H1F0 and KPNB1

Number of citations of the paper that reports this interaction (PMID 10228156)
70

Data Source:
HPRD (in vitro)

		H1F0	KPNB1
Gene Name		H1 histone family, member 0	karyopherin (importin) beta 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleosome Nuclear Chromatin Nucleus Nucleoplasm Nuclear Euchromatin Golgi Apparatus Actin Cytoskeleton	Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network
	Molecular Function	Protein Binding Chromatin DNA Binding Poly(A) RNA Binding	Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Ran GTPase Binding Protein Transporter Activity Enzyme Binding Protein Domain Specific Binding Poly(A) RNA Binding
	Biological Process	Apoptotic DNA Fragmentation Nucleosome Assembly Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis	Protein Import Into Nucleus, Translocation Apoptotic DNA Fragmentation Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Viral Process Viral Life Cycle Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Intracellular Transport Of Virus
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Activation of DNA fragmentation factor Apoptosis induced DNA fragmentation Cellular Senescence Programmed Cell Death Apoptotic execution phase	Metabolism of lipids and lipoproteins ISG15 antiviral mechanism Nuclear import of Rev protein HIV Infection Interferon Signaling Apoptotic execution phase Host Interactions of HIV factors Cytokine Signaling in Immune system Interactions of Rev with host cellular proteins Influenza Infection Antiviral mechanism by IFN-stimulated genes Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of DNA fragmentation factor Transport of Ribonucleoproteins into the Host Nucleus Apoptosis induced DNA fragmentation Programmed Cell Death
Drugs
Diseases
GWAS			Multiple sclerosis ( 22190364)
Protein-Protein Interactions		17 interactors: APP CCNE1 CDK1 CDK2 CDK4 CDK5 GRB2 IKBKG IPO5 IPO7 KPNA2 KPNB1 NEDD4L NOA1 PRKCB RAD51B XBP1	59 interactors: AMFR CD99 CHD3 CSE1L CSNK1A1 CUL4B ELAVL1 EXO1 FGFR1 H1F0 HIST1H1C IGFBP3 IGFBP5 IPO7 IPO8 KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 LYST MESDC2 MSL1 NFATC1 NFYA NUP153 NUP50 NUP54 NUP62 NUP98 NUTF2 PIAS4 PLCD1 PRKD3 PTHLH PTMA PTN PTPN2 RAN RANBP1 RANBP2 RCC1 RPL5 RUNX1T1 SMAD2 SMAD3 SMN1 SMNDC1 SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5 VIMP
Entrez ID		3005	3837
HPRD ID		00819	04114
Ensembl ID		ENSG00000189060
Uniprot IDs		P07305	B7Z752 B7ZAV6 Q14974
PDB IDs			1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW
Enriched GO Terms of Interacting Partners?		Viral Process NLS-bearing Protein Import Into Nucleus Response To Stress Response To Wounding Blood Coagulation Cellular Response To Stimulus Hemostasis Regulation Of Protein Kinase Activity Response To Stimulus Signaling Regulation Of Kinase Activity Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleocytoplasmic Transport Cell Communication Nuclear Transport Protein Import Into Nucleus Regulation Of Catalytic Activity Nuclear Import Regulation Of Phosphorylation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Response To Organic Substance Regulation Of Cell Cycle Regulation Of Body Fluid Levels Regulation Of Metabolic Process Wound Healing Apoptotic Process Signal Transduction Protein Import Regulation Of Phosphorus Metabolic Process Programmed Cell Death Histone Phosphorylation Positive Regulation Of Intracellular Protein Transport G1/S Transition Of Mitotic Cell Cycle Cell Death Death Protein Localization To Nucleus Regulation Of Protein Phosphorylation Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-threonine Phosphorylation Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cellular Process Cell Division Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Metabolic Process Regulation Of Nucleocytoplasmic Transport Ribosomal Protein Import Into Nucleus	Nucleocytoplasmic Transport Nuclear Transport Nuclear Import Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cytoplasmic Transport Protein Import Intracellular Transport Protein Localization Protein Transport Establishment Of Protein Localization Cellular Localization Establishment Of Localization In Cell Protein Localization To Organelle Protein Targeting Cellular Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Viral Life Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Nuclear Envelope Disassembly Cellular Nitrogen Compound Metabolic Process Nuclear Envelope Disassembly Gene Expression Cellular Response To Cytokine Stimulus Cell Cycle NLS-bearing Protein Import Into Nucleus Cell Cycle Process Viral Transcription Regulation Of Glucose Transport RNA Metabolic Process Cellular Response To Organic Substance Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Cytokine-mediated Signaling Pathway Response To Cytokine Cellular Response To Stimulus Nuclear Envelope Organization RNA Biosynthetic Process Mitotic Cell Cycle Glucose Transport Cellular Metabolic Process Hexose Transport Signal Transduction RNA Transport RNA Localization Response To Organic Substance
Tagcloud ?		2achist1h3 4achist1h4 blots diacetyl die disrupts dividing elongating histh3 histh4 killed maa meiosis methoxyacetic overrepresented pachytene pe postexposure prophase spermatids spermatocyte spermatocytes spermatogenesis spermatogonia testes testis tetraacetyl unexposed zero	30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste
Tagcloud (Difference) ?		2achist1h3 4achist1h4 blots diacetyl die disrupts dividing elongating histh3 histh4 killed maa meiosis methoxyacetic overrepresented pachytene pe postexposure prophase spermatids spermatocyte spermatocytes spermatogenesis spermatogonia testes testis tetraacetyl unexposed zero	30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste
Tagcloud (Intersection) ?