COL5A1 and LGALS3BP

Number of citations of the paper that reports this interaction (PMID 9501082)
21

Data Source:
HPRD (in vivo, in vitro)

		COL5A1	LGALS3BP
Gene Name		collagen, type V, alpha 1	lectin, galactoside-binding, soluble, 3 binding protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type V Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Vesicular Exosome	Proteinaceous Extracellular Matrix Extracellular Space Membrane Extracellular Matrix Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Heparin Binding Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Scavenger Receptor Activity
	Biological Process	Blood Vessel Development Heart Morphogenesis Cell Adhesion Axon Guidance Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Collagen Biosynthetic Process Wound Healing, Spreading Of Epidermal Cells Tendon Development Extracellular Fibril Organization Skin Development Integrin Biosynthetic Process Eye Morphogenesis Regulation Of Cellular Component Organization Negative Regulation Of Endodermal Cell Differentiation	Receptor-mediated Endocytosis Cellular Defense Response Cell Adhesion Signal Transduction
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Syndecan interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Central corneal thickness ( 22814818 23493294 20719862) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) Longevity ( 20834067)
Protein-Protein Interactions		10 interactors: BMP1 COL5A3 DCN LGALS3BP MAG PDGFA PDGFB SDC3 SPARC THBS1	11 interactors: CD14 COL5A1 COL6A1 FN1 ITGB1 LGALS1 LGALS3 NID1 PPIC SELE XRN1
Entrez ID		1289	3959
HPRD ID		00368	02796
Ensembl ID		ENSG00000130635	ENSG00000108679
Uniprot IDs		B2ZZ86 P20908 Q59EE7	B4DWA8 Q08380
PDB IDs		1A89 1A9A	1BY2
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Wound Healing Response To Wounding Negative Regulation Of Phosphatidylinositol Biosynthetic Process Blood Coagulation Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Hemostasis Negative Regulation Of Phospholipid Biosynthetic Process Platelet Activation Response To External Stimulus Positive Regulation Of Endothelial Cell Migration Response To Abiotic Stimulus Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Platelet-derived Growth Factor Receptor-beta Signaling Pathway Response To Growth Factor Organ Development Positive Regulation Of Epithelial Cell Migration Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell Migration Extracellular Matrix Disassembly Positive Regulation Of Cell Motility Exocytosis Regulation Of Blood Coagulation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Endothelial Cell Migration Response To Lipid Positive Regulation Of Protein Autophosphorylation Regulation Of Wound Healing Negative Regulation Of Platelet Activation Regulation Of Epithelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Organ Morphogenesis System Development Response To Steroid Hormone Secretion By Cell Regulation Of Protein Autophosphorylation Regulation Of Cell Migration Regulation Of Platelet Activation Negative Regulation Of Endothelial Cell Proliferation Multicellular Organismal Development Positive Regulation Of MAP Kinase Activity Locomotion Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Motility Secretion	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Regulation Of Endocytosis Calcium-independent Cell-matrix Adhesion Leukocyte Migration Cell Adhesion Regulation Of Cellular Component Organization Locomotion Response To Wounding Positive Regulation Of Endocytosis Leukocyte Tethering Or Rolling Regulation Of Vesicle-mediated Transport Cell Migration Movement Of Cell Or Subcellular Component Formation Of Primary Germ Layer Cell Motility Cell-matrix Adhesion Response To External Stimulus Regulation Of Cell-substrate Adhesion Cellular Extravasation Gastrulation Cell-substrate Adhesion Wound Healing Chemotaxis Regulation Of Cell Adhesion Endodermal Cell Differentiation Regulation Of Immune System Process Immune System Process Defense Response Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Response To Stress Endoderm Formation Positive Regulation Of Cell Migration Generation Of Neurons Collagen Catabolic Process Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Negative Regulation Of Immunological Synapse Formation Integrin Biosynthetic Process Positive Regulation Of Erythrocyte Aggregation Neurogenesis Positive Regulation Of Immune System Process Positive Regulation Of Cell Adhesion Regulation Of Neuron Projection Development Collagen Metabolic Process Tissue Development Axon Guidance
Tagcloud ?		acan adamts5 aggrecan ameliorates articular chondrogenic degradative erosion fibrogenic fluorotagged ha hyaluronan joints macroscopically meniscal meniscus mmp13 oa periarticular safranin subchondral synovium tgfbeta1 treadmill ttr	angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 maged1 mep1b metoestrus muc16 oestrogens oestrous oestrus pcsk5 plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1
Tagcloud (Difference) ?		acan adamts5 aggrecan ameliorates articular chondrogenic degradative erosion fibrogenic fluorotagged ha hyaluronan joints macroscopically meniscal meniscus mmp13 oa periarticular safranin subchondral synovium tgfbeta1 treadmill ttr	angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 maged1 mep1b metoestrus muc16 oestrogens oestrous oestrus pcsk5 plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1
Tagcloud (Intersection) ?