COL5A1 and SDC3

Number of citations of the paper that reports this interaction (PMID 11751872)
6

Data Source:
HPRD (in vitro)

		COL5A1	SDC3
Gene Name		collagen, type V, alpha 1	syndecan 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type V Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Vesicular Exosome	Golgi Lumen Plasma Membrane Membrane Integral Component Of Membrane Lysosomal Lumen
	Molecular Function	Integrin Binding Extracellular Matrix Structural Constituent Heparin Binding Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Blood Vessel Development Heart Morphogenesis Cell Adhesion Axon Guidance Cell Migration Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Collagen Biosynthetic Process Wound Healing, Spreading Of Epidermal Cells Tendon Development Extracellular Fibril Organization Skin Development Integrin Biosynthetic Process Eye Morphogenesis Regulation Of Cellular Component Organization Negative Regulation Of Endodermal Cell Differentiation	Retinoid Metabolic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Small Molecule Metabolic Process
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Syndecan interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Diseases associated with visual transduction Defective EXT1 causes exostoses 1, TRPS2 and CHDS Syndecan interactions MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Central corneal thickness ( 22814818 23493294 20719862) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) Longevity ( 20834067)
Protein-Protein Interactions		10 interactors: BMP1 COL5A3 DCN LGALS3BP MAG PDGFA PDGFB SDC3 SPARC THBS1	15 interactors: CASK COL5A1 CSK CTTN CUX1 EPHB4 FGF2 FYN KRTAP10-3 KRTAP5-9 MDK PTN TUBA1A TUBB TUBB2A
Entrez ID		1289	9672
HPRD ID		00368	01719
Ensembl ID		ENSG00000130635
Uniprot IDs		B2ZZ86 P20908 Q59EE7	O75056
PDB IDs		1A89 1A9A
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Platelet Degranulation Wound Healing Response To Wounding Negative Regulation Of Phosphatidylinositol Biosynthetic Process Blood Coagulation Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Hemostasis Negative Regulation Of Phospholipid Biosynthetic Process Platelet Activation Response To External Stimulus Positive Regulation Of Endothelial Cell Migration Response To Abiotic Stimulus Cellular Response To Growth Factor Stimulus Regulation Of Body Fluid Levels Platelet-derived Growth Factor Receptor-beta Signaling Pathway Response To Growth Factor Organ Development Positive Regulation Of Epithelial Cell Migration Regulation Of Endothelial Cell Proliferation Positive Regulation Of Cell Migration Extracellular Matrix Disassembly Positive Regulation Of Cell Motility Exocytosis Regulation Of Blood Coagulation Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Endothelial Cell Migration Response To Lipid Positive Regulation Of Protein Autophosphorylation Regulation Of Wound Healing Negative Regulation Of Platelet Activation Regulation Of Epithelial Cell Migration Positive Regulation Of Blood Vessel Endothelial Cell Migration Organ Morphogenesis System Development Response To Steroid Hormone Secretion By Cell Regulation Of Protein Autophosphorylation Regulation Of Cell Migration Regulation Of Platelet Activation Negative Regulation Of Endothelial Cell Proliferation Multicellular Organismal Development Positive Regulation Of MAP Kinase Activity Locomotion Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Motility Secretion	Cell Migration Cell Motility Protein Polymerization Movement Of Cell Or Subcellular Component Nervous System Development Locomotion Anatomical Structure Development Organ Development System Development Developmental Process Response To Wounding Cellular Protein Complex Assembly Multicellular Organismal Development Positive Regulation Of Cell Division Cell Migration Involved In Sprouting Angiogenesis Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Vessel Endothelial Cell Migration Neurogenesis Protein Autophosphorylation Cell Differentiation Peptidyl-tyrosine Autophosphorylation Tissue Development Epithelium Development Neuron Differentiation Wound Healing Chemotaxis Cellular Macromolecular Complex Assembly Neuron Projection Morphogenesis Cell Adhesion Regulation Of Cell Division Learning Or Memory Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Sprouting Angiogenesis 'de Novo' Posttranslational Protein Folding Cognition 'de Novo' Protein Folding Defecation Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Integrin Biosynthetic Process Cellular Response To Peptide Hormone Stimulus Defense Response Negative Regulation Of Wound Healing Cellular Response To Peptide T Cell Costimulation Innate Immune Response Neuron Projection Development Endothelial Cell Migration
Tagcloud ?		acan adamts5 aggrecan ameliorates articular chondrogenic degradative erosion fibrogenic fluorotagged ha hyaluronan joints macroscopically meniscal meniscus mmp13 oa periarticular safranin subchondral synovium tgfbeta1 treadmill ttr	artemin artn benign carcinoma diverse gfralpha1 gfralpha3 herein invasiveness largely malignancies mammary mediating metastases namely node oncogenicity outcome positively positivity predictors promoting relapse restricted significance syndecan synergistic univariate upstream
Tagcloud (Difference) ?		acan adamts5 aggrecan ameliorates articular chondrogenic degradative erosion fibrogenic fluorotagged ha hyaluronan joints macroscopically meniscal meniscus mmp13 oa periarticular safranin subchondral synovium tgfbeta1 treadmill ttr	artemin artn benign carcinoma diverse gfralpha1 gfralpha3 herein invasiveness largely malignancies mammary mediating metastases namely node oncogenicity outcome positively positivity predictors promoting relapse restricted significance syndecan synergistic univariate upstream
Tagcloud (Intersection) ?