LGALS3BP and XRN1

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		LGALS3BP	XRN1
Gene Name		lectin, galactoside-binding, soluble, 3 binding protein	5-3 exoribonuclease 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Proteinaceous Extracellular Matrix Extracellular Space Membrane Extracellular Matrix Extracellular Vesicular Exosome Blood Microparticle	Cytoplasmic MRNA Processing Body Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Intermediate Filament Cytoskeleton
	Molecular Function	Scavenger Receptor Activity	DNA Binding Exonuclease Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Receptor-mediated Endocytosis Cellular Defense Response Cell Adhesion Signal Transduction	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Gene Expression RRNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Histone MRNA Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways			Regulation of mRNA stability by proteins that bind AU-rich elements mRNA decay by 5' to 3' exoribonuclease Tristetraprolin (TTP) destabilizes mRNA Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CD14 COL5A1 COL6A1 FN1 ITGB1 LGALS1 LGALS3 NID1 PPIC SELE XRN1	62 interactors: ALDOA ANGPTL6 AP1G2 ATP5G2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CD97 CENPBD1 CHD4 CTSB CTSH DCP1A DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 GLMP HEATR1 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MTCH2 NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SKIV2L2 SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPAL ZFP36
Entrez ID		3959	54464
HPRD ID		02796	10470
Ensembl ID		ENSG00000108679	ENSG00000114127
Uniprot IDs		B4DWA8 Q08380	Q8IZH2
PDB IDs		1BY2
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Regulation Of Endocytosis Calcium-independent Cell-matrix Adhesion Leukocyte Migration Cell Adhesion Regulation Of Cellular Component Organization Locomotion Response To Wounding Positive Regulation Of Endocytosis Leukocyte Tethering Or Rolling Regulation Of Vesicle-mediated Transport Cell Migration Movement Of Cell Or Subcellular Component Formation Of Primary Germ Layer Cell Motility Cell-matrix Adhesion Response To External Stimulus Regulation Of Cell-substrate Adhesion Cellular Extravasation Gastrulation Cell-substrate Adhesion Wound Healing Chemotaxis Regulation Of Cell Adhesion Endodermal Cell Differentiation Regulation Of Immune System Process Immune System Process Defense Response Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Response To Stress Endoderm Formation Positive Regulation Of Cell Migration Generation Of Neurons Collagen Catabolic Process Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Negative Regulation Of Immunological Synapse Formation Integrin Biosynthetic Process Positive Regulation Of Erythrocyte Aggregation Neurogenesis Positive Regulation Of Immune System Process Positive Regulation Of Cell Adhesion Regulation Of Neuron Projection Development Collagen Metabolic Process Tissue Development Axon Guidance	RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RRNA Processing RNA Processing RRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Generation Of Precursor Metabolites And Energy Ribosome Biogenesis Cellular Metabolic Process Respiratory Electron Transport Chain Electron Transport Chain RNA Splicing RNA Localization RNA Export From Nucleus Gene Expression Cellular Respiration MRNA Processing Energy Derivation By Oxidation Of Organic Compounds Ribonucleoprotein Complex Biogenesis Cellular Process Nuclear MRNA Surveillance Metabolic Process Nuclear Export MRNA Transport RNA Surveillance MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Histone MRNA Catabolic Process ATP Metabolic Process Dosage Compensation By Inactivation Of X Chromosome Cellular Response To Thyroid Hormone Stimulus RNA Transport RNA Destabilization Dosage Compensation MRNA Export From Nucleus Posttranscriptional Regulation Of Gene Expression
Tagcloud ?		angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 maged1 mep1b metoestrus muc16 oestrogens oestrous oestrus pcsk5 plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1	alters artificial avirulence bisexual capsule changing constantly coordinated corresponds cryptococcosis cryptococcus encountering environments exonuclease habitat impairs interdependent invertebrate lac1 mating melanin neoformans opportunistic rrp44 uni virulence xrn1delta xrn1p xrn2
Tagcloud (Difference) ?		angptl2 cldn10 cldn4 cst6 dioestrus enpp1 epas1 itgb4 maged1 mep1b metoestrus muc16 oestrogens oestrous oestrus pcsk5 plat preoestrus sepp1 simmental slc11a2 slc16a1 slc1a1 tdgf1 tek timp1 timp2 tjp1	alters artificial avirulence bisexual capsule changing constantly coordinated corresponds cryptococcosis cryptococcus encountering environments exonuclease habitat impairs interdependent invertebrate lac1 mating melanin neoformans opportunistic rrp44 uni virulence xrn1delta xrn1p xrn2
Tagcloud (Intersection) ?