COL5A1 and PDGFB

Number of citations of the paper that reports this interaction (PMID 8900172)
4

Data Source:
BioGRID (pull down, far western blotting)

		COL5A1	PDGFB
Gene Name		collagen, type V, alpha 1	platelet-derived growth factor beta polypeptide
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type V Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Vesicular Exosome	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Cell Surface Basolateral Plasma Membrane Platelet Alpha Granule Lumen
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Heparin Binding Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-derived Growth Factor Binding
	Biological Process	Blood Vessel Development Heart Morphogenesis Cell Adhesion Axon Guidance Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Collagen Biosynthetic Process Wound Healing, Spreading Of Epidermal Cells Tendon Development Extracellular Fibril Organization Skin Development Integrin Biosynthetic Process Eye Morphogenesis Regulation Of Cellular Component Organization Negative Regulation Of Endodermal Cell Differentiation	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Platelet Degranulation Positive Regulation Of Glomerular Filtration DNA Replication Protein Phosphorylation Substrate-dependent Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Blood Coagulation Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Wounding Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Cell Growth Peptidyl-serine Phosphorylation Peptidyl-tyrosine Phosphorylation Cell Projection Assembly Actin Cytoskeleton Organization Hemopoiesis Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Response To Estradiol Response To Insulin Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Paracrine Signaling Fc-epsilon Receptor Signaling Pathway Response To Drug Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Replication Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle, Embryonic Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Chemotaxis Cell Chemotaxis Branching Involved In Salivary Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Mycophenolic Acid Positive Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Glomerular Mesangial Cell Development Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Metanephric Glomerular Endothelium Development Reactive Oxygen Species Metabolic Process Positive Regulation Of Calcium Ion Import Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Syndecan interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Platelet degranulation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Response to elevated platelet cytosolic Ca2+ Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Non-integrin membrane-ECM interactions Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System
Drugs
Diseases
GWAS		Central corneal thickness ( 22814818 23493294 20719862) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) Longevity ( 20834067)
Protein-Protein Interactions		10 interactors: BMP1 COL5A3 DCN LGALS3BP MAG PDGFA PDGFB SDC3 SPARC THBS1	20 interactors: A2M ART1 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 HNRNPC HRAS HSPG2 LRP1 LYVE1 MDFI PDAP1 PDGFRA PDGFRB SPARC THBS1
Entrez ID		1289	5155
HPRD ID		00368	01815
Ensembl ID		ENSG00000130635	ENSG00000100311
Uniprot IDs		B2ZZ86 P20908 Q59EE7	P01127
PDB IDs		1A89 1A9A	1PDG 3MJG 4HQU 4HQX
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Wound Healing Response To Wounding Negative Regulation Of Phosphatidylinositol Biosynthetic Process Blood Coagulation Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Hemostasis Negative Regulation Of Phospholipid Biosynthetic Process Platelet Activation Response To External Stimulus Positive Regulation Of Endothelial Cell Migration Response To Abiotic Stimulus Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Platelet-derived Growth Factor Receptor-beta Signaling Pathway Response To Growth Factor Organ Development Positive Regulation Of Epithelial Cell Migration Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell Migration Extracellular Matrix Disassembly Positive Regulation Of Cell Motility Exocytosis Regulation Of Blood Coagulation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Endothelial Cell Migration Response To Lipid Positive Regulation Of Protein Autophosphorylation Regulation Of Wound Healing Negative Regulation Of Platelet Activation Regulation Of Epithelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Organ Morphogenesis System Development Response To Steroid Hormone Secretion By Cell Regulation Of Protein Autophosphorylation Regulation Of Cell Migration Regulation Of Platelet Activation Negative Regulation Of Endothelial Cell Proliferation Multicellular Organismal Development Positive Regulation Of MAP Kinase Activity Locomotion Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Motility Secretion	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Cardiovascular System Development Multicellular Organismal Metabolic Process Response To Wounding Blood Vessel Development Vasculature Development Skeletal System Development Cellular Response To Amino Acid Stimulus Anatomical Structure Morphogenesis Wound Healing Organ Morphogenesis Response To External Stimulus Platelet Activation Movement Of Cell Or Subcellular Component Cellular Response To Growth Factor Stimulus Response To Amino Acid Developmental Process Response To Growth Factor Locomotion Blood Coagulation Hemostasis Skeletal System Morphogenesis Collagen Fibril Organization Heart Development Cellular Response To Acid Chemical Regulation Of Body Fluid Levels Regulation Of Cell Migration Chemotaxis Anatomical Structure Development Regulation Of Cell Motility Cartilage Development Involved In Endochondral Bone Morphogenesis Response To Stimulus Tissue Development System Development Endocytosis Blood Vessel Morphogenesis Connective Tissue Development Regulation Of Locomotion Regulation Of Cellular Component Movement Cellular Response To Organic Substance Organ Development Cellular Response To Organonitrogen Compound Ossification Protein Heterotrimerization Cellular Response To Stimulus
Tagcloud ?		acan adamts5 aggrecan ameliorates articular chondrogenic degradative erosion fibrogenic fluorotagged ha hyaluronan joints macroscopically meniscal meniscus mmp13 oa periarticular safranin subchondral synovium tgfbeta1 treadmill ttr	5b alone angiogenesis associates aurora coexpression dataset ectopic effector glioblastomas glioma gliomas grade isoform latent mesenchymal modeled pn predominantly promoters proneural reveals shorter stat5 stat5b tcga transducer xl yielded
Tagcloud (Difference) ?		acan adamts5 aggrecan ameliorates articular chondrogenic degradative erosion fibrogenic fluorotagged ha hyaluronan joints macroscopically meniscal meniscus mmp13 oa periarticular safranin subchondral synovium tgfbeta1 treadmill ttr	5b alone angiogenesis associates aurora coexpression dataset ectopic effector glioblastomas glioma gliomas grade isoform latent mesenchymal modeled pn predominantly promoters proneural reveals shorter stat5 stat5b tcga transducer xl yielded
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