CFH and CFHR1

Number of citations of the paper that reports this interaction (PMID 8663389)
15

Data Source:
HPRD (in vivo)

		CFH	CFHR1
Gene Name		complement factor H	complement factor H-related 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Vesicular Exosome Blood Microparticle	Extracellular Space Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Complement Activation Complement Activation, Alternative Pathway Regulation Of Complement Activation Innate Immune Response	Complement Activation
Pathways		Regulation of Complement cascade Complement cascade Innate Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23577725 23455636 23536807 20861866 21665990 15761122) Age-related macular degeneration (CNV) ( 22705344) Age-related macular degeneration (extreme sampling) ( 23577725) Age-related macular degeneration (GA) ( 22705344) Circulating myeloperoxidase levels (serum) ( 23620142) Complement C3 and C4 levels ( 23028341) Meningococcal disease ( 20694013) Nephropathy ( 21399633)	Complement C3 and C4 levels ( 23028341) Nephropathy ( 21399633)
Protein-Protein Interactions		16 interactors: ADM C3 CFHR1 CFI CRP DMP1 EP300 GRB2 ITGAM PTX3 SELL SMAD3 THBS1 VDR YTHDC1 ZBTB16	4 interactors: APOA1 CFH LBP PRDX4
Entrez ID		3075	3078
HPRD ID		00601	00602
Ensembl ID		ENSG00000000971	ENSG00000244414
Uniprot IDs		F8WDX4 P08603	Q03591
PDB IDs		1FHC 1HAQ 1HCC 1HFH 1HFI 1KOV 2BZM 2G7I 2IC4 2JGW 2JGX 2KMS 2QFG 2QFH 2RLP 2RLQ 2UWN 2V8E 2W80 2W81 2WII 2XQW 3GAU 3GAV 3GAW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4B2R 4B2S 4J38	3ZD2
Enriched GO Terms of Interacting Partners?		Immune System Process Immune Response Regulation Of Immune System Process Tissue Development Regulation Of Immune Response Positive Regulation Of Immune System Process Response To Wounding Positive Regulation Of Reactive Oxygen Species Metabolic Process Defense Response Positive Regulation Of Cellular Metabolic Process Response To Hypoxia Response To Stress Wound Healing Complement Activation Positive Regulation Of Immune Response Endocytosis Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Cell Adhesion Organ Development Protein Activation Cascade Inflammatory Response Response To External Stimulus System Development Innate Immune Response Positive Regulation Of Metabolic Process Humoral Immune Response Response To Organic Cyclic Compound Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Cytokine Production Opsonization Phagocytosis Regulation Of Body Fluid Levels Organ Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of Gene Expression Multicellular Organismal Development Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cell Adhesion Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Development Epithelium Development Response To Abiotic Stimulus Negative Regulation Of Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell-substrate Adhesion Anatomical Structure Morphogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Cytokine Production Complement Activation, Classical Pathway	Regulation Of Inflammatory Response Negative Regulation Of Cell Adhesion Molecule Production Negative Regulation Of Male Germ Cell Proliferation Regulation Of Immune Response Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Leukocyte Chemotaxis Involved In Inflammatory Response Lipopolysaccharide Transport Negative Regulation Of Interleukin-1 Beta Secretion Negative Regulation Of Cytokine Production Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Regulation Of Male Germ Cell Proliferation Negative Regulation Of Interleukin-1 Secretion Regulation Of Immune System Process High-density Lipoprotein Particle Clearance Lipid Transport Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Protein Oxidation Lipid Localization Positive Regulation Of Respiratory Burst Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Assembly Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Intestinal Cholesterol Absorption Phospholipid Homeostasis Peptidyl-methionine Modification Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Protein Maturation By Protein Folding Opsonization Regulation Of Respiratory Burst Macrophage Activation Involved In Immune Response Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Phospholipid Efflux Complement Activation, Alternative Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Lipoteichoic Acid Detection Of Molecule Of Bacterial Origin Positive Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Interleukin-1 Beta Production I-kappaB Phosphorylation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway High-density Lipoprotein Particle Remodeling Leukocyte Migration Involved In Inflammatory Response
Tagcloud ?		bands blue carcinoscorpius concerted converted crab crabs denaturation detoxification dosage fatalities fluorescent haemolymph horseshoe intracardially ld50 neutralization neutralizing page proteinaceous reacted rotundicauda sds spot tetrodotoxin tlc ttx wts yellow	2d apoa1 apoa4 biochemistry bioinformatic clu cscc curative decyder dige dysfunctional eppk1 erroneous etc f2 igk ingenuity ipa maldi masp2 missed overrepresented proteomic proteomics quantitatively spots suffered urgent uyghur
Tagcloud (Difference) ?		bands blue carcinoscorpius concerted converted crab crabs denaturation detoxification dosage fatalities fluorescent haemolymph horseshoe intracardially ld50 neutralization neutralizing page proteinaceous reacted rotundicauda sds spot tetrodotoxin tlc ttx wts yellow	2d apoa1 apoa4 biochemistry bioinformatic clu cscc curative decyder dige dysfunctional eppk1 erroneous etc f2 igk ingenuity ipa maldi masp2 missed overrepresented proteomic proteomics quantitatively spots suffered urgent uyghur
Tagcloud (Intersection) ?