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LGALS1 |
galectin 1 |
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- Post-translational protein phosphorylation
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- Mercaptoethanol
- Thiodigalactoside
- 1,4-Dithiothreitol
- Artenimol
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PTK2 |
protein tyrosine kinase 2 |
- Apoptotic cleavage of cellular proteins
- Regulation of actin dynamics for phagocytic cup formation
- Integrin signaling
- GRB2:SOS provides linkage to MAPK signaling for Integrins
- p130Cas linkage to MAPK signaling for integrins
- NCAM signaling for neurite out-growth
- NCAM signaling for neurite out-growth
- Signal regulatory protein family interactions
- EPHB-mediated forward signaling
- EPHB-mediated forward signaling
- DCC mediated attractive signaling
- DCC mediated attractive signaling
- VEGFA-VEGFR2 Pathway
- VEGFA-VEGFR2 Pathway
- RHO GTPases Activate WASPs and WAVEs
- RAF/MAP kinase cascade
- MET activates PTK2 signaling
- Extra-nuclear estrogen signaling
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
- FCGR3A-mediated phagocytosis
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- Endostatin
- 7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE
- 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE
- Fostamatinib
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RPL23A |
ribosomal protein L23a |
- L13a-mediated translational silencing of Ceruloplasmin expression
- Peptide chain elongation
- SRP-dependent cotranslational protein targeting to membrane
- SRP-dependent cotranslational protein targeting to membrane
- Viral mRNA Translation
- Selenocysteine synthesis
- Major pathway of rRNA processing in the nucleolus and cytosol
- Formation of a pool of free 40S subunits
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Termination
- Regulation of expression of SLITs and ROBOs
- Response of EIF2AK4 (GCN2) to amino acid deficiency
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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- (S)-3-phenyllactic acid
- Anisomycin
- Puromycin
- Artenimol
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TUBA1B |
tubulin alpha 1b |
- Translocation of SLC2A4 (GLUT4) to the plasma membrane
- Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
- Gap junction assembly
- MHC class II antigen presentation
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Recruitment of NuMA to mitotic centrosomes
- Formation of tubulin folding intermediates by CCT/TriC
- Post-chaperonin tubulin folding pathway
- Recycling pathway of L1
- Recycling pathway of L1
- Hedgehog 'off' state
- Cilium Assembly
- Intraflagellar transport
- RHO GTPases activate IQGAPs
- RHO GTPases Activate Formins
- COPI-mediated anterograde transport
- COPI-dependent Golgi-to-ER retrograde traffic
- COPI-independent Golgi-to-ER retrograde traffic
- Mitotic Prometaphase
- The role of GTSE1 in G2/M progression after G2 checkpoint
- Carboxyterminal post-translational modifications of tubulin
- Carboxyterminal post-translational modifications of tubulin
- HCMV Early Events
- Assembly and cell surface presentation of NMDA receptors
- Activation of AMPK downstream of NMDARs
- Aggrephagy
- Aggrephagy
- EML4 and NUDC in mitotic spindle formation
- Sealing of the nuclear envelope (NE) by ESCRT-III
- Kinesins
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- Epothilone D
- Patupilone
- CYT997
- 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
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UTRN |
utrophin |
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
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- Zinc
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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CAMK2G |
calcium/calmodulin dependent protein kinase II gamma |
- CaMK IV-mediated phosphorylation of CREB
- HSF1-dependent transactivation
- Trafficking of AMPA receptors
- Unblocking of NMDA receptors, glutamate binding and activation
- Unblocking of NMDA receptors, glutamate binding and activation
- CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
- Ras activation upon Ca2+ influx through NMDA receptor
- Phase 0 - rapid depolarisation
- Ion homeostasis
- RAF activation
- RAF/MAP kinase cascade
- Signaling by moderate kinase activity BRAF mutants
- Signaling by BRAF and RAF fusions
- Paradoxical activation of RAF signaling by kinase inactive BRAF
- Interferon gamma signaling
- Regulation of MECP2 expression and activity
- Ion transport by P-type ATPases
- Assembly and cell surface presentation of NMDA receptors
- Negative regulation of NMDA receptor-mediated neuronal transmission
- Long-term potentiation
- Signaling downstream of RAS mutants
