GLS2

Gene Name		glutaminase 2 (liver, mitochondrial)
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Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Glutaminase Activity Protein Binding
	Biological Process	Cellular Amino Acid Metabolic Process Glutamine Metabolic Process Synaptic Transmission Neurotransmitter Secretion Cellular Amino Acid Biosynthetic Process Glutamate Secretion Cellular Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Small Molecule Metabolic Process Reactive Oxygen Species Metabolic Process
Pathways		Neurotransmitter Release Cycle Amino acid synthesis and interconversion (transamination) Glutamate Neurotransmitter Release Cycle Metabolism of amino acids and derivatives Transmission across Chemical Synapses
Drugs		L-Glutamic Acid
Diseases
GWAS		Metabolic traits ( 21886157) Metabolite levels ( 22286219 22916037)
Protein-protein Interactions		11 interactors: CASK DLG1 DLG2 DLG3 DLG4 GRHPR INADL PAG1 RGS3 SNTA1 TAX1BP3
Entrez ID		27165
HPRD ID		05901
Ensembl ID		ENSG00000135423
Uniprot IDs		Q9UI32
PDB IDs		4BQM
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Nucleotide Phosphorylation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Nucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Membrane Regulation Of Ion Transmembrane Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Organophosphate Metabolic Process Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Cortical Cytoskeleton Organization Negative Regulation Of Cell Adhesion Synaptic Transmission Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transport Negative Regulation Of Cell Proliferation Regulation Of Membrane Potential Tight Junction Assembly Small Molecule Metabolic Process Regulation Of Catalytic Activity Negative Regulation Of Phosphatase Activity Regulation Of Sodium Ion Transport Membrane Organization Negative Regulation Of Dephosphorylation Regulation Of Vasoconstriction By Circulating Norepinephrine Apical Junction Assembly Cell-cell Signaling Axon Guidance Negative Regulation Of T Cell Activation Phosphorylation Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Phosphatase Activity Negative Regulation Of Homotypic Cell-cell Adhesion Cell-cell Junction Assembly Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cellular Metabolic Process Axonogenesis Regulation Of Dephosphorylation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Axon Development Cell Morphogenesis Involved In Neuron Differentiation Negative Regulation Of Peptidyl-cysteine S-nitrosylation T Cell Cytokine Production Negative Regulation Of Leukocyte Activation Chemotaxis Regulation Of Cell Adhesion
Tagcloud ?		alkylating ammonia antiproliferative codes dominate ectopic ga gab gac gbm glioblastoma glioblastomas gliomas gln glu glutaminase glutamine isoforms kga lga metabolizes neoplastic pivotal quiescent sensitized strengthen t98g traces