MRE11A and RAD50

Number of citations of the paper that reports this interaction (PMID 10888888)
145

Data Source:
HPRD (in vivo, in vitro)

		MRE11A	RAD50
Gene Name		MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	RAD50 homolog (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytosol Mre11 Complex Site Of Double-strand Break	Nuclear Chromosome, Telomeric Region Nucleoplasm Membrane Mre11 Complex Site Of Double-strand Break Pronucleus
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Double-stranded DNA Binding ATP-dependent DNA Helicase Activity Nuclease Activity Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding 3'-5' Exonuclease Activity Manganese Ion Binding	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding ATP-dependent DNA Helicase Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Protein Binding, Bridging Metal Ion Binding
	Biological Process	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair Base-excision Repair Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Sister Chromatid Cohesion Mitotic G2 DNA Damage Checkpoint Synapsis Reciprocal Meiotic Recombination Cell Proliferation Intra-S DNA Damage Checkpoint Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Negative Regulation Of DNA Endoreduplication Positive Regulation Of Kinase Activity Innate Immune Response Nucleic Acid Phosphodiester Bond Hydrolysis	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair Double-strand Break Repair DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Reciprocal Meiotic Recombination Positive Regulation Of Protein Autophosphorylation DNA Duplex Unwinding Positive Regulation Of Kinase Activity Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Meiotic recombination DNA Damage/Telomere Stress Induced Senescence MRN complex relocalizes to nuclear foci Cytosolic sensors of pathogen-associated DNA Cellular Senescence Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks Homologous Recombination Repair STING mediated induction of host immune responses Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair IRF3-mediated induction of type I IFN Innate Immune System	DNA Damage/Telomere Stress Induced Senescence Meiotic recombination MRN complex relocalizes to nuclear foci Homologous Recombination Repair Cellular Senescence Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS			Asthma ( 20159242) IgE levels ( 18846228)
Protein-Protein Interactions		16 interactors: ATM ATR BRCA1 CCNE1 DCLRE1C EP300 FANCD2 H2AFX LIG1 NBN NEK1 PRKDC RAD50 RBBP8 RECQL5 XRCC6	8 interactors: DCLRE1C EP300 MDC1 MRE11A NBN RECQL5 RINT1 TERF2IP
Entrez ID		4361	10111
HPRD ID		02889	04950
Ensembl ID		ENSG00000020922	ENSG00000113522
Uniprot IDs		B3KTC7 P49959 Q05D78	A5D6Y3 Q92878
PDB IDs		3T1I
Enriched GO Terms of Interacting Partners?		DNA Recombination Double-strand Break Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair Via Homologous Recombination DNA Repair Recombinational Repair Cell Cycle Process DNA Metabolic Process Cellular Response To Stress Response To Ionizing Radiation Cell Cycle Telomere Maintenance Organelle Organization Response To Radiation Chromosome Organization DNA Damage Checkpoint Response To Stress Cell Cycle Checkpoint Response To Abiotic Stimulus Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process V(D)J Recombination Cellular Response To Stimulus Meiotic Cell Cycle Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process G2 DNA Damage Checkpoint DNA Replication Response To Gamma Radiation Response To Stimulus Positive Regulation Of Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Nonhomologous End Joining Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage DNA Conformation Change Signal Transduction By P53 Class Mediator Regulation Of Cellular Response To Heat Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Response To DNA Damage Stimulus Apoptotic Signaling Pathway Reproduction B Cell Activation Regulation Of Protein Metabolic Process	Cellular Response To DNA Damage Stimulus DNA Recombination Telomere Maintenance Cellular Response To Stress Double-strand Break Repair Chromosome Organization DNA Metabolic Process DNA Repair Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Homologous Recombination Recombinational Repair Mitotic DNA Damage Checkpoint Intra-S DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Telomere Maintenance Via Telomerase Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Cell Cycle Process Response To Stress Positive Regulation Of Protein Autophosphorylation Mitotic G2 DNA Damage Checkpoint DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint RNA-dependent DNA Replication Regulation Of Protein Autophosphorylation Negative Regulation Of Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Cell Cycle Checkpoint G2 DNA Damage Checkpoint Nucleobase-containing Compound Metabolic Process DNA Replication DNA Conformation Change Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process Regulation Of DNA Recombination Nitrogen Compound Metabolic Process Positive Regulation Of Type I Interferon Production Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Histone H2B Acetylation Negative Regulation Of DNA Recombination At Telomere Negative Regulation Of Cell Cycle DNA Catabolic Process, Endonucleolytic Negative Regulation Of DNA Metabolic Process Regulation Of Type I Interferon Production
Tagcloud ?		5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt nbn nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald	53bp1 applies atr coimmunoprecipitated colocalized combine damaging dda ddas dividing dynein etoposide explaining h2ax interphase microtubules mre11 mta mtas nbs1 p63 p95 pk sequestered sequesters slowly synergize traffic vincristine
Tagcloud (Difference) ?		5yrs atm brfr category cohorts ddr decisions fail gains gleason guided igrt nbn nibrin pca precision predictor predicts prkdc prostatectomy psa radioresistance radiotherapy radp sensing sensors wald	53bp1 applies coimmunoprecipitated colocalized combine damaging dda ddas dividing dynein etoposide explaining h2ax interphase microtubules mre11 mta mtas nbs1 p63 p95 pk sequestered sequesters slowly synergize traffic vincristine
Tagcloud (Intersection) ?		atr rad50