MRE11A and LIG1

Number of citations of the paper that reports this interaction (PMID 8530104)
32

Data Source:
HPRD (two hybrid)

		MRE11A	LIG1
Gene Name		MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	ligase I, DNA, ATP-dependent
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytosol Mre11 Complex Site Of Double-strand Break	Nucleus Nucleoplasm Chromosome Mitochondrion Golgi Apparatus Intracellular Membrane-bounded Organelle
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Double-stranded DNA Binding ATP-dependent DNA Helicase Activity Nuclease Activity Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding 3'-5' Exonuclease Activity Manganese Ion Binding	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity ATP Binding Metal Ion Binding
	Biological Process	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair Base-excision Repair Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Sister Chromatid Cohesion Mitotic G2 DNA Damage Checkpoint Synapsis Reciprocal Meiotic Recombination Cell Proliferation Intra-S DNA Damage Checkpoint Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Negative Regulation Of DNA Endoreduplication Positive Regulation Of Kinase Activity Innate Immune Response Nucleic Acid Phosphodiester Bond Hydrolysis	Mitotic Cell Cycle Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Strand Elongation Involved In DNA Replication Lagging Strand Elongation DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Anatomical Structure Morphogenesis Telomere Maintenance Via Semi-conservative Replication V(D)J Recombination Response To Hydrogen Peroxide DNA Ligation Involved In DNA Repair Cell Division DNA Biosynthetic Process
Pathways		Meiotic recombination DNA Damage/Telomere Stress Induced Senescence MRN complex relocalizes to nuclear foci Cytosolic sensors of pathogen-associated DNA Cellular Senescence Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks Homologous Recombination Repair STING mediated induction of host immune responses Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair IRF3-mediated induction of type I IFN Innate Immune System	Nucleotide Excision Repair Gap-filling DNA repair synthesis and ligation in TC-NER Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) DNA strand elongation Mismatch Repair Telomere Maintenance Removal of DNA patch containing abasic residue Homologous recombination repair of replication-independent double-strand breaks Double-Strand Break Repair Resolution of D-loop structures through Holliday junction intermediates Resolution of Abasic Sites (AP sites) Base Excision Repair Resolution of D-loop structures Synthesis of DNA Chromosome Maintenance Lagging Strand Synthesis Processive synthesis on the lagging strand Processive synthesis on the C-strand of the telomere S Phase Telomere C-strand (Lagging Strand) Synthesis Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Global Genomic NER (GG-NER) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Resolution of AP sites via the multiple-nucleotide patch replacement pathway Transcription-coupled NER (TC-NER) Homologous Recombination Repair
Drugs			Bleomycin
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ATM ATR BRCA1 CCNE1 DCLRE1C EP300 FANCD2 H2AFX LIG1 NBN NEK1 PRKDC RAD50 RBBP8 RECQL5 XRCC6	6 interactors: CSNK2A1 INPP1 MRE11A PCNA RGS2 TUBB3
Entrez ID		4361	3978
HPRD ID		02889	00534
Ensembl ID		ENSG00000020922	ENSG00000105486
Uniprot IDs		B3KTC7 P49959 Q05D78	B4DTU4 F5GZ28 P18858
PDB IDs		3T1I	1X9N
Enriched GO Terms of Interacting Partners?		DNA Recombination Double-strand Break Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair Via Homologous Recombination DNA Repair Recombinational Repair Cell Cycle Process DNA Metabolic Process Cellular Response To Stress Response To Ionizing Radiation Cell Cycle Telomere Maintenance Organelle Organization Response To Radiation Chromosome Organization DNA Damage Checkpoint Response To Stress Cell Cycle Checkpoint Response To Abiotic Stimulus Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process V(D)J Recombination Cellular Response To Stimulus Meiotic Cell Cycle Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process G2 DNA Damage Checkpoint DNA Replication Response To Gamma Radiation Response To Stimulus Positive Regulation Of Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Nonhomologous End Joining Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage DNA Conformation Change Signal Transduction By P53 Class Mediator Regulation Of Cellular Response To Heat Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Response To DNA Damage Stimulus Apoptotic Signaling Pathway Reproduction B Cell Activation Regulation Of Protein Metabolic Process	Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Cell Cycle Process Base-excision Repair Telomere Maintenance Nucleotide-excision Repair Positive Regulation Of Deoxyribonuclease Activity Regulation Of DNA Replication Leading Strand Elongation Mitotic Cell Cycle Checkpoint Negative Regulation Of DNA Endoreduplication Negative Regulation Of Mitotic Cell Cycle Regulation Of Catalytic Activity Cell Cycle Checkpoint Regulation Of Mitotic Recombination Regulation Of Adrenergic Receptor Signaling Pathway DNA Recombination Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of Phospholipase Activity DNA Replication Protein Folding Intra-S DNA Damage Checkpoint Relaxation Of Vascular Smooth Muscle Regulation Of DNA Endoreduplication Relaxation Of Smooth Muscle Telomere Maintenance Via Telomerase Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Translesion Synthesis Negative Regulation Of Muscle Hypertrophy Positive Regulation Of Microtubule Polymerization Relaxation Of Cardiac Muscle Negative Regulation Of Smooth Muscle Contraction Axon Guidance Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Hydrolase Activity Nucleotide-excision Repair, DNA Gap Filling Mitotic G2 DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Positive Regulation Of Catalytic Activity Cell Differentiation Positive Regulation Of Metabolic Process Telomere Maintenance Via Semi-conservative Replication Negative Regulation Of Cell Cycle Negative Regulation Of Lipase Activity Postreplication Repair Negative Regulation Of Muscle Contraction
Tagcloud ?		5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt nbn nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald	24h 300mum 513a 5p abp aminobiphenyl array arrays arylamine bioinformatic carcinogen comet damage deregulation eventually exo1 fancg hepg2 mirna mirnas parallel pcna pcr qrt rad18 repair ung validated xrcc2
Tagcloud (Difference) ?		5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt nbn nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald	24h 300mum 513a 5p abp aminobiphenyl array arrays arylamine bioinformatic carcinogen comet damage deregulation eventually exo1 fancg hepg2 mirna mirnas parallel pcna pcr qrt rad18 repair ung validated xrcc2
Tagcloud (Intersection) ?