GLS2 and SNTA1

Number of citations of the paper that reports this interaction (PMID 11163757)
12

Data Source:
HPRD (in vivo)

		GLS2	SNTA1
Gene Name		glutaminase 2 (liver, mitochondrial)	syntrophin, alpha 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Intracellular Cytoplasm Cytoskeleton Syntrophin Complex Lateral Plasma Membrane Cell Junction Neuromuscular Junction Sarcolemma Protein Complex Postsynaptic Membrane
	Molecular Function	Glutaminase Activity Protein Binding	Actin Binding Protein Binding Calmodulin Binding Sodium Channel Regulator Activity PDZ Domain Binding Ion Channel Binding Nitric-oxide Synthase Binding ATPase Binding
	Biological Process	Cellular Amino Acid Metabolic Process Glutamine Metabolic Process Synaptic Transmission Neurotransmitter Secretion Cellular Amino Acid Biosynthetic Process Glutamate Secretion Cellular Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Small Molecule Metabolic Process Reactive Oxygen Species Metabolic Process	Regulation Of Heart Rate Regulation Of Vasoconstriction By Circulating Norepinephrine Muscle Contraction Neuromuscular Junction Development Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Sodium Ion Transmembrane Transport
Pathways		Neurotransmitter Release Cycle Amino acid synthesis and interconversion (transamination) Glutamate Neurotransmitter Release Cycle Metabolism of amino acids and derivatives Transmission across Chemical Synapses
Drugs		L-Glutamic Acid
Diseases
GWAS		Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037)
Protein-Protein Interactions		11 interactors: CASK DLG1 DLG2 DLG3 DLG4 GRHPR INADL PAG1 RGS3 SNTA1 TAX1BP3	72 interactors: ABCA1 ABCC4 ACTA2 ADAMTS6 ADH5 ADRA1D ADRA2A ADRB1 AGTR2 ATP2B2 ATP6V0B BAI1 BAI2 BAI3 C3AR1 CALM1 CD3E CNKSR2 COPB1 DGKZ DMD DTNA F8A1 FABP1 FAM189B GDA GLS GLS2 GOLGA2 GRB2 GUCY1A2 HTR2B HTR2C IL2RA IL9 ITGB5 KCNA4 KCNA5 KCNJ10 KCNJ12 KCNJ15 KCNJ4 KIF1B LMO1 MAP4 MAPK12 MAS1 MAST1 MCM7 MED8 MTMR2 NAT1 NMU NOS1 PFN2 PRLHR PSKH1 SCN1A SCN4A SCN5A SCTR SLC16A7 SLC1A7 SLC2A3 SLC6A3 SSTR1 TGFA TLX3 TRA TRBV12-3 UTRN XRCC6
Entrez ID		27165	6640
HPRD ID		05901	03009
Ensembl ID		ENSG00000135423	ENSG00000101400
Uniprot IDs		Q9UI32	B4DX40 Q13424
PDB IDs		4BQM
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Membrane Regulation Of Ion Transmembrane Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Organophosphate Metabolic Process Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Cortical Cytoskeleton Organization Negative Regulation Of Cell Adhesion Synaptic Transmission Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Negative Regulation Of Cell Proliferation Regulation Of Membrane Potential Tight Junction Assembly Small Molecule Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Phosphatase Activity Regulation Of Sodium Ion Transport Membrane Organization Negative Regulation Of Dephosphorylation Regulation Of Vasoconstriction By Circulating Norepinephrine Apical Junction Assembly Cell-cell Signaling Axon Guidance Negative Regulation Of T Cell Activation Phosphorylation Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Phosphatase Activity Negative Regulation Of Homotypic Cell-cell Adhesion Cell-cell Junction Assembly Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cellular Metabolic Process Axonogenesis Regulation Of Dephosphorylation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Peptidyl-cysteine S-nitrosylation T Cell Cytokine Production Negative Regulation Of Leukocyte Activation Chemotaxis Regulation Of Cell Adhesion	Cell-cell Signaling Synaptic Transmission Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Ion Transport Muscle System Process Muscle Contraction Regulation Of Heart Contraction G-protein Coupled Receptor Signaling Pathway Metal Ion Transport Ion Transport Regulation Of Muscle Contraction Blood Circulation Negative Regulation Of Adrenergic Receptor Signaling Pathway Monovalent Inorganic Cation Transport Regulation Of Sodium Ion Transmembrane Transport Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Cation Transport Regulation Of Striated Muscle Contraction Cell Surface Receptor Signaling Pathway Cation Transmembrane Transport Transmembrane Transport Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Homeostasis Positive Regulation Of Cell Proliferation Ion Transmembrane Transport Potassium Ion Import Regulation Of Phosphorus Metabolic Process Behavior Response To Stimulus Regulation Of Membrane Potential Positive Regulation Of Transport Regulation Of Cellular Process Regulation Of Sodium Ion Transport CGMP Metabolic Process Positive Regulation Of Ion Transport Response To Drug Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Cyclic Nucleotide Metabolic Process Action Potential Regulation Of Body Fluid Levels Multicellular Organismal Response To Stress Response To Stress Cellular Response To Stimulus
Tagcloud ?		alkylating ammonia antiproliferative codes dominate ectopic ga gab gac gbm glioblastoma glioblastomas gliomas gln glu glutaminase glutamine isoforms kga lga metabolizes neoplastic pivotal quiescent sensitized strengthen t98g traces	acquisition assays depletion displacement downregulate e3b1 effectively emphasise eps8 explored forming generation grb2 healing immunoprecipitation involving malignancy migration migratory overexpressed p66shc predominantly rac1 ros shrnas sirnas sos1 syntrophin wound
Tagcloud (Difference) ?		alkylating ammonia antiproliferative codes dominate ectopic ga gab gac gbm glioblastoma glioblastomas gliomas gln glu glutaminase glutamine isoforms kga lga metabolizes neoplastic pivotal quiescent sensitized strengthen t98g traces	acquisition assays depletion displacement downregulate e3b1 effectively emphasise eps8 explored forming generation grb2 healing immunoprecipitation involving malignancy migration migratory overexpressed p66shc predominantly rac1 ros shrnas sirnas sos1 syntrophin wound
Tagcloud (Intersection) ?