BLNK and CMTM3

Number of citations of the paper that reports this interaction (PMID 15087455)
6

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		BLNK	CMTM3
Gene Name		B-cell linker	CKLF-like MARVEL transmembrane domain containing 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Cytosol Plasma Membrane	Extracellular Space Cytoplasm Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding	Cytokine Activity
	Biological Process	Inflammatory Response Humoral Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction B Cell Differentiation Intracellular Signal Transduction	Chemotaxis Positive Regulation Of B Cell Receptor Signaling Pathway
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by Interleukins Regulation of signaling by CBL Cytokine Signaling in Immune system Interleukin-3, 5 and GM-CSF signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: BTK CBL CBLB CD72 CD79A CMTM3 CRKL ERBB2 GRAP2 GRB2 ITK LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1	9 interactors: APP BLNK BTK MAPK1 MEST MOB1A MOB3C RABAC1 SPP1
Entrez ID		29760	123920
HPRD ID		05153	16259
Ensembl ID		ENSG00000095585	ENSG00000140931
Uniprot IDs		Q2MD54 Q2MD59 Q8WV28	Q96MX0
PDB IDs
Enriched GO Terms of Interacting Partners?		Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Antigen Receptor-mediated Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Innate Immune Response Cell Surface Receptor Signaling Pathway Cell Activation Immune Response Immune System Process Signal Transduction Regulation Of Lymphocyte Activation Signaling Cell Communication Regulation Of T Cell Activation Regulation Of Cell Activation Leukocyte Activation Defense Response B Cell Receptor Signaling Pathway Intracellular Signal Transduction T Cell Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Response To Stimulus Lymphocyte Activation Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Cell Activation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Signaling Platelet Activation Positive Regulation Of Cell Adhesion Chemotaxis Wound Healing Positive Regulation Of T Cell Activation Locomotion Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Response To Stress	Defense Response Cell Activation B Cell Receptor Signaling Pathway Immune System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Toll-like Receptor 4 Signaling Pathway Immune Response Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Regulation Of B Cell Cytokine Production Toll-like Receptor Signaling Pathway Anatomical Structure Development Chemotaxis Regulation Of Cell Differentiation MAPK Import Into Nucleus Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Molecule Of Fungal Origin Synaptic Growth At Neuromuscular Junction Response To Stimulus Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Antigen Receptor-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Innate Immune Response Mesoderm Development Cell Maturation Tissue Development Collateral Sprouting In Absence Of Injury Developmental Process B Cell Activation Negative Regulation Of Cell Differentiation Cell Differentiation Response To External Stimulus Response To Stress Intracellular Signal Transduction Response To Molecule Of Fungal Origin Regulation Of Golgi Inheritance Positive Regulation Of Innate Immune Response Innate Immune Response Negative Regulation Of Neuron Differentiation Platelet Activation Placenta Development Caveolin-mediated Endocytosis Collateral Sprouting Axon Midline Choice Point Recognition Cytosine Metabolic Process Response To Lipid
Tagcloud ?		bcr btk card11 cll connected crosstalk dlbcl dys emphasise encouraging fosfamatinib gab1 ibrutinib idelalisib integrins interconnected intimately leukaemia lymphocytic lymphomas lyn micrornas phosphatases physiology shp signalling syk tonic underscored	arrest carcinomas cleavage colony core cpg downregulated downregulation frequently g2 inducing largely located methylation p21 parp partially putative re remain responsive silenced sp1 sp3 suppressed suppressor testicular testis tissues
Tagcloud (Difference) ?		bcr btk card11 cll connected crosstalk dlbcl dys emphasise encouraging fosfamatinib gab1 ibrutinib idelalisib integrins interconnected intimately leukaemia lymphocytic lymphomas lyn micrornas phosphatases physiology shp signalling syk tonic underscored	arrest carcinomas cleavage colony core cpg downregulated downregulation frequently g2 inducing largely located methylation p21 parp partially putative re remain responsive silenced sp1 sp3 suppressed suppressor testicular testis tissues
Tagcloud (Intersection) ?