GLS2 and RGS3

Number of citations of the paper that reports this interaction (PMID 16637659)
18

Data Source:
HPRD (in vitro)

		GLS2	RGS3
Gene Name		glutaminase 2 (liver, mitochondrial)	regulator of G-protein signaling 3
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Glutaminase Activity Protein Binding	GTPase Activator Activity
	Biological Process	Cellular Amino Acid Metabolic Process Glutamine Metabolic Process Synaptic Transmission Neurotransmitter Secretion Cellular Amino Acid Biosynthetic Process Glutamate Secretion Cellular Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Small Molecule Metabolic Process Reactive Oxygen Species Metabolic Process	Inactivation Of MAPK Activity Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity
Pathways		Neurotransmitter Release Cycle Amino acid synthesis and interconversion (transamination) Glutamate Neurotransmitter Release Cycle Metabolism of amino acids and derivatives Transmission across Chemical Synapses
Drugs		L-Glutamic Acid
Diseases
GWAS		Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037)
Protein-Protein Interactions		11 interactors: CASK DLG1 DLG2 DLG3 DLG4 GRHPR INADL PAG1 RGS3 SNTA1 TAX1BP3	22 interactors: ACD APP CNKSR2 EFNB1 EFNB2 ESR1 GLS2 GNA11 GNAI3 GORASP2 GRIN2A HES4 HIPK3 MAPK12 PARK2 PAX6 PLSCR1 SCN5A YWHAB YWHAE YWHAQ YWHAZ
Entrez ID		27165	5998
HPRD ID		05901	03720
Ensembl ID		ENSG00000135423	ENSG00000138835
Uniprot IDs		Q9UI32	B3KUB2 B3KVT7 B3KWG8 H7BXY1 P49796 Q53GP3 Q8NFN6
PDB IDs		4BQM	2F5Y 2OJ4 3FBK
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Membrane Regulation Of Ion Transmembrane Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Organophosphate Metabolic Process Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Cortical Cytoskeleton Organization Negative Regulation Of Cell Adhesion Synaptic Transmission Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Negative Regulation Of Cell Proliferation Regulation Of Membrane Potential Tight Junction Assembly Small Molecule Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Phosphatase Activity Regulation Of Sodium Ion Transport Membrane Organization Negative Regulation Of Dephosphorylation Regulation Of Vasoconstriction By Circulating Norepinephrine Apical Junction Assembly Cell-cell Signaling Axon Guidance Negative Regulation Of T Cell Activation Phosphorylation Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Phosphatase Activity Negative Regulation Of Homotypic Cell-cell Adhesion Cell-cell Junction Assembly Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cellular Metabolic Process Axonogenesis Regulation Of Dephosphorylation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Peptidyl-cysteine S-nitrosylation T Cell Cytokine Production Negative Regulation Of Leukocyte Activation Chemotaxis Regulation Of Cell Adhesion	Positive Regulation Of Mitochondrion Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway System Development Platelet Activation Cell-cell Signaling Positive Regulation Of Apoptotic Signaling Pathway Axon Guidance Multicellular Organismal Development Signaling Nervous System Development Anatomical Structure Development Cell Communication Response To Wounding Regulation Of Apoptotic Process Regulation Of Signaling Regulation Of Cell Death Regulation Of Cellular Process Axonogenesis Developmental Process Locomotion Axon Development Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Response To Stress Positive Regulation Of Programmed Cell Death Chemotaxis Cellular Response To Stimulus Positive Regulation Of Cell Death Response To External Stimulus Apoptotic Process Neuron Projection Morphogenesis Regulation Of Catalytic Activity Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Organelle Organization Cell Death Death Cell Surface Receptor Signaling Pathway Blood Coagulation Cell Morphogenesis Involved In Differentiation Hemostasis Positive Regulation Of Transport Response To Stimulus Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Intracellular Transport
Tagcloud ?		alkylating ammonia antiproliferative codes dominate ectopic ga gab gac gbm glioblastoma glioblastomas gliomas gln glu glutaminase glutamine isoforms kga lga metabolizes neoplastic pivotal quiescent sensitized strengthen t98g traces
Tagcloud (Difference) ?		alkylating ammonia antiproliferative codes dominate ectopic ga gab gac gbm glioblastoma glioblastomas gliomas gln glu glutaminase glutamine isoforms kga lga metabolizes neoplastic pivotal quiescent sensitized strengthen t98g traces
Tagcloud (Intersection) ?