Search Results for: ATXN1

292 interactions involving ATXN1 - ataxin 1 found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
RNF4 ring finger protein 4
  • Processing of DNA double-strand break ends
  • Antigen processing: Ubiquitination & Proteasome degradation
SAR1A secretion associated Ras related GTPase 1A
SEMA4G semaphorin 4G
SETD2 SET domain containing 2, histone lysine methyltransferase
  • PKMTs methylate histone lysines
SETD6 SET domain containing 6, protein lysine methyltransferase
  • PKMTs methylate histone lysines
SGMS1 sphingomyelin synthase 1
  • Sphingolipid de novo biosynthesis
SIX5 SIX homeobox 5
  • Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
SLC25A51 solute carrier family 25 member 51
SLC4A2 solute carrier family 4 member 2
  • Bicarbonate transporters
SLC51A solute carrier family 51 subunit alpha
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2
  • RMTs methylate histone arginines
  • RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SORCS3 sortilin related VPS10 domain containing receptor 3
SOX3 SRY-box transcription factor 3
  • Deactivation of the beta-catenin transactivating complex
  • Septo-optic dysplasia
  • Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
  • 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
  • Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
SPEN spen family transcriptional repressor
SREBF2 sterol regulatory element binding transcription factor 2
  • Regulation of cholesterol biosynthesis by SREBP (SREBF)
  • Regulation of cholesterol biosynthesis by SREBP (SREBF)
  • PPARA activates gene expression
  • Activation of gene expression by SREBF (SREBP)
  • Activation of gene expression by SREBF (SREBP)
  • Transcriptional regulation of white adipocyte differentiation
  • EGR2 and SOX10-mediated initiation of Schwann cell myelination
ST6GALNAC6 ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
  • Sialic acid metabolism
  • Lewis blood group biosynthesis
STAC2 SH3 and cysteine rich domain 2
STAM2 signal transducing adaptor molecule 2
  • EGFR downregulation
  • Ub-specific processing proteases
  • Negative regulation of MET activity
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • InlB-mediated entry of Listeria monocytogenes into host cell
  • Endosomal Sorting Complex Required For Transport (ESCRT)
SUGP2 SURP and G-patch domain containing 2
SUMO1 small ubiquitin like modifier 1
  • SUMO is conjugated to E1 (UBA2:SAE1)
  • SUMO is transferred from E1 to E2 (UBE2I, UBC9)
  • SUMO is proteolytically processed
  • SUMOylation of DNA damage response and repair proteins
  • SUMO E3 ligases SUMOylate target proteins
  • SUMOylation of transcription factors
  • SUMOylation of transcription factors
  • SUMOylation of ubiquitinylation proteins
  • SUMOylation of transcription cofactors
  • SUMOylation of transcription cofactors
  • SUMOylation of SUMOylation proteins
  • SUMOylation of intracellular receptors
  • SUMOylation of intracellular receptors
  • SUMOylation of chromatin organization proteins
  • SUMOylation of chromatin organization proteins
  • SUMOylation of RNA binding proteins
  • SUMOylation of DNA replication proteins
  • SUMOylation of DNA replication proteins
  • SUMOylation of DNA methylation proteins
  • SUMOylation of DNA methylation proteins
  • SUMOylation of immune response proteins
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Nonhomologous End-Joining (NHEJ)
  • Processing of DNA double-strand break ends
  • Formation of Incision Complex in GG-NER
  • G2/M DNA damage checkpoint
  • Regulation of IFNG signaling
  • Negative regulation of activity of TFAP2 (AP-2) family transcription factors
  • Negative regulation of activity of TFAP2 (AP-2) family transcription factors
  • Postmitotic nuclear pore complex (NPC) reformation
  • Maturation of nucleoprotein
  • Maturation of nucleoprotein

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