FANCD2 and MRE11A

Number of citations of the paper that reports this interaction (PMID 12447395)
54

Data Source:
HPRD (in vivo)

		FANCD2	MRE11A
Gene Name		Fanconi anemia, complementation group D2	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Condensed Chromosome Nucleoplasm Golgi Apparatus Intracellular Membrane-bounded Organelle	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytosol Mre11 Complex Site Of Double-strand Break
	Molecular Function	Protein Binding DNA Polymerase Binding	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Double-stranded DNA Binding ATP-dependent DNA Helicase Activity Nuclease Activity Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding 3'-5' Exonuclease Activity Manganese Ion Binding
	Biological Process	DNA Repair Synapsis Gamete Generation Response To Gamma Radiation	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair Base-excision Repair Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Sister Chromatid Cohesion Mitotic G2 DNA Damage Checkpoint Synapsis Reciprocal Meiotic Recombination Cell Proliferation Intra-S DNA Damage Checkpoint Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Negative Regulation Of DNA Endoreduplication Positive Regulation Of Kinase Activity Innate Immune Response Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Fanconi Anemia pathway Regulation of the Fanconi anemia pathway	Meiotic recombination DNA Damage/Telomere Stress Induced Senescence MRN complex relocalizes to nuclear foci Cytosolic sensors of pathogen-associated DNA Cellular Senescence Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks Homologous Recombination Repair STING mediated induction of host immune responses Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair IRF3-mediated induction of type I IFN Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ATM ATR BLM BRCA1 BRCA2 FANCC FANCE FANCI FANCL MEN1 MRE11A NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB USP1	16 interactors: ATM ATR BRCA1 CCNE1 DCLRE1C EP300 FANCD2 H2AFX LIG1 NBN NEK1 PRKDC RAD50 RBBP8 RECQL5 XRCC6
Entrez ID		2177	4361
HPRD ID		01968	02889
Ensembl ID		ENSG00000144554	ENSG00000020922
Uniprot IDs		Q9BXW9	B3KTC7 P49959 Q05D78
PDB IDs			3T1I
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Regulation Of DNA Replication Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cell Cycle DNA Recombination Cell Cycle Process Response To Stress Double-strand Break Repair Negative Regulation Of DNA Replication Cell Cycle Checkpoint Response To Ionizing Radiation DNA Damage Checkpoint Telomere Maintenance DNA Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process G2 DNA Damage Checkpoint Negative Regulation Of DNA Metabolic Process Regulation Of Cellular Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stimulus Nitrogen Compound Metabolic Process Response To Stimulus Mitotic G2 DNA Damage Checkpoint Regulation Of Protein Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Checkpoint Response To Abiotic Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Cellular Metabolic Process Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Negative Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Process Chromosome Organization Regulation Of Response To DNA Damage Stimulus Mitotic Cell Cycle	DNA Recombination Double-strand Break Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair Via Homologous Recombination DNA Repair Recombinational Repair Cell Cycle Process DNA Metabolic Process Cellular Response To Stress Response To Ionizing Radiation Cell Cycle Telomere Maintenance Organelle Organization Response To Radiation Chromosome Organization DNA Damage Checkpoint Response To Stress Cell Cycle Checkpoint Response To Abiotic Stimulus Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process V(D)J Recombination Cellular Response To Stimulus Meiotic Cell Cycle Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process G2 DNA Damage Checkpoint DNA Replication Response To Gamma Radiation Response To Stimulus Positive Regulation Of Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Nonhomologous End Joining Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage DNA Conformation Change Signal Transduction By P53 Class Mediator Regulation Of Cellular Response To Heat Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Response To DNA Damage Stimulus Apoptotic Signaling Pathway Reproduction B Cell Activation Regulation Of Protein Metabolic Process
Tagcloud ?		10ng agreed atr bard1 belonged biosynthetic biphenyls brca2 dioxin figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating	5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt nbn nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald
Tagcloud (Difference) ?		10ng agreed bard1 belonged biosynthetic biphenyls brca2 dioxin figf hands immunoblots impulses kcnma1 lactational mycn ndl neurobiological npy4r ontology operator6 pcbs performances projection rad51 scn1a summation transcriptomic validating	5yrs atm brfr category cohorts ddr decisions fail gains gleason guided igrt nbn nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald
Tagcloud (Intersection) ?		atr