mediated Endocytosis Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response
Pathways		Regulation of Complement cascade Complement cascade Innate Immune System	Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23577725 23455636 23536807 20861866 21665990 15761122) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (GA) ( 22705344) Circulating myeloperoxidase levels (serum) ( 23620142) Complement C3 and C4 levels ( 23028341) Meningococcal disease ( 20694013) Nephropathy ( 21399633)	Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Age-related macular degeneration (GA) ( 22705344)
Protein-Protein Interactions		16 interactors: ADM C3 CFHR1 CFI CRP DMP1 EP300 GRB2 ITGAM PTX3 SELL SMAD3 THBS1 VDR YTHDC1 ZBTB16	3 interactors: C3 CFH GLP1R
Entrez ID		3075	3426
HPRD ID		00601	01955
Ensembl ID		ENSG00000000971	ENSG00000205403
Uniprot IDs		F8WDX4 P08603	A8K3L0 E7ETH0 G3XAM2 P05156
PDB IDs		1FHC 1HAQ 1HCC 1HFH 1HFI 1KOV 2BZM 2G7I 2IC4 2JGW 2JGX 2KMS 2QFG 2QFH 2RLP 2RLQ 2UWN 2V8E 2W80 2W81 2WII 2XQW 3GAU 3GAV 3GAW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4B2R 4B2S 4J38	2XRC
Enriched GO Terms of Interacting Partners?		Immune System Process Immune Response Regulation Of Immune System Process Tissue Development Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Wounding Positive Regulation Of Reactive Oxygen Species Metabolic Process Defense Response Positive Regulation Of Cellular Metabolic Process Response To Hypoxia Response To Stress Wound Healing Complement Activation Positive Regulation Of Immune Response Endocytosis Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Cell Adhesion Organ Development Protein Activation Cascade Inflammatory Response Response To External Stimulus System Development Innate Immune Response Positive Regulation Of Metabolic Process Humoral Immune Response Response To Organic Cyclic Compound Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Cytokine Production Opsonization Phagocytosis Regulation Of Body Fluid Levels Organ Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cell Adhesion Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Development Epithelium Development Response To Abiotic Stimulus Negative Regulation Of Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Morphogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Cytokine Production Complement Activation, Classical Pathway	Complement Activation, Alternative Pathway Regulation Of Complement Activation Regulation Of Humoral Immune Response Regulation Of Acute Inflammatory Response Complement Activation Protein Activation Cascade Positive Regulation Of Type IIa Hypersensitivity Humoral Immune Response Regulation Of Inflammatory Response Positive Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Hypersensitivity Regulation Of Protein Processing Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Apoptotic Cell Clearance Positive Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Positive Regulation Of Immune Response Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Protein Processing Regulation Of Triglyceride Biosynthetic Process CAMP-mediated Signaling Response To Stress Positive Regulation Of Acute Inflammatory Response Innate Immune Response Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Regulation Of Immune Response Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Lipid Storage Positive Regulation Of Immune System Process Regulation Of Triglyceride Metabolic Process Positive Regulation Of Immunoglobulin Mediated Immune Response Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Lyase Activity Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Phagocytosis Positive Regulation Of Glucose Transport Response To Glucagon G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Regulation Of Lipid Storage Positive Regulation Of CAMP Biosynthetic Process Regulation Of Phagocytosis Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Immune Response Regulation Of Immune System Process Defense Response
Tagcloud ?		bands blue carcinoscorpius concerted converted crab crabs denaturation detoxification dosage fatalities fluorescent haemolymph horseshoe intracardially ld50 neutralization neutralizing page proteinaceous reacted rotundicauda sds spot tetrodotoxin tlc ttx wts yellow	agfi amos autonomic c30 cipn cipn20 concurrent confirmatory consistency convenience cronbach eortc fill gfi items korean loadings neuropathy neurotoxic nfi qlq reliability rmsr satisfactory spss subscale subscales validity version
Tagcloud (Difference) ?		bands blue carcinoscorpius concerted converted crab crabs denaturation detoxification dosage fatalities fluorescent haemolymph horseshoe intracardially ld50 neutralization neutralizing page proteinaceous reacted rotundicauda sds spot tetrodotoxin tlc ttx wts yellow	agfi amos autonomic c30 cipn cipn20 concurrent confirmatory consistency convenience cronbach eortc fill gfi items korean loadings neuropathy neurotoxic nfi qlq reliability rmsr satisfactory spss subscale subscales validity version
Tagcloud (Intersection) ?