GLS2 and DLG4

Number of citations of the paper that reports this interaction (PMID 16637659)
18

Data Source:
HPRD (in vitro)

		GLS2	DLG4
Gene Name		glutaminase 2 (liver, mitochondrial)	discs, large homolog 4 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Cytoplasm Endoplasmic Reticulum Plasma Membrane Synaptic Vesicle Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Basolateral Plasma Membrane Cell Junction Endocytic Vesicle Membrane Cortical Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Selective Glutamate Receptor Complex Dendrite Cytoplasm Dendritic Spine Juxtaparanode Region Of Axon Cerebellar Mossy Fiber Neuron Projection Terminus Neuron Spine Synapse Postsynaptic Membrane Excitatory Synapse Neuronal Postsynaptic Density
	Molecular Function	Glutaminase Activity Protein Binding	Guanylate Kinase Activity Protein Binding Protein C-terminus Binding Protein Phosphatase Binding PDZ Domain Binding Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding P2Y1 Nucleotide Receptor Binding Protein Complex Binding Acetylcholine Receptor Binding Ionotropic Glutamate Receptor Binding Scaffold Protein Binding
	Biological Process	Cellular Amino Acid Metabolic Process Glutamine Metabolic Process Synaptic Transmission Neurotransmitter Secretion Cellular Amino Acid Biosynthetic Process Glutamate Secretion Cellular Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Small Molecule Metabolic Process Reactive Oxygen Species Metabolic Process	Negative Regulation Of Receptor Internalization Protein Complex Assembly Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Nervous System Development Axon Guidance Learning Synaptic Vesicle Maturation Social Behavior Protein Localization To Synapse Locomotory Exploration Behavior Establishment Of Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Synaptic Transmission Neuromuscular Process Controlling Balance Dendritic Spine Morphogenesis Vocalization Behavior Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Receptor Localization To Synapse Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Grooming Behavior
Pathways		Neurotransmitter Release Cycle Amino acid synthesis and interconversion (transamination) Glutamate Neurotransmitter Release Cycle Metabolism of amino acids and derivatives Transmission across Chemical Synapses	Axon guidance L1CAM interactions Activation of Kainate Receptors upon glutamate binding CREB phosphorylation through the activation of Ras Trafficking of AMPA receptors Activation of NMDA receptor upon glutamate binding and postsynaptic events CREB phosphorylation through the activation of CaMKII NrCAM interactions Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Activation of Ca-permeable Kainate Receptor Unblocking of NMDA receptor, glutamate binding and activation Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Ras activation uopn Ca2+ infux through NMDA receptor Post NMDA receptor activation events Transmission across Chemical Synapses
Drugs		L-Glutamic Acid
Diseases
GWAS		Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037)	Liver enzyme levels (alkaline phosphatase) ( 22001757)
Protein-Protein Interactions		11 interactors: CASK DLG1 DLG2 DLG3 DLG4 GRHPR INADL PAG1 RGS3 SNTA1 TAX1BP3	104 interactors: ACTN2 ADRB1 AKAP5 ARHGAP32 ASIC3 ATP2B2 ATP2B4 BAI1 BEGAIN CACNG2 CASK CD46 CIT CNKSR2 CRIPT DLG2 DLG3 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DYNLL1 EFNB2 ERBB2 ERBB2IP ERBB4 EXOC4 FYN FZD1 FZD2 FZD4 FZD7 GDA GLS2 GNG13 GRASP GRIK1 GRIK2 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GUCY1A2 HGS HTR2A HTR2C HTT IL13RA1 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCND2 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF13B KIF1B LIN7A LIN7B LPHN1 LRFN1 LRP1 LRP2 LRP8 LRRC1 LYN MAP1A MAP3K10 MAPK12 MDM2 NCKIPSD NDOR1 NLGN1 NLGN2 NLGN3 NLGN4X NOS1 PCDH10 PRKCA PTK2B PTPRG SCN5A SEMA4B SEMA4C SEMA4F SEMA4G SHANK1 SHANK2 SIPA1L1 SPRR2A SRC SYNGAP1 TANC1 WNT3A YES1 ZDHHC17
