DNMT1 and RGS6

Number of citations of the paper that reports this interaction (PMID 14734556)
15

Data Source:
BioGRID (pull down)

		DNMT1	RGS6
Gene Name		DNA (cytosine-5-)-methyltransferase 1	regulator of G-protein signaling 6
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin	Cytoplasm Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane
	Molecular Function	DNA Binding Chromatin Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity	Signal Transducer Activity GTPase Activator Activity Protein Binding Protein Domain Specific Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Transcription, DNA-templated Maintenance Of DNA Methylation Gene Expression Positive Regulation Of Gene Expression Gene Silencing Chromatin Modification DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine	G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation
Pathways		NoRC negatively regulates rRNA expression Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA DNA methylation	Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events
Drugs		Azacitidine Procainamide Flucytosine Decitabine
Diseases
GWAS			C-reactive protein ( 21300955) Economic and political preferences (environmentalism) ( 22566634) Obesity (extreme) ( 21935397) Smoking cessation ( 20811658)
Protein-Protein Interactions		31 interactors: AKT1 BAZ2A CBX1 CSNK2B DAXX DMAP1 DNMT3A DNMT3B DYNLL1 EED EZH2 GSK3B HDAC1 HDAC2 HELLS HMGB1 MECP2 NRIP1 PCNA RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SUV39H1 TRIM27 TSG101 UHRF1 USP7 YWHAQ	4 interactors: DMAP1 DNMT1 GNB5 STMN2
Entrez ID		1786	9628
HPRD ID		00532	04871
Ensembl ID		ENSG00000130816	ENSG00000182732
Uniprot IDs		I6L9H2 P26358	B7Z2A0 B7Z2N1 B7Z7N5 P49758 Q2M3K2
PDB IDs		3EPZ 3PTA 3SWR	2ES0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Gene Expression Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromosome Organization Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Chromatin Silencing Organelle Organization Histone Modification DNA Methylation Gene Expression Methylation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Modification Nitrogen Compound Metabolic Process Transcription, DNA-templated Gene Silencing Chromatin Remodeling RNA Biosynthetic Process Regulation Of Gene Expression By Genetic Imprinting Cellular Macromolecule Biosynthetic Process Regulation Of Cellular Process RNA Metabolic Process Macromolecule Biosynthetic Process Genetic Imprinting Developmental Process Cell Cycle Histone Methylation Regulation Of Organelle Organization Multicellular Organismal Development Cellular Response To Stimulus Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process	DNA Methylation DNA Modification Regulation Of Gene Expression, Epigenetic C-5 Methylation Of Cytosine Positive Regulation Of Microtubule Depolymerization Negative Regulation Of Voltage-gated Calcium Channel Activity Maintenance Of DNA Methylation Positive Regulation Of Organelle Organization Histone H2A Acetylation DNA Methylation On Cytosine Methylation Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Microtubule Polymerization Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Negative Regulation Of Histone Methylation Positive Regulation Of Protein Depolymerization Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Chromatin Modification Regulation Of Histone H3-K4 Methylation Regulation Of Rhodopsin Mediated Signaling Pathway Cellular Response To Nerve Growth Factor Stimulus Regulation Of Microtubule Polymerization Positive Regulation Of Protein Complex Disassembly Rhodopsin Mediated Signaling Pathway Chromatin Organization Negative Regulation Of Microtubule Depolymerization Cellular Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Histone Methylation Positive Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Transporter Activity Negative Regulation Of Calcium Ion Transport Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Microtubule Polymerization Or Depolymerization Histone H4 Acetylation Regulation Of Organelle Organization Regulation Of Histone Methylation Negative Regulation Of Transmembrane Transport Cellular Response To Amino Acid Stimulus Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transport Chromosome Organization DNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Histone Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression, Epigenetic
Tagcloud ?		cpg cues de dense dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed	aberrations accelerated anthracene atm augmented carcinogen carcinogenic concurrent confirming countermeasure deficit dimethylbenza dmba ductal genotoxic glands interrogate mammary means mecs obtaining oncogenesis restore suppress suppressive underlie unsurprisingly utilize viable
Tagcloud (Difference) ?		cpg cues de dense dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed	aberrations accelerated anthracene atm augmented carcinogen carcinogenic concurrent confirming countermeasure deficit dimethylbenza dmba ductal genotoxic glands interrogate mammary means mecs obtaining oncogenesis restore suppress suppressive underlie unsurprisingly utilize viable
Tagcloud (Intersection) ?