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ADAR |
adenosine deaminase RNA specific |
- C6 deamination of adenosine
- Formation of editosomes by ADAR proteins
- Interferon alpha/beta signaling
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- Dyschromatosis symmetrica hereditaria
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AFP |
alpha fetoprotein |
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- Post-translational protein phosphorylation
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AKAP12 |
A-kinase anchoring protein 12 |
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ALYREF |
Aly/REF export factor |
- Transport of the SLBP independent Mature mRNA
- Transport of the SLBP Dependant Mature mRNA
- Transport of Mature mRNA Derived from an Intronless Transcript
- Transport of Mature mRNA derived from an Intron-Containing Transcript
- mRNA Splicing - Major Pathway
- mRNA 3'-end processing
- RNA Polymerase II Transcription Termination
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AMOT |
angiomotin |
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ANAPC10 |
anaphase promoting complex subunit 10 |
- Inactivation of APC/C via direct inhibition of the APC/C complex
- APC/C:Cdc20 mediated degradation of Cyclin B
- Autodegradation of Cdh1 by Cdh1:APC/C
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
- Regulation of APC/C activators between G1/S and early anaphase
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Phosphorylation of the APC/C
- APC-Cdc20 mediated degradation of Nek2A
- Separation of Sister Chromatids
- Senescence-Associated Secretory Phenotype (SASP)
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional Regulation by VENTX
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Antigen processing: Ubiquitination & Proteasome degradation
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ANAPC7 |
anaphase promoting complex subunit 7 |
- Inactivation of APC/C via direct inhibition of the APC/C complex
- APC/C:Cdc20 mediated degradation of Cyclin B
- Autodegradation of Cdh1 by Cdh1:APC/C
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
- Regulation of APC/C activators between G1/S and early anaphase
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Phosphorylation of the APC/C
- APC-Cdc20 mediated degradation of Nek2A
- Separation of Sister Chromatids
- Senescence-Associated Secretory Phenotype (SASP)
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional Regulation by VENTX
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Antigen processing: Ubiquitination & Proteasome degradation
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ANG |
angiogenin |
- Adherens junctions interactions
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- Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
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ANP32B |
acidic nuclear phosphoprotein 32 family member B |
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ANP32E |
acidic nuclear phosphoprotein 32 family member E |
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ARMCX3 |
armadillo repeat containing X-linked 3 |
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ASCC3 |
activating signal cointegrator 1 complex subunit 3 |
- ALKBH3 mediated reversal of alkylation damage
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BCAR1 |
BCAR1 scaffold protein, Cas family member |
- Downstream signal transduction
- p130Cas linkage to MAPK signaling for integrins
- VEGFA-VEGFR2 Pathway
- VEGFA-VEGFR2 Pathway
- PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
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BEX1 |
brain expressed X-linked 1 |
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BUB3 |
BUB3 mitotic checkpoint protein |
- Inactivation of APC/C via direct inhibition of the APC/C complex
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- APC/C:Cdc20 mediated degradation of mitotic proteins
- APC-Cdc20 mediated degradation of Nek2A
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- RHO GTPases Activate Formins
- Mitotic Prometaphase
- EML4 and NUDC in mitotic spindle formation
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CAV1 |
caveolin 1 |
- Triglyceride catabolism
- eNOS activation
- NOSTRIN mediated eNOS trafficking
- Basigin interactions
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- VEGFR2 mediated vascular permeability
- Extra-nuclear estrogen signaling
- FOXO-mediated transcription of cell cycle genes
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- Congenital generalized lipodystrophy (CGL)
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CCDC180 |
coiled-coil domain containing 180 |
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CCDC47 |
coiled-coil domain containing 47 |
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CCND2 |
cyclin D2 |
- Cyclin D associated events in G1
- Regulation of RUNX1 Expression and Activity
- Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
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CCT2 |
chaperonin containing TCP1 subunit 2 |
- Prefoldin mediated transfer of substrate to CCT/TriC
- Formation of tubulin folding intermediates by CCT/TriC
- Folding of actin by CCT/TriC
- Association of TriC/CCT with target proteins during biosynthesis
- Association of TriC/CCT with target proteins during biosynthesis
- BBSome-mediated cargo-targeting to cilium
- Neutrophil degranulation
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
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