DNMT1 and HELLS

Number of citations of the paper that reports this interaction (PMID 17967891)
31

Data Source:
BioGRID (pull down)

		DNMT1	HELLS
Gene Name		DNA (cytosine-5-)-methyltransferase 1	helicase, lymphoid-specific
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin	Chromosome, Centromeric Region Nucleus Pericentric Heterochromatin
	Molecular Function	DNA Binding Chromatin Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity	DNA Binding Helicase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Transcription, DNA-templated Maintenance Of DNA Methylation Gene Expression Positive Regulation Of Gene Expression Gene Silencing Chromatin Modification DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine	Methylation-dependent Chromatin Silencing Transcription, DNA-templated Mitotic Nuclear Division Multicellular Organismal Development Maintenance Of DNA Methylation Pericentric Heterochromatin Assembly Lymphocyte Proliferation Cell Division
Pathways		NoRC negatively regulates rRNA expression Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA DNA methylation
Drugs		Azacitidine Procainamide Flucytosine Decitabine
Diseases
GWAS
Protein-Protein Interactions		31 interactors: AKT1 BAZ2A CBX1 CSNK2B DAXX DMAP1 DNMT3A DNMT3B DYNLL1 EED EZH2 GSK3B HDAC1 HDAC2 HELLS HMGB1 MECP2 NRIP1 PCNA RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SUV39H1 TRIM27 TSG101 UHRF1 USP7 YWHAQ	5 interactors: APP DNMT1 DNMT3B E2F3 HDAC1
Entrez ID		1786	3070
HPRD ID		00532	07232
Ensembl ID		ENSG00000130816	ENSG00000119969
Uniprot IDs		I6L9H2 P26358	Q9NRZ9
PDB IDs		3EPZ 3PTA 3SWR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Gene Expression Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromosome Organization Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Chromatin Silencing Organelle Organization Histone Modification DNA Methylation Gene Expression Methylation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Modification Nitrogen Compound Metabolic Process Transcription, DNA-templated Gene Silencing Chromatin Remodeling RNA Biosynthetic Process Regulation Of Gene Expression By Genetic Imprinting Cellular Macromolecule Biosynthetic Process Regulation Of Cellular Process RNA Metabolic Process Macromolecule Biosynthetic Process Genetic Imprinting Developmental Process Cell Cycle Histone Methylation Regulation Of Organelle Organization Multicellular Organismal Development Cellular Response To Stimulus Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process	C-5 Methylation Of Cytosine Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Gene Expression DNA Methylation On Cytosine Notch Signaling Pathway Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone Methylation Regulation Of Gene Expression, Epigenetic Regulation Of Histone H3-K4 Methylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Histone Methylation Regulation Of Histone Methylation DNA Methylation Cellular Response To Amino Acid Stimulus Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Histone Modification DNA Modification Negative Regulation Of Chromosome Organization Chromatin Modification Regulation Of Transcription From RNA Polymerase II Promoter Gene Silencing Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Amino Acid Regulation Of RNA Metabolic Process Chromatin Organization Regulation Of Histone Modification Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Gene Expression Synaptic Growth At Neuromuscular Junction Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Protein Metabolic Process Cellular Response To Acid Chemical Collateral Sprouting In Absence Of Injury S-adenosylmethioninamine Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Chromosome Organization Chromosome Organization DNA Methylation On Cytosine Within A CG Sequence DNA-templated Transcription, Initiation
Tagcloud ?		cpg cues de dense dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed	arrays atherosclerosis cpg cytosine dnmt1 e1 epigenetic fli1 friend hcys helicase homocysteine immunoblots integration janus linking lox lymphoid lysyl mc3t3 methyltransferases osteoblastic osteoblasts osteoclasts oxidase pathologies repressing repressive revealing
Tagcloud (Difference) ?		cues de dense dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed	arrays atherosclerosis cytosine e1 epigenetic fli1 friend hcys helicase homocysteine immunoblots integration janus linking lox lymphoid lysyl mc3t3 osteoblastic osteoblasts osteoclasts oxidase pathologies repressing repressive revealing
Tagcloud (Intersection) ?		cpg dnmt1 methyltransferases