CRKL and TGFB1I1

Number of citations of the paper that reports this interaction (PMID 9858471)
41

Data Source:
HPRD (in vitro)

		CRKL	TGFB1I1
Gene Name		v-crk avian sarcoma virus CT10 oncogene homolog-like	transforming growth factor beta 1 induced transcript 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Cytosol Extracellular Vesicular Exosome	Intracellular Cytoplasm Cytoskeleton Focal Adhesion Nuclear Matrix Extracellular Matrix
	Molecular Function	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding Poly(A) RNA Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Roundabout Binding Androgen Receptor Binding I-SMAD Binding
	Biological Process	Activation Of MAPKK Activity Blood Vessel Development JNK Cascade Ras Protein Signal Transduction Heart Development Organ Morphogenesis Anterior/posterior Pattern Specification Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Thymus Development Parathyroid Gland Development	Transcription From RNA Polymerase II Promoter Cell Adhesion Negative Regulation Of Cell Proliferation Response To Heat Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Morphogenesis Of Embryonic Epithelium Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Epithelial Cell Differentiation Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways		Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		71 interactors: ABL1 AOX1 ARHGAP32 ARHGEF5 BCAR1 BCR BIK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PTPN11 PXN RAPGEF1 RPL31 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TNS2 TYK2 WAC WAS WIPF1 YY1	29 interactors: AR CBLB CBLC CDKN2B CRKL CSK EP300 FKBP1A GIT1 GIT2 GP1BB HIPK3 HSPB1 ITGA4 MAPK15 NEDD4L NR3C1 PLA2G3 PTK2 PTK2B PTPN12 SDC4 SLC6A3 SMAD7 SVIL TGFBR2 TRAF4 UBQLN4 VCL
Entrez ID		1399	7041
HPRD ID		03596	03831
Ensembl ID		ENSG00000099942	ENSG00000140682
Uniprot IDs		P46109	O43294
PDB IDs		2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Immune System Process Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Immune Response Defense Response Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Metabolic Process Cell Activation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Innate Immune Response Insulin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Locomotion Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Stress Phosphatidylinositol-mediated Signaling Response To Peptide Hormone Positive Regulation Of Phosphorylation Developmental Process	Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Regulation Of Cellular Protein Metabolic Process Cell Activation Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Signaling Cell Communication Signal Transduction Response To Stimulus Regulation Of Catalytic Activity Transforming Growth Factor Beta Receptor Signaling Pathway Response To Organic Substance Organ Development Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Modification Process Cellular Response To Organic Substance Cellular Response To Transforming Growth Factor Beta Stimulus Cell Surface Receptor Signaling Pathway System Development Response To Transforming Growth Factor Beta Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Anatomical Structure Development Regulation Of Protein Catabolic Process Negative Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Negative Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Response To Growth Factor Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Phosphorylation Response To Organic Cyclic Compound Negative Regulation Of Signaling Cellular Response To Stimulus Multicellular Organismal Development Regulation Of Cellular Process Positive Regulation Of Protein Kinase Activity Developmental Process Positive Regulation Of Kinase Activity Negative Regulation Of Transferase Activity Positive Regulation Of Protein Phosphorylation
Tagcloud ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	aii aiii aiiis aiis astrocytoma astrocytomas beta1 bioinformatics biomarker contributing emt focused grade grades idh1 integration malignant microarrays multistep nbt progress progression qpcr shrna tp53 transcript transition validated
Tagcloud (Difference) ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	aii aiii aiiis aiis astrocytoma astrocytomas beta1 bioinformatics biomarker contributing emt grade grades idh1 integration malignant microarrays multistep nbt progress progression qpcr shrna tp53 transcript transition validated
Tagcloud (Intersection) ?		focused