MRE11A and RBBP8

Number of citations of the paper that reports this interaction (PMID 25349192)
1

Data Source:
BioGRID (pull down)

		MRE11A	RBBP8
Gene Name		MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	retinoblastoma binding protein 8
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Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytosol Mre11 Complex Site Of Double-strand Break	Nucleus Nucleoplasm Nucleolus Transcriptional Repressor Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Double-stranded DNA Binding ATP-dependent DNA Helicase Activity Nuclease Activity Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding 3'-5' Exonuclease Activity Manganese Ion Binding	Single-stranded DNA Endodeoxyribonuclease Activity RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Corepressor Activity Damaged DNA Binding Protein Binding
	Biological Process	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair Base-excision Repair Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Sister Chromatid Cohesion Mitotic G2 DNA Damage Checkpoint Synapsis Reciprocal Meiotic Recombination Cell Proliferation Intra-S DNA Damage Checkpoint Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Negative Regulation Of DNA Endoreduplication Positive Regulation Of Kinase Activity Innate Immune Response Nucleic Acid Phosphodiester Bond Hydrolysis	Cell Cycle Checkpoint G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic Blastocyst Hatching DNA Repair Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Nuclear Division DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing G2 DNA Damage Checkpoint Cell Division Meiotic Cell Cycle
Pathways		Meiotic recombination DNA Damage/Telomere Stress Induced Senescence MRN complex relocalizes to nuclear foci Cytosolic sensors of pathogen-associated DNA Cellular Senescence Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks Homologous Recombination Repair STING mediated induction of host immune responses Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair IRF3-mediated induction of type I IFN Innate Immune System	Meiotic recombination
Drugs
Diseases
GWAS			Height ( 18391951) Intracranial aneurysm ( 20364137) Tuberculosis ( 20694014)
Protein-Protein Interactions		16 interactors: ATM ATR BRCA1 CCNE1 DCLRE1C EP300 FANCD2 H2AFX LIG1 NBN NEK1 PRKDC RAD50 RBBP8 RECQL5 XRCC6	34 interactors: ATM BARD1 BRCA1 CLU CTBP1 CTBP2 EEF1A1 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 LIMS1 LMO1 LMO2 LMO4 MAP2K4 MRE11A PCNA PIN1 PRKDC PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 SIAH1 SIAH2 TGIF2 TMEM54 WDYHV1
Entrez ID		4361	5932
HPRD ID		02889	04990
Ensembl ID		ENSG00000020922	ENSG00000101773
Uniprot IDs		B3KTC7 P49959 Q05D78	Q99708
PDB IDs		3T1I	2L4Z
Enriched GO Terms of Interacting Partners?		DNA Recombination Double-strand Break Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair Via Homologous Recombination DNA Repair Recombinational Repair Cell Cycle Process DNA Metabolic Process Cellular Response To Stress Response To Ionizing Radiation Cell Cycle Telomere Maintenance Organelle Organization Response To Radiation Chromosome Organization DNA Damage Checkpoint Response To Stress Cell Cycle Checkpoint Response To Abiotic Stimulus Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process V(D)J Recombination Cellular Response To Stimulus Meiotic Cell Cycle Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process G2 DNA Damage Checkpoint DNA Replication Response To Gamma Radiation Response To Stimulus Positive Regulation Of Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Nonhomologous End Joining Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage DNA Conformation Change Signal Transduction By P53 Class Mediator Regulation Of Cellular Response To Heat Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Response To DNA Damage Stimulus Apoptotic Signaling Pathway Reproduction B Cell Activation Regulation Of Protein Metabolic Process	Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Biosynthetic Process G2 DNA Damage Checkpoint Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Protein Metabolic Process Apoptotic Process Regulation Of Cell Death Cell Cycle Checkpoint Regulation Of Nucleic Acid-templated Transcription Programmed Cell Death Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Phosphorylation Cell Death Negative Regulation Of Gene Expression Death Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process DNA Damage Checkpoint Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Process Positive Regulation Of Protein Modification Process Telomere Maintenance Regulation Of Phosphorus Metabolic Process Response To Organic Substance Immune System Process Heterocycle Metabolic Process Regulation Of Transcription, DNA-templated Cellular Aromatic Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Double-strand Break Repair Via Homologous Recombination Recombinational Repair
Tagcloud ?		5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt nbn nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald	advance breaks cluster ctip doi downregulates downregulating dsbs elusive faithful genotoxic hypersensitivity impairs mechanistic microrna mir october onc oncogenic oncomir online polycistronic publication recombination repressed resection strand suppresses untranslated
Tagcloud (Difference) ?		5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt nbn nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald	advance breaks cluster ctip doi downregulates downregulating dsbs elusive faithful genotoxic hypersensitivity impairs mechanistic microrna mir october onc oncogenic oncomir online polycistronic publication recombination repressed resection strand suppresses untranslated
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