DNMT1 and EED

Number of citations of the paper that reports this interaction (PMID 16357870)
388

Data Source:
BioGRID (imaging technique, affinity chromatography technology)
HPRD (in vitro)

		DNMT1	EED
Gene Name		DNA (cytosine-5-)-methyltransferase 1	embryonic ectoderm development
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin	Sex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm ESC/E(Z) Complex Pronucleus
	Molecular Function	DNA Binding Chromatin Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity	Chromatin Binding Protein Binding Histone Methyltransferase Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Transcription, DNA-templated Maintenance Of DNA Methylation Gene Expression Positive Regulation Of Gene Expression Gene Silencing Chromatin Modification DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Regulation Of Cell Proliferation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine	Regulation Of Gene Expression By Genetic Imprinting Transcription, DNA-templated Gene Expression Histone Methylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Histone H3-K27 Methylation
Pathways		NoRC negatively regulates rRNA expression Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA DNA methylation	Oxidative Stress Induced Senescence Cellular Senescence Epigenetic regulation of gene expression PRC2 methylates histones and DNA
Drugs		Azacitidine Procainamide Flucytosine Decitabine
Diseases
GWAS
Protein-Protein Interactions		31 interactors: AKT1 BAZ2A CBX1 CSNK2B DAXX DMAP1 DNMT3A DNMT3B DYNLL1 EED EZH2 GSK3B HDAC1 HDAC2 HELLS HMGB1 MECP2 NRIP1 PCNA RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SUV39H1 TRIM27 TSG101 UHRF1 USP7 YWHAQ	38 interactors: AEBP2 ANXA5 BRCA1 CDK2AP2 CTSL DNMT1 DNMT3A DNMT3B DUSP23 EHMT1 EPC2 EZH1 EZH2 FHL1 HDAC1 HDAC2 HDAC3 HIST1H1A HIST1H3A ITGA4 ITGAE ITGB7 MAP1LC3B NUDT21 PINK1 PJA1 PPP1CA PPP1R8 RBBP4 RPS10 SELENBP1 SMYD3 TGS1 TSC22D1 UBE2W YY1 ZBED8 ZFP42
Entrez ID		1786	8726
HPRD ID		00532	09343
Ensembl ID		ENSG00000130816	ENSG00000074266
Uniprot IDs		I6L9H2 P26358	E9PJK2 O75530
PDB IDs		3EPZ 3PTA 3SWR	3IIW 3IIY 3IJ0 3IJ1 3IJC 3JPX 3JZG 3JZH 3JZN 3K26 3K27
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Chromatin Modification Negative Regulation Of Gene Expression Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromosome Organization Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Chromatin Silencing Organelle Organization Histone Modification DNA Methylation Gene Expression Methylation Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Modification Nitrogen Compound Metabolic Process Transcription, DNA-templated Gene Silencing Chromatin Remodeling RNA Biosynthetic Process Regulation Of Gene Expression By Genetic Imprinting Cellular Macromolecule Biosynthetic Process Regulation Of Cellular Process RNA Metabolic Process Macromolecule Biosynthetic Process Genetic Imprinting Developmental Process Cell Cycle Histone Methylation Regulation Of Organelle Organization Multicellular Organismal Development Cellular Response To Stimulus Cellular Response To Stress Positive Regulation Of Cellular Metabolic Process	Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Expression, Epigenetic Chromatin Organization Chromosome Organization Chromatin Modification Negative Regulation Of Gene Expression DNA Methylation DNA Methylation On Cytosine Organelle Organization Negative Regulation Of Transcription, DNA-templated DNA Modification Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Methylation Negative Regulation Of Transcription From RNA Polymerase II Promoter C-5 Methylation Of Cytosine Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Histone H3-K9 Methylation Histone H3-K27 Methylation DNA Metabolic Process Chromatin Silencing Histone H3-K9 Modification Transcription, DNA-templated Gene Silencing Positive Regulation Of Histone H3-K4 Methylation Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Negative Regulation Of Histone Methylation Cell-matrix Adhesion Involved In Ameboidal Cell Migration Histone H4 Deacetylation Cellular Metabolic Process Regulation Of Histone H3-K4 Methylation Cellular Macromolecule Biosynthetic Process Circadian Regulation Of Gene Expression RNA Metabolic Process Macromolecule Biosynthetic Process
Tagcloud ?		cpg cues de dense dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed	70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic lethal mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Difference) ?		cpg cues de dense dnmt3a dnmt3b dnmts enhancers ensure ensures establishment excluded guide localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed	70z bait cdnas coexpressed coimmunoprecipitated compositions confirming developmentally drosophila ectoderm esc ezh2 fragment gal4 homolog hybrid hypomorphic mammalian polycomb repeats represses repressor silenced t1031a t1040c wd40 yeast zeste
Tagcloud (Intersection) ?		lethal