ATXN1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
OTX2	orthodenticle homeobox 2		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
PANX2	pannexin 2	Electric Transmission Across Gap Junctions
PEPD	peptidase D
PHPT1	phosphohistidine phosphatase 1
PIAS1	protein inhibitor of activated STAT 1	SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins Formation of Incision Complex in GG-NER Regulation of IFNG signaling
PICALM	phosphatidylinositol binding clathrin assembly protein	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
PIM2	Pim-2 proto-oncogene, serine/threonine kinase
PLEKHB1	pleckstrin homology domain containing B1
PLEKHN1	pleckstrin homology domain containing N1
POGZ	pogo transposable element derived with ZNF domain
POM121	POM121 transmembrane nucleoporin	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation
POMP	proteasome maturation protein		Keratosis linearis with ichthyosis congenita and sclerosing keratoderma; KLICK syndrome
PPP6R2	protein phosphatase 6 regulatory subunit 2
PQBP1	polyglutamine binding protein 1	mRNA Splicing - Major Pathway	Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Non-syndromic X-linked mental retardation
PRDM1	PR/SET domain 1	Regulation of TP53 Expression
PRR20A	proline rich 20A
PRR20B	proline rich 20B
PRR20C	proline rich 20C
PRR20D	proline rich 20D
PRR20E	proline rich 20E

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