GLS2 and DLG2

Number of citations of the paper that reports this interaction (PMID 16637659)
18

Data Source:
HPRD (in vitro)

		GLS2	DLG2
Gene Name		glutaminase 2 (liver, mitochondrial)	discs, large homolog 2 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Plasma Membrane Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Juxtaparanode Region Of Axon Postsynaptic Membrane
	Molecular Function	Glutaminase Activity Protein Binding	Guanylate Kinase Activity Protein Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Cellular Amino Acid Metabolic Process Glutamine Metabolic Process Synaptic Transmission Neurotransmitter Secretion Cellular Amino Acid Biosynthetic Process Glutamate Secretion Cellular Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Small Molecule Metabolic Process Reactive Oxygen Species Metabolic Process	Synaptic Transmission Nervous System Development Negative Regulation Of Phosphatase Activity Sensory Perception Of Pain Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Nucleotide Phosphorylation Receptor Localization To Synapse
Pathways		Neurotransmitter Release Cycle Amino acid synthesis and interconversion (transamination) Glutamate Neurotransmitter Release Cycle Metabolism of amino acids and derivatives Transmission across Chemical Synapses
Drugs		L-Glutamic Acid
Diseases
GWAS		Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037)	Obesity-related traits ( 23251661) Parkinson's disease ( 17052657) Phospholipid levels (plasma) ( 22359512) Protein quantitative trait loci ( 18464913) Wilms tumor ( 22544364)
Protein-Protein Interactions		11 interactors: CASK DLG1 DLG2 DLG3 DLG4 GRHPR INADL PAG1 RGS3 SNTA1 TAX1BP3	40 interactors: ABCA1 ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 ERBB4 FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 SCN4A SCN5A SEMA4C WNT3A
Entrez ID		27165	1740
HPRD ID		05901	04663
Ensembl ID		ENSG00000135423	ENSG00000150672
Uniprot IDs		Q9UI32	B7Z2T4 E9PN83 Q15700
PDB IDs		4BQM	2BYG 2HE2
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Membrane Regulation Of Ion Transmembrane Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Organophosphate Metabolic Process Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Cortical Cytoskeleton Organization Negative Regulation Of Cell Adhesion Synaptic Transmission Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Negative Regulation Of Cell Proliferation Regulation Of Membrane Potential Tight Junction Assembly Small Molecule Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Phosphatase Activity Regulation Of Sodium Ion Transport Membrane Organization Negative Regulation Of Dephosphorylation Regulation Of Vasoconstriction By Circulating Norepinephrine Apical Junction Assembly Cell-cell Signaling Axon Guidance Negative Regulation Of T Cell Activation Phosphorylation Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Phosphatase Activity Negative Regulation Of Homotypic Cell-cell Adhesion Cell-cell Junction Assembly Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cellular Metabolic Process Axonogenesis Regulation Of Dephosphorylation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Peptidyl-cysteine S-nitrosylation T Cell Cytokine Production Negative Regulation Of Leukocyte Activation Chemotaxis Regulation Of Cell Adhesion	Cell-cell Signaling Synaptic Transmission Membrane Depolarization Regulation Of Ion Transmembrane Transport Signaling Cell Communication Regulation Of Membrane Potential Regulation Of Ion Transport Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Neuron-neuron Synaptic Transmission Neuromuscular Process Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Ion Transmembrane Transport Neurological System Process Regulation Of Signaling Glutamate Receptor Signaling Pathway Startle Response Ion Transport Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Signal Transduction Negative Regulation Of Adrenergic Receptor Signaling Pathway Involved In Heart Process Regulation Of Sodium Ion Transmembrane Transport Nervous System Development Metal Ion Transport Transmembrane Transport Positive Regulation Of Membrane Potential Transport Negative Regulation Of Adrenergic Receptor Signaling Pathway Neuron Differentiation Cation Transmembrane Transport Protein Localization To Synapse Positive Regulation Of Transport Neurogenesis Behavior Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Regulation Of Receptor Activity Metencephalon Development Regulation Of Respiratory Gaseous Exchange Regulation Of Cellular Process Regulation Of Sodium Ion Transport Generation Of Neurons Postsynaptic Membrane Organization Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cell Morphogenesis Involved In Differentiation Postsynaptic Membrane Assembly
Tagcloud ?		alkylating ammonia antiproliferative codes dominate ectopic ga gab gac gbm glioblastoma glioblastomas gliomas gln glu glutaminase glutamine isoforms kga lga metabolizes neoplastic pivotal quiescent sensitized strengthen t98g traces	17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member neoplastic oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Difference) ?		alkylating ammonia antiproliferative codes dominate ectopic ga gab gac gbm glioblastoma glioblastomas gliomas gln glu glutaminase glutamine isoforms kga lga metabolizes pivotal quiescent sensitized strengthen t98g traces	17q12 apical basolateral defining disc discs dlg3 encodes germline guanylate homology identity imaginal lethal mediating member oncogene organization originally overgrowth p55 phosphoprotein polarity q21 recessive segment similarity
Tagcloud (Intersection) ?		neoplastic