CRKL and PPFIBP2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CRKL	PPFIBP2
Gene Name		v-crk avian sarcoma virus CT10 oncogene homolog-like	PTPRF interacting protein, binding protein 2 (liprin beta 2)
Image
Gene Ontology Annotations	Cellular Component	Endosome Cytosol Extracellular Vesicular Exosome	Extracellular Space Intracellular
	Molecular Function	Signal Transducer Activity SH3/SH2 Adaptor Activity Protein Binding Poly(A) RNA Binding	Molecular_function
	Biological Process	Activation Of MAPKK Activity Blood Vessel Development JNK Cascade Ras Protein Signal Transduction Heart Development Organ Morphogenesis Anterior/posterior Pattern Specification Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Thymus Development Parathyroid Gland Development
Pathways		Signaling by PDGF Signalling to ERKs Signalling by NGF Prolonged ERK activation events Signaling by Interleukins Downstream signal transduction Regulation of signaling by CBL Cytokine Signaling in Immune system NGF signalling via TRKA from the plasma membrane Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		71 interactors: ABL1 AOX1 ARHGAP32 ARHGEF5 BCAR1 BCR BIK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PTPN11 PXN RAPGEF1 RPL31 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TNS2 TYK2 WAC WAS WIPF1 YY1	10 interactors: APP CRK CRKL DTNB PPFIA1 PPFIA2 PPFIA3 PRNP PTPRC TSG101
Entrez ID		1399	8495
HPRD ID		03596	04391
Ensembl ID		ENSG00000099942	ENSG00000166387
Uniprot IDs		P46109	Q8ND30
PDB IDs		2BZX 2BZY 2DBK 2EO3 2LQN 2LQW	3QH9
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Signaling Regulation Of Signal Transduction Cell Communication Cellular Response To Stimulus Regulation Of Immune Response Regulation Of Signaling Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Immune System Process Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Response To Organic Substance Positive Regulation Of Intracellular Signal Transduction Cellular Response To Organonitrogen Compound Neurotrophin Signaling Pathway Immune Response Defense Response Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Metabolic Process Cell Activation Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Innate Immune Response Insulin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Movement Of Cell Or Subcellular Component Locomotion Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Wound Healing Response To Stress Phosphatidylinositol-mediated Signaling Response To Peptide Hormone Positive Regulation Of Phosphorylation Developmental Process	Glutamate Secretion Acid Secretion Dicarboxylic Acid Transport Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Regulation Of Protein Phosphorylation Cellular Copper Ion Homeostasis Secretion By Cell Establishment Of Localization In Cell Amino Acid Transport Neurotransmitter Transport Copper Ion Homeostasis Regulation Of Phosphorylation Secretion Cellular Localization Regulation Of Phosphorus Metabolic Process Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Regulation Of Kinase Activity Carboxylic Acid Transport Organic Acid Transport Regulation Of Cell Cycle Activation Of MAPKK Activity Regulation Of Signaling Axon Guidance Regulation Of Cellular Protein Metabolic Process Cellular Metal Ion Homeostasis Transport Organic Anion Transport Cellular Cation Homeostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Cellular Ion Homeostasis Positive Regulation Of Protein Kinase Activity Metal Ion Homeostasis Regulation Of Protein Metabolic Process Cell Adhesion Positive Regulation Of Kinase Activity Positive Regulation Of Protein Metabolic Process Immunoglobulin Biosynthetic Process Synaptic Growth At Neuromuscular Junction Positive Regulation Of Hematopoietic Stem Cell Migration Axonogenesis Cellular Chemical Homeostasis Signaling Positive Regulation Of Transferase Activity Ion Homeostasis Axon Development Cell Communication Collateral Sprouting In Absence Of Injury
Tagcloud ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs efemp2 endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Difference) ?		actions adaptor antiapoptotic behavior believed chemotactic converting crkii focused grb2 igfs implicated intracellularly ir irs mediates metabolism mitogenic nucleus occur organogenesis outlines promoting shc signalling signals stimulating substrate transmitting	acaa1 analogous ap1m2 aspirates cgn combat dcn ddr1 deadly ec ecs efemp2 endometrial eps8l2 fastkd1 gmip ikbke minimally noncarcinoma p2rx4 p4hb phkg2 ppp1r16a rassf7 rnf183 sirt6 socs2 tjp3 uterine
Tagcloud (Intersection) ?