CRKL and CD34

Number of citations of the paper that reports this interaction (PMID 11389015)
7

Data Source:
HPRD (in vivo, in vitro)

		CRKL	CD34
Gene Name		v-crk avian sarcoma virus CT10 oncogene homolog-like	CD34 molecule
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Cytosol Extracellular Vesicular Exosome	Cytoplasm Lysosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Basal Plasma Membrane Apical Plasma Membrane Glomerular Endothelium Fenestra Intercellular Bridge Perinuclear Region Of Cytoplasm
	Molecular Function	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding Poly(A) RNA Binding	Transcription Factor Binding Carbohydrate Binding Sulfate Binding
	Biological Process	Activation Of MAPKK Activity Blood Vessel Development JNK Cascade Ras Protein Signal Transduction Heart Development Organ Morphogenesis Anterior/posterior Pattern Specification Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Thymus Development Parathyroid Gland Development	Tissue Homeostasis Endothelial Cell Proliferation Glomerular Filtration Endothelium Development Signal Transduction Regulation Of Blood Pressure Cell Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Single Organismal Cell-cell Adhesion Hemopoiesis Negative Regulation Of Blood Coagulation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Mesangial Cell-matrix Adhesion Paracrine Signaling Positive Regulation Of Odontogenesis Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Cell Motility Regulation Of Immune Response Leukocyte Migration Transdifferentiation Vascular Wound Healing Hematopoietic Stem Cell Proliferation Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granulocyte Colony-stimulating Factor Production Extracellular Vesicular Exosome Assembly Glomerular Endothelium Development Stem Cell Proliferation Metanephric Glomerular Mesangial Cell Differentiation Negative Regulation Of Cellular Response To Heat Negative Regulation Of Cellular Response To Hypoxia Negative Regulation Of Interleukin-2 Secretion Positive Regulation Of Glial Cell Line-derived Neurotrophic Factor Secretion Negative Regulation Of Neuron Death Positive Regulation Of Vasculogenesis
Pathways		Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23326517) Heart rate ( 23583979) Resting heart rate ( 20639392)
Protein-Protein Interactions		71 interactors: ABL1 AOX1 ARHGAP32 ARHGEF5 BCAR1 BCR BIK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PTPN11 PXN RAPGEF1 RPL31 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TNS2 TYK2 WAC WAS WIPF1 YY1	5 interactors: ATF5 CHST4 CREM CRKL PRKCD
Entrez ID		1399	947
HPRD ID		03596	00790
Ensembl ID		ENSG00000099942	ENSG00000174059
Uniprot IDs		P46109	B4DG27 P28906 Q5JTA5
PDB IDs		2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Immune System Process Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Immune Response Defense Response Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Metabolic Process Cell Activation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Innate Immune Response Insulin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Locomotion Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Stress Phosphatidylinositol-mediated Signaling Response To Peptide Hormone Positive Regulation Of Phosphorylation Developmental Process	Positive Regulation Of Phospholipid Scramblase Activity Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Circadian Rhythm Interleukin-10 Production Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Interleukin-12 Production Positive Regulation Of Ceramide Biosynthetic Process Olfactory Bulb Interneuron Development Regulation Of Ceramide Biosynthetic Process Rhythmic Process Positive Regulation Of Phospholipid Transport Negative Regulation Of Platelet Aggregation Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Metabolic Process Parathyroid Gland Development Protein Sulfation Positive Regulation Of Cellular Biosynthetic Process Olfactory Bulb Interneuron Differentiation Leukocyte Tethering Or Rolling Negative Regulation Of Astrocyte Differentiation Regulation Of Superoxide Anion Generation Regulation Of Platelet Aggregation Negative Regulation Of Platelet Activation Positive Regulation Of Protein Dephosphorylation Sulfation Neutrophil Activation Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress N-acetylglucosamine Metabolic Process Positive Regulation Of Lipid Catabolic Process Cellular Response To Growth Factor Stimulus Regulation Of Astrocyte Differentiation Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Cellular Extravasation Regulation Of Platelet Activation Cellular Senescence Regulation Of MAPK Cascade Immune System Process Negative Regulation Of Glial Cell Differentiation Forebrain Neuron Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Olfactory Bulb Development B Cell Proliferation
Tagcloud ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	agvhd alive allogeneic allografting allotransplantation anc ards august cgvhd donors evaluable february follows grades gvhd hematological leukaphereses mismatched mononucleated pbpc reach recipient scored september siblings sickle transplant unrelated unsupported
Tagcloud (Difference) ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	agvhd alive allogeneic allografting allotransplantation anc ards august cgvhd donors evaluable february follows grades gvhd hematological leukaphereses mismatched mononucleated pbpc reach recipient scored september siblings sickle transplant unrelated unsupported
Tagcloud (Intersection) ?