BLNK and CRKL

Number of citations of the paper that reports this interaction (PMID 11489945)
12

Data Source:
HPRD (in vivo)

		BLNK	CRKL
Gene Name		B-cell linker	v-crk avian sarcoma virus CT10 oncogene homolog-like
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol Plasma Membrane	Endosome Cytosol Extracellular Vesicular Exosome
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Inflammatory Response Humoral Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction B Cell Differentiation Intracellular Signal Transduction	Activation Of MAPKK Activity Blood Vessel Development JNK Cascade Ras Protein Signal Transduction Heart Development Organ Morphogenesis Anterior/posterior Pattern Specification Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Thymus Development Parathyroid Gland Development
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by Interleukins Regulation of signaling by CBL Cytokine Signaling in Immune system Interleukin-3, 5 and GM-CSF signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System	Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: BTK CBL CBLB CD72 CD79A CMTM3 CRKL ERBB2 GRAP2 GRB2 ITK LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1	71 interactors: ABL1 AOX1 ARHGAP32 ARHGEF5 BCAR1 BCR BIK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PTPN11 PXN RAPGEF1 RPL31 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TNS2 TYK2 WAC WAS WIPF1 YY1
Entrez ID		29760	1399
HPRD ID		05153	03596
Ensembl ID		ENSG00000095585	ENSG00000099942
Uniprot IDs		Q2MD54 Q2MD59 Q8WV28	P46109
PDB IDs			2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Antigen Receptor-mediated Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Cell Surface Receptor Signaling Pathway Cell Activation Immune Response Immune System Process Signal Transduction Regulation Of Lymphocyte Activation Signaling Cell Communication Regulation Of T Cell Activation Regulation Of Cell Activation Leukocyte Activation Defense Response B Cell Receptor Signaling Pathway Intracellular Signal Transduction T Cell Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Response To Stimulus Lymphocyte Activation Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Platelet Activation Positive Regulation Of Cell Adhesion Chemotaxis Wound Healing Positive Regulation Of T Cell Activation Locomotion Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Response To Stress	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Immune System Process Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Immune Response Defense Response Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Metabolic Process Cell Activation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Innate Immune Response Insulin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Locomotion Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Stress Phosphatidylinositol-mediated Signaling Response To Peptide Hormone Positive Regulation Of Phosphorylation Developmental Process
Tagcloud ?		bcr btk card11 cll connected crosstalk dlbcl dys emphasise encouraging fosfamatinib gab1 ibrutinib idelalisib integrins interconnected intimately leukaemia lymphocytic lymphomas lyn micrornas phosphatases physiology shp signalling syk tonic underscored	actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting
Tagcloud (Difference) ?		bcr btk card11 cll connected crosstalk dlbcl dys emphasise encouraging fosfamatinib gab1 ibrutinib idelalisib integrins interconnected intimately leukaemia lymphocytic lymphomas lyn micrornas phosphatases physiology shp syk tonic underscored	actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signals stimulating substrate transmitting
Tagcloud (Intersection) ?		signalling