HELLS and DNMT3B

Number of citations of the paper that reports this interaction (PMID 17967891)
31

Data Source:
BioGRID (pull down)

		HELLS	DNMT3B
Gene Name		helicase, lymphoid-specific	DNA (cytosine-5-)-methyltransferase 3 beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Pericentric Heterochromatin	Nucleus Nucleoplasm Nuclear Heterochromatin Cytoplasm Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Helicase Activity Protein Binding ATP Binding	Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Unmethylated CpG Binding Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates
	Biological Process	Methylation-dependent Chromatin Silencing Transcription, DNA-templated Mitotic Nuclear Division Multicellular Organismal Development Maintenance Of DNA Methylation Pericentric Heterochromatin Assembly Lymphocyte Proliferation Cell Division	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Methylation-dependent Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Response To Ionizing Radiation DNA Methylation On Cytosine Within A CG Sequence Gene Expression Positive Regulation Of Gene Expression Protein Complex Localization DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Response To Drug Positive Regulation Of Neuron Differentiation Negative Regulation Of Gene Expression, Epigenetic S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine
Pathways			NoRC negatively regulates rRNA expression Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA DNA methylation
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		5 interactors: APP DNMT1 DNMT3B E2F3 HDAC1	35 interactors: BAZ2A CBX1 CBX3 CBX5 CMTM6 DNMT1 DNMT3A DNMT3L DUSP23 EED EZH2 HDAC1 HDAC2 HELLS KIF4A MAP1LC3B MBD4 NCAPG NEDD8 NRIP1 PAM16 PCYT2 PLEKHJ1 RPS10 SMARCA5 SMC2 SPI1 SUMO1 SUV39H1 TDG TSC22D1 UBE2I UBE2W WARS ZBTB18
Entrez ID		3070	1789
HPRD ID		07232	04209
Ensembl ID		ENSG00000119969	ENSG00000088305
Uniprot IDs		Q9NRZ9	Q9UBC3
PDB IDs			3FLG 3QKJ
Enriched GO Terms of Interacting Partners?		C-5 Methylation Of Cytosine Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Gene Expression DNA Methylation On Cytosine Notch Signaling Pathway Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone Methylation Regulation Of Gene Expression, Epigenetic Regulation Of Histone H3-K4 Methylation Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Histone Methylation Regulation Of Histone Methylation DNA Methylation Cellular Response To Amino Acid Stimulus Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Histone Modification DNA Modification Negative Regulation Of Chromosome Organization Chromatin Modification Regulation Of Transcription From RNA Polymerase II Promoter Gene Silencing Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Amino Acid Regulation Of RNA Metabolic Process Chromatin Organization Regulation Of Histone Modification Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Gene Expression Synaptic Growth At Neuromuscular Junction Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Protein Metabolic Process Cellular Response To Acid Chemical Collateral Sprouting In Absence Of Injury S-adenosylmethioninamine Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Chromosome Organization Chromosome Organization DNA Methylation On Cytosine Within A CG Sequence DNA-templated Transcription, Initiation	Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process DNA Modification Chromatin Modification Chromosome Organization Chromatin Silencing Chromatin Organization Gene Silencing Nucleobase-containing Compound Metabolic Process DNA Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Organelle Organization Cellular Nitrogen Compound Metabolic Process DNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Cellular Metabolic Process Methylation Transcription, DNA-templated Histone H3-K9 Modification Chromatin Remodeling RNA Metabolic Process DNA Methylation On Cytosine Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Silencing At RDNA Histone Modification Peptidyl-lysine Modification Histone H4 Deacetylation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Rhythmic Process DNA Packaging Regulation Of Gene Expression By Genetic Imprinting Hypermethylation Of CpG Island C-5 Methylation Of Cytosine
Tagcloud ?		arrays atherosclerosis cpg cytosine dnmt1 e1 epigenetic fli1 friend hcys helicase homocysteine immunoblots integration janus linking lox lymphoid lysyl mc3t3 methyltransferases osteoblastic osteoblasts osteoclasts oxidase pathologies repressing repressive revealing	cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Difference) ?		arrays atherosclerosis cytosine e1 epigenetic fli1 friend hcys helicase homocysteine immunoblots integration janus linking lox lymphoid lysyl mc3t3 osteoblastic osteoblasts osteoclasts oxidase pathologies repressing repressive revealing	cues de dense dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Intersection) ?		cpg dnmt1 methyltransferases