CRKL and BIK

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CRKL	BIK
Gene Name		v-crk avian sarcoma virus CT10 oncogene homolog-like	BCL2-interacting killer (apoptosis-inducing)
Image
Gene Ontology Annotations	Cellular Component	Endosome Cytosol Extracellular Vesicular Exosome	Endomembrane System Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding Poly(A) RNA Binding	Protein Binding Protein Heterodimerization Activity BH Domain Binding
	Biological Process	Activation Of MAPKK Activity Blood Vessel Development JNK Cascade Ras Protein Signal Transduction Heart Development Organ Morphogenesis Anterior/posterior Pattern Specification Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Thymus Development Parathyroid Gland Development	Apoptotic Process Spermatogenesis Male Gonad Development Apoptotic Mitochondrial Changes Positive Regulation Of Protein Homooligomerization Positive Regulation Of Release Of Cytochrome C From Mitochondria
Pathways		Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation
Drugs
Diseases
GWAS			Prostate cancer ( 21743057)
Protein-Protein Interactions		71 interactors: ABL1 AOX1 ARHGAP32 ARHGEF5 BCAR1 BCR BIK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PTPN11 PXN RAPGEF1 RPL31 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TNS2 TYK2 WAC WAS WIPF1 YY1	11 interactors: APP BCL2 BCL2A1 BCL2L1 BCL2L2 CRKL FATE1 MCL1 NR2F2 SOCS3 TANK
Entrez ID		1399	638
HPRD ID		03596	04547
Ensembl ID		ENSG00000099942	ENSG00000100290
Uniprot IDs		P46109	Q13323
PDB IDs		2BZX 2BZY 2DBK 2EO3 2LQN 2LQW	2IPE
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Immune System Process Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Immune Response Defense Response Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Metabolic Process Cell Activation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Innate Immune Response Insulin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Locomotion Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Stress Phosphatidylinositol-mediated Signaling Response To Peptide Hormone Positive Regulation Of Phosphorylation Developmental Process	Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Anoikis Intracellular Signal Transduction Apoptotic Signaling Pathway Response To Stress Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Signaling Negative Regulation Of Programmed Cell Death Cell Communication Apoptotic Process Reproductive Structure Development Negative Regulation Of Cell Death Reproductive System Development Intracellular Receptor Signaling Pathway Programmed Cell Death Regulation Of Intracellular Signal Transduction Cell Death Regulation Of Signal Transduction Neuron Apoptotic Process Death Negative Regulation Of Signal Transduction Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Death Negative Regulation Of Signaling Apoptotic Mitochondrial Changes Regulation Of Signaling Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Reproductive Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Developmental Process Involved In Reproduction Regulation Of Apoptotic Process Sexual Reproduction Innate Immune Response Cellular Response To Stress Cellular Response To DNA Damage Stimulus Regulation Of Cell Death Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Stimulus
Tagcloud ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	abt actinomycin antagonism antagonizing bak bcl bh3 carfilzomib concurrent crc cyclohexamide ectopic ectopically enabled irreversible isogenic kras mimetic noxa overcome potently sensitized sequestered shrna synergistic synergistically synergy ultimately xl
Tagcloud (Difference) ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	abt actinomycin antagonism antagonizing bak bcl bh3 carfilzomib concurrent crc cyclohexamide ectopic ectopically enabled irreversible isogenic kras mimetic noxa overcome potently sensitized sequestered shrna synergistic synergistically synergy ultimately xl
Tagcloud (Intersection) ?