- Signaling by RAF1 mutants
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- Bosutinib
- 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
- Fostamatinib
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CFL1 |
cofilin 1 |
- Platelet degranulation
- Regulation of actin dynamics for phagocytic cup formation
- EPHB-mediated forward signaling
- Sema3A PAK dependent Axon repulsion
- RHO GTPases Activate ROCKs
- Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
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- Dodecyldimethylamine N-oxide
- Copper
- Artenimol
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DSP |
desmoplakin |
- Apoptotic cleavage of cell adhesion proteins
- Neutrophil degranulation
- Keratinization
- Formation of the cornified envelope
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- Zinc
- Artenimol
- Zinc acetate
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- Arrhythmogenic right ventricular cardiomyopathy (ARVC)
- Naxos disease and Carvajal syndrome
- Striate palmoplantar keratoderma
- Skin fragility-woolly hair syndrome
- Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
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HSD17B10 |
hydroxysteroid 17-beta dehydrogenase 10 |
- tRNA processing in the mitochondrion
- tRNA modification in the mitochondrion
- Branched-chain amino acid catabolism
- rRNA processing in the mitochondrion
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- NADH
- 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
- Omega-3-carboxylic acids
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- 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency
- Non-syndromic X-linked mental retardation
- Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
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PHB2 |
prohibitin 2 |
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- Capsaicin
- Rocaglamide
- Didesmethylrocaglamide
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PPP2CA |
protein phosphatase 2 catalytic subunit alpha |
- Inhibition of replication initiation of damaged DNA by RB1/E2F1
- Spry regulation of FGF signaling
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Integration of energy metabolism
- PP2A-mediated dephosphorylation of key metabolic factors
- DARPP-32 events
- Degradation of beta-catenin by the destruction complex
- Beta-catenin phosphorylation cascade
- ERK/MAPK targets
- ERKs are inactivated
- MASTL Facilitates Mitotic Progression
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- Initiation of Nuclear Envelope (NE) Reformation
- CTLA4 inhibitory signaling
- Platelet sensitization by LDL
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- Signaling by GSK3beta mutants
- S33 mutants of beta-catenin aren't phosphorylated
- S37 mutants of beta-catenin aren't phosphorylated
- S45 mutants of beta-catenin aren't phosphorylated
- T41 mutants of beta-catenin aren't phosphorylated
- APC truncation mutants have impaired AXIN binding
- AXIN missense mutants destabilize the destruction complex
- Truncations of AMER1 destabilize the destruction complex
- RHO GTPases Activate Formins
- RAF activation
- Negative regulation of MAPK pathway
- Regulation of TP53 Degradation
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- Mitotic Prometaphase
- Cyclin D associated events in G1
- Cyclin A/B1/B2 associated events during G2/M transition
- Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
- EML4 and NUDC in mitotic spindle formation
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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- Vitamin E
- 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid
- (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
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RPL13A |
ribosomal protein L13a |
- L13a-mediated translational silencing of Ceruloplasmin expression
- Peptide chain elongation
- SRP-dependent cotranslational protein targeting to membrane
- SRP-dependent cotranslational protein targeting to membrane
- Viral mRNA Translation
- Selenocysteine synthesis
- Major pathway of rRNA processing in the nucleolus and cytosol
- Formation of a pool of free 40S subunits
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Termination
- Regulation of expression of SLITs and ROBOs
- Response of EIF2AK4 (GCN2) to amino acid deficiency
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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- (S)-3-phenyllactic acid
- Anisomycin
- Puromycin
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RPL23 |
ribosomal protein L23 |
- L13a-mediated translational silencing of Ceruloplasmin expression
- Peptide chain elongation
- SRP-dependent cotranslational protein targeting to membrane
