HELLS and E2F3

Number of citations of the paper that reports this interaction (PMID 22157815)
5

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		HELLS	E2F3
Gene Name		helicase, lymphoid-specific	E2F transcription factor 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Pericentric Heterochromatin	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Golgi Apparatus Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Helicase Activity Protein Binding ATP Binding	Core Promoter Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Methylation-dependent Chromatin Silencing Transcription, DNA-templated Mitotic Nuclear Division Multicellular Organismal Development Maintenance Of DNA Methylation Pericentric Heterochromatin Assembly Lymphocyte Proliferation Cell Division	Mitotic Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated
Pathways			Signaling by NOTCH DNA Replication Pre-Initiation G1 Phase Cellular Senescence M/G1 Transition Regulation of DNA replication CDC6 association with the ORC:origin complex Oncogene Induced Senescence Cell Cycle, Mitotic Assembly of the pre-replicative complex Cyclin D associated events in G1 Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence G2 Phase Pre-NOTCH Expression and Processing Association of licensing factors with the pre-replicative complex Mitotic G2-G2/M phases Mitotic G1-G1/S phases
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: APP DNMT1 DNMT3B E2F3 HDAC1	23 interactors: ATAD2 CCNA2 CDK3 CREBBP FHL2 FZR1 HCFC1 HELLS MGA MYBL2 PKIB RB1 RNF144A RYBP SP1 SPIB SRA1 TEAD3 TFDP1 TFDP2 TFE3 WNK1 YY1
Entrez ID		3070	1871
HPRD ID		07232	02693
Ensembl ID		ENSG00000119969	ENSG00000112242
Uniprot IDs		Q9NRZ9	O00716 Q24JQ3
PDB IDs
Enriched GO Terms of Interacting Partners?		C-5 Methylation Of Cytosine Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Gene Expression DNA Methylation On Cytosine Notch Signaling Pathway Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone Methylation Regulation Of Gene Expression, Epigenetic Regulation Of Histone H3-K4 Methylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Histone Methylation Regulation Of Histone Methylation DNA Methylation Cellular Response To Amino Acid Stimulus Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Histone Modification DNA Modification Negative Regulation Of Chromosome Organization Chromatin Modification Regulation Of Transcription From RNA Polymerase II Promoter Gene Silencing Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Amino Acid Regulation Of RNA Metabolic Process Chromatin Organization Regulation Of Histone Modification Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Gene Expression Synaptic Growth At Neuromuscular Junction Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Protein Metabolic Process Cellular Response To Acid Chemical Collateral Sprouting In Absence Of Injury S-adenosylmethioninamine Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Chromosome Organization Chromosome Organization DNA Methylation On Cytosine Within A CG Sequence DNA-templated Transcription, Initiation	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Gene Expression Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Positive Regulation Of Metabolic Process Mitotic Nuclear Division Transcription Initiation From RNA Polymerase II Promoter Cellular Metabolic Process Cell Cycle DNA-templated Transcription, Initiation Mitotic Cell Cycle Process Regulation Of Cellular Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cellular Metabolic Process Cell Cycle Process Cell Division Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Enucleate Erythrocyte Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Transferase Activity Negative Regulation Of Biosynthetic Process Regulation Of Cell Cycle
Tagcloud ?		arrays atherosclerosis cpg cytosine dnmt1 e1 epigenetic fli1 friend hcys helicase homocysteine immunoblots integration janus linking lox lymphoid lysyl mc3t3 methyltransferases osteoblastic osteoblasts osteoclasts oxidase pathologies repressing repressive revealing	34a arrest carcinogenic chemokine concern concerned creates ct cytotoxicity doses frequent greatly involves ionizing killer mammographies medical micro mir mirna overexposure pathways patterns presentation radiation ray scans successfully workers
Tagcloud (Difference) ?		arrays atherosclerosis cpg cytosine dnmt1 e1 epigenetic fli1 friend hcys helicase homocysteine immunoblots integration janus linking lox lymphoid lysyl mc3t3 methyltransferases osteoblastic osteoblasts osteoclasts oxidase pathologies repressing repressive revealing	34a arrest carcinogenic chemokine concern concerned creates ct cytotoxicity doses frequent greatly involves ionizing killer mammographies medical micro mir mirna overexposure pathways patterns presentation radiation ray scans successfully workers
Tagcloud (Intersection) ?