ATXN1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide
GMEB2	glucocorticoid modulatory element binding protein 2
GPATCH8	G-patch domain containing 8
H2AP	H2A.P histone
H3C1	H3 clustered histone 1	Interleukin-7 signaling Interleukin-7 signaling Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Chromatin modifying enzymes SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Amyloid fiber formation Factors involved in megakaryocyte development and platelet production
HEY2	hes related family bHLH transcription factor with YRPW motif 2	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
HEYL	hes related family bHLH transcription factor with YRPW motif like	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH3 Intracellular Domain Regulates Transcription
HIVEP1	HIVEP zinc finger 1
HNRNPLL	heterogeneous nuclear ribonucleoprotein L like
HOTAIR	HOX transcript antisense RNA
HPCAL1	hippocalcin like 1
HSFX1	heat shock transcription factor family, X-linked 1
HSFY1	heat shock transcription factor Y-linked 1
HSFY2	heat shock transcription factor Y-linked 2
HSPA1A	heat shock protein family A (Hsp70) member 1A	Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase HSF1-dependent transactivation Neutrophil degranulation
IL34	interleukin 34	Other interleukin signaling
ILVBL	ilvB acetolactate synthase like
IMMT	inner membrane mitochondrial protein	Cristae formation
IPO8	importin 8	Transcriptional regulation by small RNAs
IST1	IST1 factor associated with ESCRT-III	Neutrophil degranulation Sealing of the nuclear envelope (NE) by ESCRT-III
KAT6A	lysine acetyltransferase 6A	HATs acetylate histones Regulation of TP53 Activity through Acetylation

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