DNMT1 and HDAC2

Number of citations of the paper that reports this interaction (PMID 10888872)
203

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		DNMT1	HDAC2
Gene Name		DNA (cytosine-5-)-methyltransferase 1	histone deacetylase 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin	Nuclear Chromatin Heterochromatin Nucleus Nucleoplasm Replication Fork Transcription Factor Complex Cytoplasm Sin3 Complex NuRD Complex ESC/E(Z) Complex Protein Complex
	Molecular Function	DNA Binding Chromatin Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Histone Deacetylase Activity Protein Binding Transcription Factor Binding Deacetylase Activity Enzyme Binding Heat Shock Protein Binding Nucleosomal DNA Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Krueppel-associated Box Domain Binding Sequence-specific DNA Binding Poly(A) RNA Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Transcription, DNA-templated Maintenance Of DNA Methylation Gene Expression Positive Regulation Of Gene Expression Gene Silencing Chromatin Modification DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Chromatin Remodeling Maintenance Of Chromatin Silencing Transcription, DNA-templated Blood Coagulation Positive Regulation Of Cell Proliferation Epidermal Cell Differentiation Gene Expression Positive Regulation Of Receptor Biosynthetic Process Negative Regulation Of Neuron Projection Development Dendrite Development Histone Deacetylation Hippocampus Development Circadian Regulation Of Gene Expression Positive Regulation Of Collagen Biosynthetic Process Cellular Response To Heat Regulation Of Gene Expression, Epigenetic Response To Cocaine Odontogenesis Of Dentin-containing Tooth Response To Drug Embryonic Digit Morphogenesis ATP-dependent Chromatin Remodeling Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Cell Cycle Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Sarcomere Organization Hair Follicle Placode Formation Eyelid Development In Camera-type Eye Fungiform Papilla Formation Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Deacetylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		NoRC negatively regulates rRNA expression Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA DNA methylation	Signaling by NOTCH1 HD Domain Mutants in Cancer RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NoRC negatively regulates rRNA expression Signaling by NOTCH1 Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer Signalling by NGF Chromatin organization HDACs deacetylate histones p75NTR negatively regulates cell cycle via SC1 RNA Polymerase I Transcription Signaling by NOTCH Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression p75 NTR receptor-mediated signalling Factors involved in megakaryocyte development and platelet production NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer Constitutive Signaling by NOTCH1 PEST Domain Mutants
Drugs		Azacitidine Procainamide Flucytosine Decitabine
Diseases
GWAS
Protein-Protein Interactions		31 interactors: AKT1 BAZ2A CBX1 CSNK2B DAXX DMAP1 DNMT3A DNMT3B DYNLL1 EED EZH2 GSK3B HDAC1 HDAC2 HELLS HMGB1 MECP2 NRIP1 PCNA RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SUV39H1 TRIM27 TSG101 UHRF1 USP7 YWHAQ	92 interactors: ANTXR1 APPL1 ARID4A AURKA BRCA1 BRMS1 BRMS1L BUB3 CDC20 CDH1 CDKN1A CDYL CHFR CIR1 CSNK2A1 CSNK2A2 CTBP1 DAXX DDX20 DMAP1 DNMT1 DNMT3B EED EID2 FKBP3 HDAC1 HDAC10 HDAC7 HIF1A HIF1AN HIST1H3A HIST1H4A HIST2H2AC HIST2H2BE HIST3H3 HOPX HUWE1 IFRD1 IKZF1 IKZF4 ING1 LINC00152 MAD1L1 MBD2 MBD3L2 MEN1 MTA1 MTA2 MXD1 NACC2 NRIP1 PA2G4 PADI4 PHB2 PHF21A PIAS4 PML PPARD PPP1R8 PTMA RBBP4 RBBP7 RBP1 RCOR1 RELA RFX5 RUNX3 SALL1 SAP30 SETDB1 SIN3A SMAD2 SMARCA5 SMYD1 SNW1 SP1 SP3 SPEN SS18L1 STAT3 SUV39H1 SYK TFCP2 THRA THRB TOP2A TOP2B TP53 VHL YY1 ZBTB16 ZNF461
Entrez ID		1786	3066
HPRD ID		00532	05521
Ensembl ID		ENSG00000130816	ENSG00000196591
Uniprot IDs		I6L9H2 P26358	Q92769
PDB IDs		3EPZ 3PTA 3SWR	3MAX 4LXZ 4LY1
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Gene Expression Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromosome Organization Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Chromatin Silencing Organelle Organization Histone Modification DNA Methylation Gene Expression Methylation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Modification Nitrogen Compound Metabolic Process Transcription, DNA-templated Gene Silencing Chromatin Remodeling RNA Biosynthetic Process Regulation Of Gene Expression By Genetic Imprinting Cellular Macromolecule Biosynthetic Process Regulation Of Cellular Process RNA Metabolic Process Macromolecule Biosynthetic Process Genetic Imprinting Developmental Process Cell Cycle Histone Methylation Regulation Of Organelle Organization Multicellular Organismal Development Cellular Response To Stimulus Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process	Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Chromosome Organization Regulation Of RNA Metabolic Process Regulation Of Gene Expression Gene Expression Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Modification Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Metabolic Process Organelle Organization Histone Modification Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Cell Differentiation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Process Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Chromosome Organization Histone Deacetylation Protein Deacetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Chromosome Organization Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cell Cycle
Tagcloud ?		cpg cues de dense dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed	abnormality accumbens ach3 adhd behavioural caudate deficit disrupted disruption dorsal exploratory habituation ht hydroxytryptamine hyperactivity mesocorticolimbic mesolimbic modulatory monoamine monoaminergic permanent putamen raphe serotonin tralpha tralpha0 trbeta trs
Tagcloud (Difference) ?		cpg cues de dense dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed	abnormality accumbens ach3 adhd behavioural caudate deficit disrupted disruption dorsal exploratory habituation ht hydroxytryptamine hyperactivity mesocorticolimbic mesolimbic modulatory monoamine monoaminergic permanent putamen raphe serotonin tralpha tralpha0 trbeta trs
Tagcloud (Intersection) ?