CRKL and EVL

Number of citations of the paper that reports this interaction (PMID 10945997)
48

Data Source:
HPRD (in vitro)

		CRKL	EVL
Gene Name		v-crk avian sarcoma virus CT10 oncogene homolog-like	Enah/Vasp-like
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Cytosol Extracellular Vesicular Exosome	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium
	Molecular Function	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding Poly(A) RNA Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Activation Of MAPKK Activity Blood Vessel Development JNK Cascade Ras Protein Signal Transduction Heart Development Organ Morphogenesis Anterior/posterior Pattern Specification Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Thymus Development Parathyroid Gland Development	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly
Pathways		Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation	TCR signaling Generation of second messenger molecules Axon guidance Signaling by Robo receptor Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		71 interactors: ABL1 AOX1 ARHGAP32 ARHGEF5 BCAR1 BCR BIK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PTPN11 PXN RAPGEF1 RPL31 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TNS2 TYK2 WAC WAS WIPF1 YY1	27 interactors: ABI1 ABI3 ABL1 APBB1 APBB1IP CRKL DNMBP FYB FYN HCK HTT LYN PFN2 POT1 PRPF40A SEMA6A SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 WAS WASL XIRP1 ZDHHC17
Entrez ID		1399	51466
HPRD ID		03596	10942
Ensembl ID		ENSG00000099942	ENSG00000196405
Uniprot IDs		P46109	Q9UI08
PDB IDs		2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Immune System Process Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Immune Response Defense Response Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Metabolic Process Cell Activation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Innate Immune Response Insulin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Locomotion Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Stress Phosphatidylinositol-mediated Signaling Response To Peptide Hormone Positive Regulation Of Phosphorylation Developmental Process	Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Axon Guidance Phagocytosis Fc Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Immune Response-regulating Signaling Pathway Regulation Of Organelle Organization Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cellular Process Chemotaxis Cell Projection Morphogenesis Cytoskeleton Organization Cell Part Morphogenesis Neuron Projection Morphogenesis Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Neuron Development Locomotion Cell Morphogenesis Involved In Differentiation Regulation Of Cytoskeleton Organization Regulation Of Protein Complex Assembly Regulation Of Actin Cytoskeleton Organization Cell Morphogenesis Neuron Projection Development Regulation Of Vesicle-mediated Transport Neuron Differentiation Cell Development Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Cell Projection Organization Positive Regulation Of Organelle Organization Regulation Of Immune Response Actin Filament-based Process Negative Regulation Of Protein Complex Assembly Endocytosis Antigen Receptor-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Anatomical Structure Morphogenesis Regulation Of Immune System Process Actin Filament Organization Organelle Organization
Tagcloud ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 fbxw7 galns gnas iranian lgr mmp2 msi msp mss p2rx7 parsimony prkd1 ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22
Tagcloud (Difference) ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	adam29 cd109 cd248 cgh chl1 cladogram crcs csmd3 ercc6 ergic3 fbxw7 galns gnas iranian lgr mmp2 msi msp mss p2rx7 parsimony prkd1 ptprd rnf182 sfrs6 slc29a1 specifics syne1 tbx22
Tagcloud (Intersection) ?