- SRP-dependent cotranslational protein targeting to membrane
- Viral mRNA Translation
- Selenocysteine synthesis
- Major pathway of rRNA processing in the nucleolus and cytosol
- Formation of a pool of free 40S subunits
- GTP hydrolysis and joining of the 60S ribosomal subunit
- Eukaryotic Translation Termination
- Regulation of expression of SLITs and ROBOs
- Response of EIF2AK4 (GCN2) to amino acid deficiency
- Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
- Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
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- (S)-3-phenyllactic acid
- Anisomycin
- Puromycin
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CCT3 |
chaperonin containing TCP1 subunit 3 |
- Prefoldin mediated transfer of substrate to CCT/TriC
- Formation of tubulin folding intermediates by CCT/TriC
- Folding of actin by CCT/TriC
- Association of TriC/CCT with target proteins during biosynthesis
- Association of TriC/CCT with target proteins during biosynthesis
- BBSome-mediated cargo-targeting to cilium
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
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- Phosphoaminophosphonic Acid-Adenylate Ester
- Artenimol
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CSNK2A2 |
casein kinase 2 alpha 2 |
- Synthesis of PC
- WNT mediated activation of DVL
- Condensation of Prometaphase Chromosomes
- Signal transduction by L1
- Regulation of TP53 Activity through Phosphorylation
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
- Receptor Mediated Mitophagy
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- Regulation of PTEN stability and activity
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- [1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid
- Fostamatinib
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FASN |
fatty acid synthase |
- ChREBP activates metabolic gene expression
- Vitamin B5 (pantothenate) metabolism
- Activation of gene expression by SREBF (SREBP)
- Fatty acyl-CoA biosynthesis
- Fatty acyl-CoA biosynthesis
- NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
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GNAI1 |
G protein subunit alpha i1 |
- PLC beta mediated events
- PLC beta mediated events
- Adenylate cyclase inhibitory pathway
- Adenylate cyclase inhibitory pathway
- G-protein activation
- ADP signalling through P2Y purinoceptor 12
- Adrenaline,noradrenaline inhibits insulin secretion
- Adrenaline,noradrenaline inhibits insulin secretion
- G alpha (s) signalling events
- G alpha (i) signalling events
- G alpha (i) signalling events
- G alpha (z) signalling events
- Regulation of insulin secretion
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
- Extra-nuclear estrogen signaling
- ADORA2B mediated anti-inflammatory cytokines production
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- Guanosine-5'-Diphosphate
- Tetrafluoroaluminate Ion
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JUP |
junction plakoglobin |
- Adherens junctions interactions
- VEGFR2 mediated vascular permeability
- Neutrophil degranulation
- Keratinization
- Formation of the cornified envelope
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- Arrhythmogenic right ventricular cardiomyopathy (ARVC)
- Naxos disease and Carvajal syndrome
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MTHFD2 |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase |
- Metabolism of folate and pterines
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- Tetrahydrofolic acid
- NADH
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MYC |
MYC proto-oncogene, bHLH transcription factor |
- Transcription of E2F targets under negative control by DREAM complex
- NOTCH1 Intracellular Domain Regulates Transcription
- SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- Binding of TCF/LEF:CTNNB1 to target gene promoters
- MAPK6/MAPK4 signaling
- Ub-specific processing proteases
- Interleukin-4 and Interleukin-13 signaling
- Cyclin E associated events during G1/S transition
- Cyclin A:Cdk2-associated events at S phase entry
- TFAP2 (AP-2) family regulates transcription of cell cycle factors
- RUNX3 regulates WNT signaling
- Estrogen-dependent gene expression
- Transcriptional regulation of granulopoiesis
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- Acetylsalicylic acid
- Nadroparin
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- Choriocarcinoma
- Penile cancer
- Burkitt lymphoma
- Oral cancer
- Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
- Multiple myeloma
- Small cell lung cancer
- Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
- Osteosarcoma
- Kaposi's sarcoma
- Laryngeal cancer
- Breast cancer
- Ovarian cancer
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