COL5A1 and BMP1

Number of citations of the paper that reports this interaction (PMID 11741999)
25

Data Source:
HPRD (in vivo)

		COL5A1	BMP1
Gene Name		collagen, type V, alpha 1	bone morphogenetic protein 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type V Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Apparatus Membrane-bounded Vesicle
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Heparin Binding Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Metalloendopeptidase Activity Cytokine Activity Calcium Ion Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Blood Vessel Development Heart Morphogenesis Cell Adhesion Axon Guidance Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Collagen Biosynthetic Process Wound Healing, Spreading Of Epidermal Cells Tendon Development Extracellular Fibril Organization Skin Development Integrin Biosynthetic Process Eye Morphogenesis Regulation Of Cellular Component Organization Negative Regulation Of Endodermal Cell Differentiation	Skeletal System Development Cartilage Condensation Ossification Proteolysis Multicellular Organismal Development Extracellular Matrix Disassembly Cell Differentiation Extracellular Matrix Organization Lipoprotein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Cartilage Development
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Syndecan interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth	Collagen formation Crosslinking of collagen fibrils Anchoring fibril formation Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS		Central corneal thickness ( 22814818 23493294 20719862) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) Longevity ( 20834067)	Hypertriglyceridemia ( 23505323)
Protein-Protein Interactions		10 interactors: BMP1 COL5A3 DCN LGALS3BP MAG PDGFA PDGFB SDC3 SPARC THBS1	14 interactors: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1
Entrez ID		1289	649
HPRD ID		00368	00209
Ensembl ID		ENSG00000130635	ENSG00000168487
Uniprot IDs		B2ZZ86 P20908 Q59EE7	P13497
PDB IDs		1A89 1A9A	3EDG 3EDH
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Wound Healing Response To Wounding Negative Regulation Of Phosphatidylinositol Biosynthetic Process Blood Coagulation Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Hemostasis Negative Regulation Of Phospholipid Biosynthetic Process Platelet Activation Response To External Stimulus Positive Regulation Of Endothelial Cell Migration Response To Abiotic Stimulus Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Platelet-derived Growth Factor Receptor-beta Signaling Pathway Response To Growth Factor Organ Development Positive Regulation Of Epithelial Cell Migration Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell Migration Extracellular Matrix Disassembly Positive Regulation Of Cell Motility Exocytosis Regulation Of Blood Coagulation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Endothelial Cell Migration Response To Lipid Positive Regulation Of Protein Autophosphorylation Regulation Of Wound Healing Negative Regulation Of Platelet Activation Regulation Of Epithelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Organ Morphogenesis System Development Response To Steroid Hormone Secretion By Cell Regulation Of Protein Autophosphorylation Regulation Of Cell Migration Regulation Of Platelet Activation Negative Regulation Of Endothelial Cell Proliferation Multicellular Organismal Development Positive Regulation Of MAP Kinase Activity Locomotion Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Motility Secretion	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Gastrulation Tissue Development Formation Of Primary Germ Layer Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Hemidesmosome Assembly Collagen Catabolic Process Embryo Development Anatomical Structure Morphogenesis Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Anatomical Structure Development Ossification Negative Regulation Of Endodermal Cell Differentiation Epithelium Development Developmental Process Endodermal Cell Differentiation Cell Differentiation Cell-substrate Junction Assembly Multicellular Organismal Development Endoderm Formation Collagen Fibril Organization Epidermis Development Endoderm Development Collagen Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Adhesion Regulation Of Embryonic Development Negative Regulation Of Cell Differentiation Head Development Organ Development Negative Regulation Of Embryonic Development Regulation Of Cell Differentiation Organ Morphogenesis Cell Junction Assembly Regulation Of Gastrulation Cartilage Development Involved In Endochondral Bone Morphogenesis Skeletal System Development Endochondral Ossification Skin Development Negative Regulation Of BMP Signaling Pathway Response To External Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Negative Regulation Of Osteoblast Differentiation Cellular Response To Amino Acid Stimulus
Tagcloud ?		acan adamts5 aggrecan ameliorates articular chondrogenic degradative erosion fibrogenic fluorotagged ha hyaluronan joints macroscopically meniscal meniscus mmp13 oa periarticular safranin subchondral synovium tgfbeta1 treadmill ttr	augment c1r c1s cub embryogenesis fli1a founding gata1 hbbe1 hematopoiesis hierarchy injecting maternally mesoderm morphants morphogenetic morpholino mount mpo myelomonocytic oligonucleotide plastin primitive pu scube scube1 uegf zebrafish
Tagcloud (Difference) ?		acan adamts5 aggrecan ameliorates articular chondrogenic degradative erosion fibrogenic fluorotagged ha hyaluronan joints macroscopically meniscal meniscus mmp13 oa periarticular safranin subchondral synovium tgfbeta1 treadmill ttr	augment c1r c1s cub embryogenesis fli1a founding gata1 hbbe1 hematopoiesis hierarchy injecting maternally mesoderm morphants morphogenetic morpholino mount mpo myelomonocytic oligonucleotide plastin primitive pu scube scube1 uegf zebrafish
Tagcloud (Intersection) ?