ADM

Gene Name		adrenomedullin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Receptor Binding Hormone Activity Protein Binding Adrenomedullin Receptor Binding
	Biological Process	Vasculogenesis Response To Hypoxia Neural Tube Closure Regulation Of The Force Of Heart Contraction G-protein Coupled Receptor Internalization CAMP Biosynthetic Process Progesterone Biosynthetic Process Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Heart Development Female Pregnancy Aging Blood Circulation Androgen Metabolic Process Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Cold Response To Wounding Positive Regulation Of Heart Rate CAMP-mediated Signaling Positive Regulation Of CAMP Biosynthetic Process Organ Regeneration Neuron Projection Regeneration Receptor Internalization Response To Lipopolysaccharide Response To Insulin Odontogenesis Of Dentin-containing Tooth Response To Starvation Positive Regulation Of Apoptotic Process Negative Regulation Of Vascular Permeability Positive Regulation Of Angiogenesis Negative Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Hormone Secretion Developmental Growth Response To Glucocorticoid Branching Involved In Labyrinthine Layer Morphogenesis Spongiotrophoblast Layer Development Vascular Smooth Muscle Cell Development Positive Regulation Of Vasculogenesis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Calcitonin-like ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Blood pressure ( 21909110) Circulating vasoactive peptide levels ( 23381795) Diastolic blood pressure ( 21909115) HDL cholesterol ( 20686565) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Systolic blood pressure ( 21909115)
Protein-protein Interactions		4 interactors: CALCRL CFH EDN1 MME
Entrez ID		133
HPRD ID		00061
Ensembl ID
Uniprot IDs		P35318
PDB IDs		2FLY 2L7S
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Smooth Muscle Cell Proliferation Sensory Perception Of Pain Regulation Of CAMP Biosynthetic Process Regulation Of Systemic Arterial Blood Pressure Regulation Of CAMP Metabolic Process Regulation Of Smooth Muscle Cell Proliferation Phospholipase D-activating G-protein Coupled Receptor Signaling Pathway Cellular Response To Sucrose Stimulus Protein Kinase C Deactivation Regulation Of Muscle Contraction Cellular Response To Mineralocorticoid Stimulus Response To Salt Rhythmic Excitation Regulation Of Blood Pressure Cellular Response To UV-A Nitric Oxide Transport Response To Prostaglandin F Positive Regulation Of Chemokine-mediated Signaling Pathway Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Vein Smooth Muscle Contraction Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Regulation Of Hormone Levels Regulation Of Systemic Arterial Blood Pressure By Endothelin Epithelial Fluid Transport Creatinine Metabolic Process Regulation Of Inflammatory Response Positive Regulation Of Sarcomere Organization Rhythmic Synaptic Transmission Response To UV-A Blood Circulation Response To Ozone Negative Regulation Of Smooth Muscle Cell Apoptotic Process Aging Angiogenesis Cellular Response To UV-B Artery Smooth Muscle Contraction Response To Muscle Stretch Tonic Smooth Muscle Contraction Maternal Process Involved In Parturition Positive Regulation Of Receptor Biosynthetic Process Positive Regulation Of Odontogenesis Angiotensin Maturation Cellular Response To Organic Substance Blood Vessel Morphogenesis Regulation Of Angiotensin Metabolic Process Complement Activation, Alternative Pathway Positive Regulation Of Renal Sodium Excretion Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Positive Regulation Of Prostaglandin Secretion
Tagcloud ?		7mg adriamycin cap cddp clinic cpm cr cyclophosphamide d1 d10 divided home hrs infusion nausea nephrotoxicities ns outpatient ovarian pr remarkably saline schedule schedules side sqm suitable twenty vomiting