DNMT1 and DMAP1

Number of citations of the paper that reports this interaction (PMID 10888872)
203

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		DNMT1	DMAP1
Gene Name		DNA (cytosine-5-)-methyltransferase 1	DNA methyltransferase 1 associated protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin	Nucleus Nucleoplasm Replication Fork Cytoplasm NuA4 Histone Acetyltransferase Complex
	Molecular Function	DNA Binding Chromatin Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity	RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Transcription Corepressor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Transcription, DNA-templated Maintenance Of DNA Methylation Gene Expression Positive Regulation Of Gene Expression Gene Silencing Chromatin Modification DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Repair DNA Methylation Chromatin Organization Chromatin Remodeling Transcription, DNA-templated Regulation Of Growth Positive Regulation Of Transcription Factor Import Into Nucleus Histone H4 Acetylation Histone H2A Acetylation Negative Regulation Of Transcription, DNA-templated
Pathways		NoRC negatively regulates rRNA expression Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA DNA methylation	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs		Azacitidine Procainamide Flucytosine Decitabine
Diseases
GWAS
Protein-Protein Interactions		31 interactors: AKT1 BAZ2A CBX1 CSNK2B DAXX DMAP1 DNMT3A DNMT3B DYNLL1 EED EZH2 GSK3B HDAC1 HDAC2 HELLS HMGB1 MECP2 NRIP1 PCNA RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SUV39H1 TRIM27 TSG101 UHRF1 USP7 YWHAQ	10 interactors: DAXX DNMT1 HDAC2 ING1 MNAT1 MRGBP RGS6 TOMM34 TSG101 URI1
Entrez ID		1786	55929
HPRD ID		00532	05465
Ensembl ID		ENSG00000130816	ENSG00000178028
Uniprot IDs		I6L9H2 P26358	B4DQG8 Q9NPF5
PDB IDs		3EPZ 3PTA 3SWR	3HM5 4IEJ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Gene Expression Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromosome Organization Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Chromatin Silencing Organelle Organization Histone Modification DNA Methylation Gene Expression Methylation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Modification Nitrogen Compound Metabolic Process Transcription, DNA-templated Gene Silencing Chromatin Remodeling RNA Biosynthetic Process Regulation Of Gene Expression By Genetic Imprinting Cellular Macromolecule Biosynthetic Process Regulation Of Cellular Process RNA Metabolic Process Macromolecule Biosynthetic Process Genetic Imprinting Developmental Process Cell Cycle Histone Methylation Regulation Of Organelle Organization Multicellular Organismal Development Cellular Response To Stimulus Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process	Chromatin Modification Regulation Of Growth Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression Chromatin Organization Chromosome Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Organelle Organization Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Gene Expression Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Cell Proliferation Regulation Of Cell Death Regulation Of Metabolic Process Regulation Of Cell Growth Regulation Of Cellular Component Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway RNA Metabolic Process Gene Silencing Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Maintenance Of Chromatin Silencing Viral Process Epidermal Cell Differentiation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cell Cycle C-5 Methylation Of Cytosine Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Regulation Of Extracellular Vesicular Exosome Assembly Maintenance Of DNA Methylation Negative Regulation Of MHC Class II Biosynthetic Process Chromatin Remodeling Positive Regulation Of Gene Expression Fungiform Papilla Formation Negative Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud ?		cpg cues de dense dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed	1p 1p34 ataxia atm avian cip1 coded dnmt1 doxo doxorubicin heterozygosity histology intriguingly loh mycn myelocytomatosis nb nbs neuroblastoma originates paediatric reagent situations stabilisation sympathetic telangiectasia tumourigenesis unfavourable waf1
Tagcloud (Difference) ?		cpg cues de dense dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed	1p 1p34 ataxia atm avian cip1 coded doxo doxorubicin heterozygosity histology intriguingly loh mycn myelocytomatosis nb nbs neuroblastoma originates paediatric reagent situations stabilisation sympathetic telangiectasia tumourigenesis unfavourable waf1
Tagcloud (Intersection) ?		dnmt1