PTTG1 and UBE4A

Data Source:
BioGRID (enzymatic study)

		PTTG1	UBE4A
Description		PTTG1 regulator of sister chromatid separation, securin	ubiquitination factor E4A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding	Protein Binding Ubiquitin-ubiquitin Ligase Activity
	Biological Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Negative Regulation Of Endopeptidase Activity Anaphase-promoting Complex-dependent Catabolic Process Homologous Chromosome Segregation Chromosome Organization Cell Division Negative Regulation Of Mitotic Sister Chromatid Separation	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent ERAD Pathway
Pathways		APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Dermatomyositis or juvenile dermatomyositis ( 26362759) Insulin-related traits ( 22791750) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 21408207 28714469 19838195) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)	Celiac disease and Rheumatoid arthritis ( 26546613) Fat distribution (HIV) ( 21897333)
Interacting Genes		23 interacting genes: ANAPC11 ANAPC2 AURKA CAMK2A CDC20 CDC27 CDC34 CDK1 CRK CUL1 DNAJA1 FZR1 PLCG2 PPP2R2D PPP2R5A PRKN PTTG1IP RPS10 TP53 UBE2C UBE2N UBE4A XRCC6	13 interacting genes: CASP6 EPHA2 GZMB IP6K1 MAVS PTTG1 RSAD2 SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP
Entrez ID		9232	9354
HPRD ID		04998	06793
Ensembl ID		ENSG00000164611	ENSG00000110344
Uniprot IDs		O95997 Q6IAL9	Q14139
PDB IDs			1WGM
Enriched GO Terms of Interacting Partners?
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