MRE11A

Gene Name		MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
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Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytosol Mre11 Complex Site Of Double-strand Break
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding Double-stranded DNA Binding ATP-dependent DNA Helicase Activity Nuclease Activity Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding 3'-5' Exonuclease Activity Manganese Ion Binding
	Biological Process	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Catabolic Process, Endonucleolytic DNA Repair Base-excision Repair Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Sister Chromatid Cohesion Mitotic G2 DNA Damage Checkpoint Synapsis Reciprocal Meiotic Recombination Cell Proliferation Intra-S DNA Damage Checkpoint Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Negative Regulation Of DNA Endoreduplication Positive Regulation Of Kinase Activity Innate Immune Response Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Meiotic recombination DNA Damage/Telomere Stress Induced Senescence MRN complex relocalizes to nuclear foci Cytosolic sensors of pathogen-associated DNA Cellular Senescence Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks Homologous Recombination Repair STING mediated induction of host immune responses Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair IRF3-mediated induction of type I IFN Innate Immune System
Drugs
Diseases
GWAS
Protein-protein Interactions		16 interactors: ATM ATR BRCA1 CCNE1 DCLRE1C EP300 FANCD2 H2AFX LIG1 NBN NEK1 PRKDC RAD50 RBBP8 RECQL5 XRCC6
Entrez ID		4361
HPRD ID		02889
Ensembl ID		ENSG00000020922
Uniprot IDs		B3KTC7 P49959 Q05D78
PDB IDs		3T1I
Enriched GO Terms of Interacting Partners?		DNA Recombination Double-strand Break Repair Cellular Response To DNA Damage Stimulus Double-strand Break Repair Via Homologous Recombination DNA Repair Recombinational Repair Cell Cycle Process DNA Metabolic Process Cellular Response To Stress Response To Ionizing Radiation Cell Cycle Telomere Maintenance Organelle Organization Response To Radiation Chromosome Organization DNA Damage Checkpoint Response To Stress Cell Cycle Checkpoint Response To Abiotic Stimulus Nucleobase-containing Compound Metabolic Process Mitotic Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process V(D)J Recombination Cellular Response To Stimulus Meiotic Cell Cycle Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process G2 DNA Damage Checkpoint DNA Replication Response To Gamma Radiation Response To Stimulus Positive Regulation Of Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway DNA Duplex Unwinding DNA Geometric Change Double-strand Break Repair Via Nonhomologous End Joining Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage DNA Conformation Change Signal Transduction By P53 Class Mediator Regulation Of Cellular Response To Heat Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Response To DNA Damage Stimulus Apoptotic Signaling Pathway Reproduction B Cell Activation Regulation Of Protein Metabolic Process
Tagcloud ?		5yrs atm atr brfr category cohorts ddr decisions fail gains gleason guided igrt nbn nibrin pca precision predictor predicts prkdc prostatectomy psa rad50 radioresistance radiotherapy radp sensing sensors wald