Entrez ID		27165	1742
HPRD ID		05901	04199
Ensembl ID		ENSG00000135423	ENSG00000132535
Uniprot IDs		Q9UI32	B7Z647 B9EGL1 P78352
PDB IDs		4BQM	1KEF 3I4W 3K82 3ZRT
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Membrane Regulation Of Ion Transmembrane Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Organophosphate Metabolic Process Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Cortical Cytoskeleton Organization Negative Regulation Of Cell Adhesion Synaptic Transmission Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Negative Regulation Of Cell Proliferation Regulation Of Membrane Potential Tight Junction Assembly Small Molecule Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Phosphatase Activity Regulation Of Sodium Ion Transport Membrane Organization Negative Regulation Of Dephosphorylation Regulation Of Vasoconstriction By Circulating Norepinephrine Apical Junction Assembly Cell-cell Signaling Axon Guidance Negative Regulation Of T Cell Activation Phosphorylation Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Phosphatase Activity Negative Regulation Of Homotypic Cell-cell Adhesion Cell-cell Junction Assembly Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cellular Metabolic Process Axonogenesis Regulation Of Dephosphorylation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Peptidyl-cysteine S-nitrosylation T Cell Cytokine Production Negative Regulation Of Leukocyte Activation Chemotaxis Regulation Of Cell Adhesion	Cell-cell Signaling Synaptic Transmission Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Ion Transmembrane Transport Membrane Depolarization Nervous System Development Regulation Of Postsynaptic Membrane Potential Regulation Of Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Neurological System Process Neuron-neuron Synaptic Transmission Glutamate Receptor Signaling Pathway Signal Transduction Metal Ion Transport Synaptic Transmission, Glutamatergic Neurogenesis Response To Stimulus Ion Transport Generation Of Neurons Cellular Response To Stimulus Transport System Development Cation Transport Cell Surface Receptor Signaling Pathway Single-organism Behavior Sensory Perception Of Pain Behavior Neuron Differentiation Regulation Of Signal Transduction Response To Abiotic Stimulus Ion Transmembrane Transport Regulation Of Cellular Localization Anatomical Structure Development Regulation Of Cellular Process Membrane Hyperpolarization Cell Differentiation Cation Transmembrane Transport Multicellular Organismal Development Developmental Process Regulation Of Phosphorus Metabolic Process Learning Response To External Stimulus Cellular Process Neuron Development Positive Regulation Of Signal Transduction
Tagcloud ?		alkylating ammonia antiproliferative codes dominate ectopic ga gab gac gbm glioblastoma glioblastomas gliomas gln glu glutaminase glutamine isoforms kga lga metabolizes neoplastic pivotal quiescent sensitized strengthen t98g traces	6g1 alleviated amyloid ca1 counteract densities distant fibrillar immunohistochemically immunotherapy oligomer oligomeric oligomers plaque plaques presynapses psd95 quantified reservoirs sequestering suffices synapse synapses synapsin synaptotoxic tg2576 unchanged unspecific vicinity
Tagcloud (Difference) ?		alkylating ammonia antiproliferative codes dominate ectopic ga gab gac gbm glioblastoma glioblastomas gliomas gln glu glutaminase glutamine isoforms kga lga metabolizes neoplastic pivotal quiescent sensitized strengthen t98g traces	6g1 alleviated amyloid ca1 counteract densities distant fibrillar immunohistochemically immunotherapy oligomer oligomeric oligomers plaque plaques presynapses psd95 quantified reservoirs sequestering suffices synapse synapses synapsin synaptotoxic tg2576 unchanged unspecific vicinity
Tagcloud (Intersection) ?